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- Pharmacology For Clobetasol Propionate + Fusidic Acid
Clobetasol Propionate + Fusidic Acid Pharmacology
Clobetasol Propionate + Fusidic Acid
About Clobetasol Propionate + Fusidic AcidN/AMechanism of Action of Clobetasol Propionate + Fusidic AcidN/APharmacokinets of Clobetasol Propionate + Fusidic AcidN/AOnset of Action for Clobetasol Propionate + Fusidic AcidN/ADuration of Action for Clobetasol Propionate + Fusidic AcidN/AHalf Life of Clobetasol Propionate + Fusidic AcidN/ASide Effects of Clobetasol Propionate + Fusidic AcidN/AContra-indications of Clobetasol Propionate + Fusidic AcidN/ASpecial Precautions while taking Clobetasol Propionate + Fusidic AcidN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Clobetasol Propionate + Fusidic AcidSkin infection and associated inflammations.Interactions for Clobetasol Propionate + Fusidic AcidN/ATypical Dosage for Clobetasol Propionate + Fusidic AcidN/ASchedule of Clobetasol Propionate + Fusidic AcidN/AStorage Requirements for Clobetasol Propionate + Fusidic AcidN/AEffects of Missed Dosage of Clobetasol Propionate + Fusidic AcidN/AEffects of Overdose of Clobetasol Propionate + Fusidic AcidN/AClobetasol propionate
About Clobetasol propionateTopical adenocorticoid, Anti inflammatory.Mechanism of Action of Clobetasol propionateClobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.Pharmacokinets of Clobetasol propionateAbsorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)Onset of Action for Clobetasol propionateN/ADuration of Action for Clobetasol propionateN/AHalf Life of Clobetasol propionateN/ASide Effects of Clobetasol propionate1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
Contra-indications of Clobetasol propionate1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasol propionate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below12 years: ContraindicatedIndications for Clobetasol propionate1.Skin disorders
2.Eczema
3.Psoriasis
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionateN/ATypical Dosage for Clobetasol propionateTopical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week. Schedule of Clobetasol propionateHStorage Requirements for Clobetasol propionateStore at room temperature. Protect from heat, moisture and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasol propionateGive supportive measures and symptomatic treatment.Fusidic acid
About Fusidic acidA bacteriostatic Steroid Antibiotic, Systemic antibacterial, anti-infective.Mechanism of Action of Fusidic acidFusidic acid is a bactericidal or bacteriostatic drug depending upon the concentration. It inhibits the transfer of aminoacid from aminoacyl sRNA to the protein. This will leads to inhibition of protein synthesis in the bacteria and prevent the growth of microbes.Pharmacokinets of Fusidic acidAbsorption: It is very poorly absorbed after topical administration.Onset of Action for Fusidic acidNULL.Duration of Action for Fusidic acidNULL.Half Life of Fusidic acidN/ASide Effects of Fusidic acid1. Contact dermatitis
2. Irritation
3. Burning
4. Redness
5. Swelling
6. Rashes
Contra-indications of Fusidic acid1. Hypersensitivity to Fusidic acidSpecial Precautions while taking Fusidic acid1. Avoid contact with eyes
2. If irritation occurs discard the use of medicament
3. Hepatic impairment
4. Monitor liver function test
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Fusidic acidPrimary and secondary skin infections
1. Impetigo
2. Erythrasma
3. Folliculitis
4. Sycosis barbae
5. Hidradenitis
Interactions for Fusidic acidNULL.Typical Dosage for Fusidic acidFusidic acid 2% cream or ointment .Clean and dry the affected area. Apply the drug as thin layer.2 - 4 times daily. Schedule of Fusidic acidN/AStorage Requirements for Fusidic acidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Fusidic acidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fusidic acidGive supportive measures and symptomatic treatment.Home Delivery for Clobetasol Propionate + Fusidic Acid in Your City
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Please be aware that you should take clobetasol propionate + fusidic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clobetasol propionate + fusidic acid before they complete the sale. You can get this information while placing the order for clobetasol propionate + fusidic acid with the pharmacy.
Clobetasol Propionate + Fusidic Acid is a generic medicine name and there are several brands available for it. Some of the brands for clobetasol propionate + fusidic acid might be better known than clobetasol propionate + fusidic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobetasol propionate + fusidic acid in stock, you can ask for one of the branded alternatives for clobetasol propionate + fusidic acid.