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- Pharmacology For Halobetasol Propionate + Miconazole
Halobetasol Propionate + Miconazole Pharmacology
Halobetasol Propionate + Miconazole
About Halobetasol Propionate + MiconazoleN/AMechanism of Action of Halobetasol Propionate + MiconazoleN/APharmacokinets of Halobetasol Propionate + MiconazoleN/AOnset of Action for Halobetasol Propionate + MiconazoleN/ADuration of Action for Halobetasol Propionate + MiconazoleN/AHalf Life of Halobetasol Propionate + MiconazoleN/ASide Effects of Halobetasol Propionate + MiconazoleN/AContra-indications of Halobetasol Propionate + MiconazoleN/ASpecial Precautions while taking Halobetasol Propionate + MiconazoleN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Halobetasol Propionate + MiconazoleCorticosteroid responsive dermatoses where secondary fungal infection is present.Interactions for Halobetasol Propionate + MiconazoleN/ATypical Dosage for Halobetasol Propionate + MiconazoleN/ASchedule of Halobetasol Propionate + MiconazoleN/AStorage Requirements for Halobetasol Propionate + MiconazoleN/AEffects of Missed Dosage of Halobetasol Propionate + MiconazoleN/AEffects of Overdose of Halobetasol Propionate + MiconazoleN/AHalobetasol propionate
About Halobetasol propionateTopical primarily synthetic Corticosteroid, Antiinflammatory and antipruritic.Mechanism of Action of Halobetasol propionateHalobetasol propionate is a synthetic corticosteroid for topical dermatological use. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Halobetasol propionateAbsorption: It is absorbed after topical application.Onset of Action for Halobetasol propionateN/ADuration of Action for Halobetasol propionateN/AHalf Life of Halobetasol propionateN/ASide Effects of Halobetasol propionate1.Burning
2.Stinging
3.Itching
4.Redness
5.Blistering
6.Peeling
Contra-indications of Halobetasol propionate1.Hypersensitivity to Halobetasol propionate
2.Occlusive dressings
Special Precautions while taking Halobetasol propionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Halobetasol propionate1.Eczema
2.Psoriasis
3.Dermatitis
4. Rashes
5.Insect bites
6.Poison ivy
7.Inflammation of the skin
Interactions for Halobetasol propionateN/ATypical Dosage for Halobetasol propionateApply to the affected area 2 - 4 times a day. Halobetasol should not be used for longer than 2 weeksSchedule of Halobetasol propionateN/AStorage Requirements for Halobetasol propionateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Halobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Halobetasol propionateProvide symptomatic treatment and supportive measures.Miconazole
About MiconazoleAn imidazole derivative, Broad spectrum Antifungal.Mechanism of Action of MiconazoleMiconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesisPharmacokinets of MiconazoleAbsorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.Onset of Action for MiconazoleN/ADuration of Action for MiconazoleN/AHalf Life of Miconazole1 daySide Effects of Miconazole1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis Contra-indications of Miconazole1.Hypersensitivity to Miconazole and other Azole antifungalsSpecial Precautions while taking Miconazole1.Hepatic dysfunctionPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Miconazole1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitisInteractions for MiconazoleBenzoyl peroxide: Antibacterial synergism. Typical Dosage for MiconazoleAdult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days
CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part
Schedule of MiconazoleHStorage Requirements for MiconazoleThe drug should be stored at 15 - 30 degree C.Effects of Missed Dosage of MiconazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MiconazoleGive supportive measures and treatment.
Home Delivery for Halobetasol Propionate + Miconazole in Your City
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Halobetasol Propionate + Miconazole is a generic medicine name and there are several brands available for it. Some of the brands for halobetasol propionate + miconazole might be better known than halobetasol propionate + miconazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have halobetasol propionate + miconazole in stock, you can ask for one of the branded alternatives for halobetasol propionate + miconazole.