Trypsin + Bromelain + Rutin Pharmacology

Trypsin + Bromelain + Rutin

About Trypsin + Bromelain + Rutin
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Mechanism of Action of Trypsin + Bromelain + Rutin
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Pharmacokinets of Trypsin + Bromelain + Rutin
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Onset of Action for Trypsin + Bromelain + Rutin
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Duration of Action for Trypsin + Bromelain + Rutin
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Half Life of Trypsin + Bromelain + Rutin
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Side Effects of Trypsin + Bromelain + Rutin
1.Harmless alteration in the consistency, color and odor of stool
2.A sensation of fullness, flatulence, and occasional episodes of nausea are possible during high- dosage administration. They can be avoided by administration of the enzyme preparation in divided doses during a day.
3.Allergic reaction occurs rarely and disappears after the discontinuation of the drug.
Contra-indications of Trypsin + Bromelain + Rutin
The preparation must not be used by patients with severe inborn or gained coagulation disorders. (E.g- hemophilia, severe liver damage, dialyzed patients).
Special Precautions while taking Trypsin + Bromelain + Rutin
N/A
Pregnancy Related Information
Not recommended
Old Age Related Information
May be used
Breast Feeding Related Information
Not recommended
Children Related Information
Use with caution
Indications for Trypsin + Bromelain + Rutin
1.Inflammatory episodes of rheumatic and degenerative conditions, such as Rheumatoid Arthritis, osteoarthritis, Spondylopathies, Tendonitis and Bursitis.
2.Treatment of edema and inflammation of traumatic origin such as contusions, lacerations and cuts.
3.Treatment of edema and inflammation following surgery, tooth extraction, cellulitis, abscess, sport injuries and sprains.
Interactions for Trypsin + Bromelain + Rutin
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Typical Dosage for Trypsin + Bromelain + Rutin
Adult:2 tablets three times a day, are recommended for adult patients.
Children: (6 years and above) 1 tablet/ 10kg body weight/ day up to maximum 6 tablets a day. Total recommended dose is administered in 2-3 divided doses.
Schedule of Trypsin + Bromelain + Rutin
N/A
Storage Requirements for Trypsin + Bromelain + Rutin
Store in a cool and dry place away from direct sunlight.
Effects of Missed Dosage of Trypsin + Bromelain + Rutin
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Effects of Overdose of Trypsin + Bromelain + Rutin
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About
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Bromelain

About Bromelain
Bromelain is a mixture of several protein-digesting enzymes (known as proteases) along with other types of enzymes, enzyme inhibitors and calcium.Bromelain is an enzyme found in pineapple juice and in the pineapple stem.
Mechanism of Action of Bromelain
Bromelain, increases blood fibrinolytic activity as well as inhibiting fibrinogen synthesis; bromelain also directly degrades fibrin and fibrinogen. Kininogen and bradykinin serum and tissue levels are lowered by bromelain and it also affects prostaglandin synthesis, which gives it's anti-inflammatory effects.Bromelain has been found to reduce the excretion of proinflammatory cytokines as well as chemokines in a study into its possible mechanism of action in ulcerative colitis, inflammatory bowel disease, Crohn's disease.
Pharmacokinets of Bromelain
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Onset of Action for Bromelain
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Duration of Action for Bromelain
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Half Life of Bromelain
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Side Effects of Bromelain
1.Diarrhea
2.Stomach and intestinal discomfort
3.May cause allergic reactions
Contra-indications of Bromelain
N/A
Special Precautions while taking Bromelain
1.Allergies: Allergic to pineapple, wheat, celery, papain, carrot, fennel, cypress pollen, or grass pollen, might have an allergic reaction to bromelain.
2.Surgery: Bromelain might increase the risk of bleeding during and after surgery. Stop using bromelain at least 2 weeks before a scheduled surgery.
Pregnancy Related Information
Not recommended
Old Age Related Information
May be used
Breast Feeding Related Information
Not recommended
Children Related Information
May be used
Indications for Bromelain
1.Arthritis (osteoarthritis) pain and knee function when used in combination with trypsin and rutin.
2.Cancer (prevention and treatment)
3.Cardiac and circulatory disorders
4.Diarrhea
5.Inflammatory Bowel Disease
6.Multiple Sclerosis
7.Musculoskeletal injuries
8.Improving antibiotic absorption
9.Swelling (edema)
Interactions for Bromelain
1.Amoxicillin:Taking bromelain might increase how much amoxicillin is in the body. Taking bromelain along with amoxicillin might increase the effects and side effects of amoxicillin.
2.Tetracycline antibiotics:Taking bromelain might increase how much antibiotic the body absorbs. Taking bromelain along with some antibiotics called tetracyclines might increase effects and side effects of these antibiotics.
3.Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs):Bromelain might slow blood clotting. Taking bromelain along with medications that also slow clotting might increase the chances of bruising and bleeding.

Typical Dosage for Bromelain
For osteoarthritis: a combination product,which contains rutin 100 mg, trypsin 48 mg, and bromelain 90 mg, given as 2 tablets 3 times daily has been used.


Schedule of Bromelain
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Storage Requirements for Bromelain
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Effects of Missed Dosage of Bromelain
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Effects of Overdose of Bromelain
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Rutin

About Rutin
Glycoside between the flavonol quercetin and the disaccharide rutinose. Rutin may have antioxidant, anti-inflammatory, anticarcinogenic, antithrombotic,cytoprotective and vasoprotective activities.
Mechanism of Action of Rutin
1.Rutin inhibits platelet aggregation, as well as decreasing capillary permeability, making the blood thinner and improving circulation.
2.Rutin shows anti-inflammatory activity in some animal and in vitro models.
3.Rutin inhibits aldose reductase activit. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol.
4.Rutin also strengthens the capillaries, and, therefore, can reduce the symptoms of haemophilia. It also may help to prevent a common, unpleasant-looking, venous edema of the legs; however, a double-blind clinical study on the effect of buckwheat tea containing rutin did not show a significant effect above placebo.
5.Rutin, as ferulic acid, can reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease.
6.There is also some evidence that rutin can be used to treat hemorrhoids, varicosis, and microangiopathy.
7.Rutin is also an antioxidant.
Pharmacokinets of Rutin
Absorption:Only about 17% of an ingested dose is absorbed
Metabolism:Hepatic
Onset of Action for Rutin
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Duration of Action for Rutin
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Half Life of Rutin
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Side Effects of Rutin
1.Headache
2.Flushing
3.Rashes
4.Stomach upset
Contra-indications of Rutin
Rutin is contraindicated in those who are hypersensitive to any component of a rutincontaining product.

Special Precautions while taking Rutin
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Pregnancy Related Information
Avoid use
Old Age Related Information
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Breast Feeding Related Information
Avoid use
Children Related Information
N/A
Indications for Rutin
1.Combination,with trypsin, and bromelain for treatment of pain in osteoarhritis
2.Management of venous edema
3.To decrease capillary fragility
4.Cancer prevention
Interactions for Rutin
N/A
Typical Dosage for Rutin
For osteoarthritis: 2 tablets of a combination,which contains 100 mg of rutin, 48 mg of trypsin, and 90 mg of bromelain, 3 times daily.

Schedule of Rutin
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Storage Requirements for Rutin
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Effects of Missed Dosage of Rutin
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Effects of Overdose of Rutin
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