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- Pharmacology For Mecobalamin + Ginkgo Biloba
Mecobalamin + Ginkgo Biloba Pharmacology
Mecobalamin + Ginkgo Biloba
About Mecobalamin + Ginkgo BilobaN/AMechanism of Action of Mecobalamin + Ginkgo BilobaN/APharmacokinets of Mecobalamin + Ginkgo BilobaN/AOnset of Action for Mecobalamin + Ginkgo BilobaN/ADuration of Action for Mecobalamin + Ginkgo BilobaN/AHalf Life of Mecobalamin + Ginkgo BilobaN/ASide Effects of Mecobalamin + Ginkgo BilobaN/AContra-indications of Mecobalamin + Ginkgo BilobaN/ASpecial Precautions while taking Mecobalamin + Ginkgo BilobaN/APregnancy Related InformationNot recommendedOld Age Related InformationMay be usedBreast Feeding Related InformationUse only when cleaely neededChildren Related InformationNot recommendedIndications for Mecobalamin + Ginkgo Biloba1.To improve the blood circulation in the brain - in cases of impaired mental function, "dementia" and Alzheimer's disease.
2.In cases in neurogenic depression, intensity, neurosis, migraine, neuralgia.
3.To improve the mental capacity for work and sexual potency.
4.To support the immune system and for prophylactic of aging of tissues and arteriosclerosis
Interactions for Mecobalamin + Ginkgo BilobaN/ATypical Dosage for Mecobalamin + Ginkgo BilobaN/ASchedule of Mecobalamin + Ginkgo BilobaN/AStorage Requirements for Mecobalamin + Ginkgo BilobaN/AEffects of Missed Dosage of Mecobalamin + Ginkgo BilobaN/AEffects of Overdose of Mecobalamin + Ginkgo BilobaN/AMecobalamin
About MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/AGinkgo Biloba
About Ginkgo BilobaN/AMechanism of Action of Ginkgo BilobaThe mechanism of action of ginkgo is believed to be produced by its functions as a neuroprotective agent, an antioxidant, a free-radical scavenger, a membrane stabilizer, and an inhibitor of platelet-activating factor via the terpene ginkgolide B.Other pharmacologic effects include the following: endothelium relaxation mediated by inhibition of 3',5'-cyclic GMP (guanosine monophosphate) phosphodiesterase; inhibition of age-related loss of muscarinergic cholinoceptors and ?-adrenoceptors; and stimulation of choline uptake in the hippocampus.Ginkgo extract also has been shown to inhibit beta-amyloid deposition.Pharmacokinets of Ginkgo BilobaN/AOnset of Action for Ginkgo BilobaN/ADuration of Action for Ginkgo BilobaN/AHalf Life of Ginkgo BilobaN/ASide Effects of Ginkgo Biloba1.Headaches
2.Dizziness
3.Palpitations
4.GI disturbances
5.Bleeding disorders
6.Skin hypersensitivity reactions
Contra-indications of Ginkgo Biloba1.Hyper sensitivity
2.Warfarin ,aspirin, antiplatelet agents, herbal medications such as feverfew, garlic, ginseng, dong quai, red clover, and other natural coumarins.
Special Precautions while taking Ginkgo Biloba1.Patients receiving anticoagulants or drugs that may affect platelet aggregation.
2.The presence of amentoflavone in Gingko biloba leaves would indicate a potential for interactions with many medications through the strong inhibition of CYP3A4 and CYP2C9.
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ginkgo Biloba1.Dementia
2.Cerebrovascular and peripheral activator
Interactions for Ginkgo BilobaN/ATypical Dosage for Ginkgo Biloba120 to 240 mg per day, in 2 to 3 doses.Schedule of Ginkgo BilobaN/AStorage Requirements for Ginkgo BilobaN/AEffects of Missed Dosage of Ginkgo BilobaN/AEffects of Overdose of Ginkgo BilobaN/AHome Delivery for Mecobalamin + Ginkgo Biloba in Your City
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