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- Pharmacology For Mecobalamin + Pregabalin
Mecobalamin + Pregabalin Pharmacology
Mecobalamin + Pregabalin
About Mecobalamin + PregabalinN/AMechanism of Action of Mecobalamin + PregabalinN/APharmacokinets of Mecobalamin + PregabalinN/AOnset of Action for Mecobalamin + PregabalinN/ADuration of Action for Mecobalamin + PregabalinN/AHalf Life of Mecobalamin + PregabalinN/ASide Effects of Mecobalamin + PregabalinN/AContra-indications of Mecobalamin + PregabalinN/ASpecial Precautions while taking Mecobalamin + PregabalinN/APregnancy Related InformationContra indicatedOld Age Related InformationDosage adjustment may be neededBreast Feeding Related InformationContra indicatedChildren Related InformationNot recommendedIndications for Mecobalamin + PregabalinPostherpetic neuralgia.Interactions for Mecobalamin + PregabalinN/ATypical Dosage for Mecobalamin + PregabalinN/ASchedule of Mecobalamin + PregabalinN/AStorage Requirements for Mecobalamin + PregabalinN/AEffects of Missed Dosage of Mecobalamin + PregabalinN/AEffects of Overdose of Mecobalamin + PregabalinN/AMecobalamin
About MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/APregabalin
About PregabalinA GABA agonist, Anticonvulsant.Mechanism of Action of PregabalinPregabalin is a GABA neurotransmitter analog. It produces its action by modulating calcium channels and also reduces the release of neurotransmitters such as Glutamate, Norepinephrine, Serotonin, Dopamine and Substance P.Pharmacokinets of PregabalinAbsorption: Pregabalin is rapidly absorbed after oral doses.Pregabalin is not bound to plasma proteins and undergoes negligible metabolism.Excretion: It is excreted mainly in urine.Onset of Action for PregabalinN/ADuration of Action for PregabalinN/AHalf Life of Pregabalin6-7 hoursSide Effects of Pregabalin1.Dizziness
2.Somnolence
3.Blurred vision
4.Diplopia
5.Increased appetite
6.Weight gain
7.Dry mouth
8.Constipation
9.Vomiting
10.Flatulence
11.Euphoria
12.Confusion
13.Reduced libido
14.Erectile dysfunction
15.Irritability
16.Vertigo
17.Ataxia
18.Tremor
19.Dysarthria
20.Paraesthesia
21.Fatigue
22.Oedema
23.Disturbances of attention, memory, coordination, and gait also occur frequently
Contra-indications of Pregabalin1.Hypersensitivity to PregabalinSpecial Precautions while taking Pregabalin1.Renal impairment
2.Driving vehicles, operating machines and people involving any other dangerous activities
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Pregabalin1.Epilepsy
2.Generalised anxiety disorder
3.Neuropathic pain
Interactions for PregabalinN/ATypical Dosage for Pregabalin150- 300mg / day in 2 divided dosesSchedule of PregabalinN/AStorage Requirements for PregabalinStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of PregabalinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the doseEffects of Overdose of PregabalinGive supportive measures and symptomatic treatment.Home Delivery for Mecobalamin + Pregabalin in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mecobalamin + pregabalin and other medicines and health products. Home delivery services for mecobalamin + pregabalin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take mecobalamin + pregabalin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mecobalamin + pregabalin before they complete the sale. You can get this information while placing the order for mecobalamin + pregabalin with the pharmacy.
Mecobalamin + Pregabalin is a generic medicine name and there are several brands available for it. Some of the brands for mecobalamin + pregabalin might be better known than mecobalamin + pregabalin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mecobalamin + pregabalin in stock, you can ask for one of the branded alternatives for mecobalamin + pregabalin.