Lanthanum Carbonate Pharmacology

Lanthanum Carbonate

About Lanthanum Carbonate

N/A

Mechanism of Action of Lanthanum Carbonate

Fosrenol is a carbonate salt of the rare-earth metal lanthanum. This salt dissociates in the acid of the stomach to release lanthanum ions that bind dietary phosphate released from food during digestion. Binding phosphate ions forms highly insoluble lanthanum-phosphate complexes, which are not absorbed in the rest of the GI tract. Dietary phosphate thus cannot contribute to serum phosphate levels, allowing the kidneys to reduce these levels to normal reanges. Lower serum phosphate levels also reduce the prodution of calcium phosphate, high levels of which can lead to ectopic calcification.

Pharmacokinets of Lanthanum Carbonate

Absorption: Bioavailability < 0.002%
Distribution: Highly bound to plasma proteins.
Metabolism: Not metabolised.
Excretion: Eliminated mainly by the biliary system.

Onset of Action for Lanthanum Carbonate

N/A

Duration of Action for Lanthanum Carbonate

N/A

Half Life of Lanthanum Carbonate

36 hr.

Side Effects of Lanthanum Carbonate

1.Nausea
2.Vomiting
3.Dialysis Graft Occlusion
4.Diarrhea
5.Headache
6.Abdominal Pain
7.Hypotension
8.Constipation

Contra-indications of Lanthanum Carbonate

N/A

Special Precautions while taking Lanthanum Carbonate

1.Caution when used in patients with acute peptic ulcer, ulcerative colitis, Crohn's disease or bowel obstruction.
2.Tablets should be thoroughly chewed before swallowing.

Pregnancy Related Information

Not recommended

Old Age Related Information

May be used

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
Paediatric:Not recommended

Indications for Lanthanum Carbonate

Hyperphosphataemia in end stage renal failure

Interactions for Lanthanum Carbonate

1.Compounds that are known to interact with antacids should not be taken within 2 hr of administering lanthanum carbonate.
2.Absorption of Ciprofloxacin,levothyroxine,fat soluble vitamins are reduced

Typical Dosage for Lanthanum Carbonate

Adult: Initially, 0.75-2.25 g daily, given in divided doses with meals. Dose may be adjusted every 2-3 wk until an acceptable serum phosphate concentration is achieved; usual maintenance dose: 1.5-3 g daily in divided doses. Max: 3.75 g daily.
Should be taken with food. (Take w/ or immediately after meals. Chew thoroughly before swallowing. Do not swallow whole.)

Schedule of Lanthanum Carbonate

N/A

Storage Requirements for Lanthanum Carbonate

Store at 25?C (77?F): excursions permitted to 15-30?C (59-86?F). Protect from moisture.

Effects of Missed Dosage of Lanthanum Carbonate

N/A

Effects of Overdose of Lanthanum Carbonate

The symptoms associated with overdose are adverse reactions such as headache, nausea and vomiting. In clinical trials in healthy adults, GI symptoms were reported with daily doses up to 6000 mg/day of lanthanum carbonate administered with food. Given the topical activity of lanthanum in the gut, and the excretion in feces of the majority of the dose, supportive therapy is recommended for overdosage.

Home Delivery for Lanthanum Carbonate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lanthanum carbonate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lanthanum carbonate and other medicines and health products. Home delivery services for lanthanum carbonate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lanthanum carbonate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lanthanum carbonate before they complete the sale. You can get this information while placing the order for lanthanum carbonate with the pharmacy.

Lanthanum Carbonate is a generic medicine name and there are several brands available for it. Some of the brands for lanthanum carbonate might be better known than lanthanum carbonate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lanthanum carbonate in stock, you can ask for one of the branded alternatives for lanthanum carbonate.