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- Pharmacology For Diclofenac Sodium + Linseed oil + Methyl Salicylate + Menthol
Diclofenac Sodium + Linseed oil + Methyl Salicylate + Menthol Pharmacology
Diclofenac Sodium + Linseed oil + Methyl Salicylate + Menthol
About Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AMechanism of Action of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholDiclofenac relieves pain & inflammation
Methyl Salicylate provides counter-irritant action
Menthol enhances Diclofenac absorption and provides cooling action
Linseed oil helps in reducing inflammation
Pharmacokinets of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AOnset of Action for Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ADuration of Action for Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AHalf Life of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ASide Effects of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AContra-indications of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ASpecial Precautions while taking Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Sodium + Linseed oil + Methyl Salicylate + Menthol1.Back pain
2.Knee pain
3.Sprain & strains
4.Soft tissue disorders
5.Osteoarthritis Knee
6.Spondylosis
7.Cervical spondylosis
8.Injury
9.Arthritis
10.Shoulder lesions
11.Frozen Shoulder
12.Prolapsed intervertebral disc
13.Thumb, knee, shoulder stiffness
14.Rheumatoid arthritis
15.Tennis elbow
Interactions for Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ATypical Dosage for Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ASchedule of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AStorage Requirements for Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AEffects of Missed Dosage of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/AEffects of Overdose of Diclofenac Sodium + Linseed oil + Methyl Salicylate + MentholN/ADiclofenac Sodium
About Diclofenac SodiumN/AMechanism of Action of Diclofenac SodiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .Pharmacokinets of Diclofenac SodiumAbsorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac Sodium1- 4.5 hoursDuration of Action for Diclofenac SodiumHoursHalf Life of Diclofenac Sodium2 hoursSide Effects of Diclofenac Sodium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13. Rash
Contra-indications of Diclofenac Sodium1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Sodium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Sodium1.Ankylosing spondylitis
2.Acute gout
3.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
4.Osteoarthritis
5.For the relief of pain and inflammation in dental minor surgery and orthopedic
6.Dysmenorrhoea
7.Juvenile chronic arthritis
8.Migraine
Interactions for Diclofenac SodiumLithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
Methotrexate : Toxicity enhanced.
Salicylates : Efficacy of salicylates reduced.
Cyclosporine : Increases nephrotoxicity of both agents.
Hydantoins : Increases serum levels resulting in toxicity.
Typical Dosage for Diclofenac SodiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
Maximum dose: 3 mg / kg body weight / day in divided doses
Schedule of Diclofenac SodiumHStorage Requirements for Diclofenac SodiumStore Diclofenac sodium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac SodiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac SodiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Linseed Oil
About Linseed OilIt contains powerful, rare natural antioxidants (lignans), omega-3 fatty acids, vitamins and minerals. It is a popular oil in cosmetic manufacturing and to a lesser degree (but no less suitable), massage therapists and aroma therapists. Linseed oil is also well absorbed by the skin.Mechanism of Action of Linseed OilN/APharmacokinets of Linseed OilN/AOnset of Action for Linseed OilN/ADuration of Action for Linseed OilN/AHalf Life of Linseed OilN/ASide Effects of Linseed OilN/AContra-indications of Linseed OilN/ASpecial Precautions while taking Linseed OilTaking blood thinners may not be safe to use along with flaxseed oil as treatment for a medical condition. Flaxseed will make your blood thinning medication more effective, which could be dangerous.
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Linseed Oil1.Lower Cholesterol:Flaxseed oil and other sources of omega-3 fatty acids may increase your level of HDL--what is commonly called "good" cholesterol--and can help lower LDL ("bad" cholesterol) levels.
2.Healthy Heart:One of the elements in flaxseed oil, called alpha-linolenic acid (ALA), can lower your risk of heart disease through a number of factors. ALA keeps your blood vessels healthy, keeps platelets from sticking together and may even prevent minor arrhythmias.
3.Reduce Inflammation:The omega-3 found in flaxseed oil is a naturally-occurring anti-inflammatory agent. People who have arthritis, lupus, psoriasis and inflammatory bowel disorders may find a reduction in inflammation by adding flaxseed oil to their diets.
Interactions for Linseed OilN/ATypical Dosage for Linseed OilAdults can safely take up to 2 tbsp. of flaxseed oil or two soft-gels daily for medical use. Check with your doctor before giving your child flaxseed oil.Schedule of Linseed OilN/AStorage Requirements for Linseed OilN/AEffects of Missed Dosage of Linseed OilN/AEffects of Overdose of Linseed OilN/AMethyl salicylate
About Methyl salicylateSalicylates, Rubefacient, counterirritant.Mechanism of Action of Methyl salicylateMethyl salicylate is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.Pharmacokinets of Methyl salicylateN/AOnset of Action for Methyl salicylateN/ADuration of Action for Methyl salicylateN/AHalf Life of Methyl salicylateN/ASide Effects of Methyl salicylateN/AContra-indications of Methyl salicylateN/ASpecial Precautions while taking Methyl salicylateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl salicylateN/AInteractions for Methyl salicylateN/ATypical Dosage for Methyl salicylateN/ASchedule of Methyl salicylateN/AStorage Requirements for Methyl salicylateN/AEffects of Missed Dosage of Methyl salicylateN/AEffects of Overdose of Methyl salicylateN/AMenthol
About MentholTerpenes and terpenoid, Antipruritic, decongestant, topical analgesic.Mechanism of Action of MentholMenthol acts as a local anesthetic on the respiratory passageways and causing cough suppression. When Menthol is rubbed on the skin, it acts as a rubefacient and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and mild local anaesthetic effect relieves itching. It has good soothing effect and acts as a demulcent. It also acts as a carminative.Pharmacokinets of MentholN/AOnset of Action for MentholN/ADuration of Action for MentholN/AHalf Life of MentholN/ASide Effects of Menthol1.Irritation
2.Anxiety
3.Excitement
4.Delirium
5.Colic
6.Nausea
7.Vomiting
8.Diarrhoea
9.Convulsions
10.Apnoea
11.Asystole
12.Contact dermatitis
13.Allergic reactions
Contra-indications of Menthol1. Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Menthol1.Should not apply Menthol directly in to or near the nostrils of small children or asthma patients
2.Prolonged use
3.Seizures
4.Should not take steam inhalation orally
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution
Children Related InformationUse with caution
below 2 years: ContraindicatedIndications for Menthol1. Rubefacient.
2.Ingredient in cough preparations
3.Antipruritic
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5.Sore throat
6.Cold sores
7.Hay fever
8.As an inhalant to relieve nasal, bronchial, or upper respiratory congestion
9.Sinusitis
10.Bronchial cough
11.Pharyngeal inflammation
Interactions for MentholN/ATypical Dosage for MentholDosage individualized based on requirements of the patient.
Lozenges: Dissolve lozenge (5%-10% menthol) slowly in the mouth hourly as needed by the patients.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Menthol (3.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1tsp of solution for each pint, up to thrice daily
Schedule of MentholN/AStorage Requirements for MentholStore at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.Effects of Missed Dosage of MentholTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MentholProvide symptomatic treatment and supportive measures.Home Delivery for Diclofenac Sodium + Linseed oil + Methyl Salicylate + Menthol in Your City
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