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- Pharmacology For Halobetasol Propionate + Fusidic Acid
Halobetasol Propionate + Fusidic Acid Pharmacology
Halobetasol Propionate + Fusidic Acid
About Halobetasol Propionate + Fusidic AcidN/AMechanism of Action of Halobetasol Propionate + Fusidic AcidN/APharmacokinets of Halobetasol Propionate + Fusidic AcidN/AOnset of Action for Halobetasol Propionate + Fusidic AcidN/ADuration of Action for Halobetasol Propionate + Fusidic AcidN/AHalf Life of Halobetasol Propionate + Fusidic AcidN/ASide Effects of Halobetasol Propionate + Fusidic AcidN/AContra-indications of Halobetasol Propionate + Fusidic AcidN/ASpecial Precautions while taking Halobetasol Propionate + Fusidic AcidN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Halobetasol Propionate + Fusidic AcidTreatment of skin condition such as infected dermatoses.Interactions for Halobetasol Propionate + Fusidic AcidN/ATypical Dosage for Halobetasol Propionate + Fusidic AcidN/ASchedule of Halobetasol Propionate + Fusidic AcidN/AStorage Requirements for Halobetasol Propionate + Fusidic AcidN/AEffects of Missed Dosage of Halobetasol Propionate + Fusidic AcidN/AEffects of Overdose of Halobetasol Propionate + Fusidic AcidN/AHalobetasol propionate
About Halobetasol propionateTopical primarily synthetic Corticosteroid, Antiinflammatory and antipruritic.Mechanism of Action of Halobetasol propionateHalobetasol propionate is a synthetic corticosteroid for topical dermatological use. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Halobetasol propionateAbsorption: It is absorbed after topical application.Onset of Action for Halobetasol propionateN/ADuration of Action for Halobetasol propionateN/AHalf Life of Halobetasol propionateN/ASide Effects of Halobetasol propionate1.Burning
2.Stinging
3.Itching
4.Redness
5.Blistering
6.Peeling
Contra-indications of Halobetasol propionate1.Hypersensitivity to Halobetasol propionate
2.Occlusive dressings
Special Precautions while taking Halobetasol propionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Halobetasol propionate1.Eczema
2.Psoriasis
3.Dermatitis
4. Rashes
5.Insect bites
6.Poison ivy
7.Inflammation of the skin
Interactions for Halobetasol propionateN/ATypical Dosage for Halobetasol propionateApply to the affected area 2 - 4 times a day. Halobetasol should not be used for longer than 2 weeksSchedule of Halobetasol propionateN/AStorage Requirements for Halobetasol propionateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Halobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Halobetasol propionateProvide symptomatic treatment and supportive measures.Fusidic acid
About Fusidic acidA bacteriostatic Steroid Antibiotic, Systemic antibacterial, anti-infective.Mechanism of Action of Fusidic acidFusidic acid is a bactericidal or bacteriostatic drug depending upon the concentration. It inhibits the transfer of aminoacid from aminoacyl sRNA to the protein. This will leads to inhibition of protein synthesis in the bacteria and prevent the growth of microbes.Pharmacokinets of Fusidic acidAbsorption: It is very poorly absorbed after topical administration.Onset of Action for Fusidic acidNULL.Duration of Action for Fusidic acidNULL.Half Life of Fusidic acidN/ASide Effects of Fusidic acid1. Contact dermatitis
2. Irritation
3. Burning
4. Redness
5. Swelling
6. Rashes
Contra-indications of Fusidic acid1. Hypersensitivity to Fusidic acidSpecial Precautions while taking Fusidic acid1. Avoid contact with eyes
2. If irritation occurs discard the use of medicament
3. Hepatic impairment
4. Monitor liver function test
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Fusidic acidPrimary and secondary skin infections
1. Impetigo
2. Erythrasma
3. Folliculitis
4. Sycosis barbae
5. Hidradenitis
Interactions for Fusidic acidNULL.Typical Dosage for Fusidic acidFusidic acid 2% cream or ointment .Clean and dry the affected area. Apply the drug as thin layer.2 - 4 times daily. Schedule of Fusidic acidN/AStorage Requirements for Fusidic acidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Fusidic acidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fusidic acidGive supportive measures and symptomatic treatment.Home Delivery for Halobetasol Propionate + Fusidic Acid in Your City
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Please be aware that you should take halobetasol propionate + fusidic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for halobetasol propionate + fusidic acid before they complete the sale. You can get this information while placing the order for halobetasol propionate + fusidic acid with the pharmacy.
Halobetasol Propionate + Fusidic Acid is a generic medicine name and there are several brands available for it. Some of the brands for halobetasol propionate + fusidic acid might be better known than halobetasol propionate + fusidic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have halobetasol propionate + fusidic acid in stock, you can ask for one of the branded alternatives for halobetasol propionate + fusidic acid.