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- Pharmacology For Amoxycillin + Ambroxol
Amoxycillin + Ambroxol Pharmacology
Amoxycillin + Ambroxol
About Amoxycillin + AmbroxolN/AMechanism of Action of Amoxycillin + AmbroxolN/APharmacokinets of Amoxycillin + AmbroxolN/AOnset of Action for Amoxycillin + AmbroxolN/ADuration of Action for Amoxycillin + AmbroxolN/AHalf Life of Amoxycillin + AmbroxolN/ASide Effects of Amoxycillin + AmbroxolN/AContra-indications of Amoxycillin + AmbroxolN/ASpecial Precautions while taking Amoxycillin + AmbroxolN/APregnancy Related InformationContraindicated; Ambroxol is contraindicated in pregnancy so the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; Ambroxol is contraindicated in pregnancy so the combination generic cannot be used in lactation.Children Related InformationN/AIndications for Amoxycillin + AmbroxolIt is a combination of the beta lactam antibiotic Amoxycillin and a mucolytic Ambroxol.
1.Respiratory tract infection
2.Bronchitis
3.Asthmatic bronchitis
4.Bronchiectasis
5.Bronchial asthma
6.Pharyngitis
7.Pneumonia
8.Tonsillitis.
Interactions for Amoxycillin + AmbroxolN/ATypical Dosage for Amoxycillin + AmbroxolAdult:
Mild infection: 1 tablet to be taken 3 times daily
Children below 10 years: ? tablet to be taken 3 times daily.
Above 5 years: 5 ml to be taken 3 times daily
Below 5 years: 2.5 ml to be taken 3 times daily
Schedule of Amoxycillin + AmbroxolN/AStorage Requirements for Amoxycillin + AmbroxolN/AEffects of Missed Dosage of Amoxycillin + AmbroxolN/AEffects of Overdose of Amoxycillin + AmbroxolN/AAmoxycillin
About AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
Ambroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Amoxycillin + Ambroxol in Your City
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Amoxycillin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for amoxycillin + ambroxol might be better known than amoxycillin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amoxycillin + ambroxol in stock, you can ask for one of the branded alternatives for amoxycillin + ambroxol.