Trastuzumab Pharmacology

Trastuzumab

About Trastuzumab

Humanized IgGl kappa monoclonal antibody,Anticancer.

Mechanism of Action of Trastuzumab

The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Trastuzumab has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2.Trastuzumab is a mediator of antibody-dependent cellular cytotoxicity (ADCC). In vitro, Trastuzumab mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.

Pharmacokinets of Trastuzumab

Distribution: Vd: 44 mL/kg; unlikely to cross intact blood brain barrier.
Metabolism: Metabolism Most likely removed by opsonization via the reticuloendothelial system.

Onset of Action for Trastuzumab

N/A

Duration of Action for Trastuzumab

N/A

Half Life of Trastuzumab

Average 28.5 days

Side Effects of Trastuzumab

1.Chills
2.Fever
3.Headache
4.Dizziness
5.Back pain
6.Arthralgia
7.Increased cough
8.Infection
9.Insomnia
10.Oedema
11.Tachycardia
12.Diarrhea
13.Paresthesia
14.Rashes.

Contra-indications of Trastuzumab

N/A

Special Precautions while taking Trastuzumab

1.Preexisting cardiac dysfunction and pulmonary disease (e.g. asthma, COPD), prior cardiotoxic therapy, extensive tumour involvement of lungs.
2.Monitor cardiac function frequently and watch for signs of cardiotoxicity (ventricular dysfunction or CHF).

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated, not begin brest feeding for six months after discontinuing the drug

Children Related Information

Not recommended

Indications for Trastuzumab

For treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2.

Interactions for Trastuzumab

1.Increased risk of severe cardiotoxicity with anthracyclines.
2.Increased risk of leukopenia and anaemia in combination chemotherapy (e.g. paclitaxel).
3.Paclitaxel may decrease the clearance of trastuzumab.
4.Increased risk of bleeding with warfarin.

Typical Dosage for Trastuzumab

Trastuzumab usually is administered intravenously with an initial dose of 4 mg per kilogram of body weight followed by a weekly dose of 2 mg per kilogram of body weight.

Schedule of Trastuzumab

N/A

Storage Requirements for Trastuzumab

Trastuzumab should be stored at 2-8?C (36-46?F) and should not be frozen.

Effects of Missed Dosage of Trastuzumab

N/A

Effects of Overdose of Trastuzumab

N/A

Home Delivery for Trastuzumab in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trastuzumab.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trastuzumab and other medicines and health products. Home delivery services for trastuzumab may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trastuzumab only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trastuzumab before they complete the sale. You can get this information while placing the order for trastuzumab with the pharmacy.

Trastuzumab is a generic medicine name and there are several brands available for it. Some of the brands for trastuzumab might be better known than trastuzumab itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trastuzumab in stock, you can ask for one of the branded alternatives for trastuzumab.