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- Pharmacology For Dexrabeprazole + Domperidone
Dexrabeprazole + Domperidone Pharmacology
Dexrabeprazole + Domperidone
About Dexrabeprazole + DomperidoneN/AMechanism of Action of Dexrabeprazole + DomperidoneRabeprazole inhibits the H+-K+-ATPase enzyme and thereby decreases gastric acid secretion.
Domperidone increases lower esophageal sphincter tone and enhances upper GI motility, thereby preventing reflux of gastric contents into esophagus.
Pharmacokinets of Dexrabeprazole + DomperidoneN/AOnset of Action for Dexrabeprazole + DomperidoneN/ADuration of Action for Dexrabeprazole + DomperidoneN/AHalf Life of Dexrabeprazole + DomperidoneN/ASide Effects of Dexrabeprazole + Domperidone1.Headache
2.Abdominal pain
3.Diarrhea, flatulence
4.Constipation
5.Dry mouth
6.Dizziness
7.Rash
8.Peripheral edema
Contra-indications of Dexrabeprazole + Domperidone1.Patients with known hypersensitivity to rabeprazole, domperidone, or substituted benzimidazoles or to any excipient used in the formulation.
2.Hepatic and/or renal impairment, prolactin-releasing pituitary tumour (prolactinoma).
Special Precautions while taking Dexrabeprazole + DomperidoneN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNot recommended for use in children under 16 years of age.Indications for Dexrabeprazole + DomperidoneGastroesophageal reflux disease (GERD) not responding to rabeprazole alone.Interactions for Dexrabeprazole + DomperidoneN/ATypical Dosage for Dexrabeprazole + DomperidoneCapsule(Rabeprazole sodium lP 20 mg+ Domperidone BP 30 mg) is to be taken once daily for 4 to 8 weeks, before breakfast in the morning.Schedule of Dexrabeprazole + DomperidoneN/AStorage Requirements for Dexrabeprazole + DomperidoneN/AEffects of Missed Dosage of Dexrabeprazole + DomperidoneN/AEffects of Overdose of Dexrabeprazole + DomperidoneN/ADexrabeprazole
About DexrabeprazoleDexrabeprazole is the R+-isomer of racemate rabeprazole that is more effective than the recemate and s-rabeprazole.Mechanism of Action of DexrabeprazoleRabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.Pharmacokinets of Dexrabeprazole1.Absorption: Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.
2.Distribution: Protein-binding: 97%.
3.Metabolism: Extensively metabolised in the liver by cytochrome P450 isoenzymes.
4.Excretion: Metabolites are mainly excreted in the urine (90%).
Onset of Action for Dexrabeprazole1 hr.Duration of Action for Dexrabeprazole24 hr.Half Life of DexrabeprazoleAbout 1 hr.Side Effects of Dexrabeprazole1.Nausea
2.Headache
3.Diarrhoea nausea
4.Rhinitis
5.Abdominal pain
6.Asthenia
7.Flatulence
8.Pharyngitis
9.Nausea&vomiting
10.Non-specific pain-back pain
11.Dizziness
12.Flu syndrome
13.Infection
14.Cough
15.Constipation
16.Insomnia
Contra-indications of DexrabeprazoleN/ASpecial Precautions while taking Dexrabeprazole1.Caution required in administration to patient with severe hepatic dysfunction.
2.Gastric or oesophageal malignancy should be excluded.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related Information >12yrs use with caution
NEONATES>>Contraindicated
Indications for Dexrabeprazole1.Gastroesophageal reflux disease (GERD)
2.Gastric and duodenal ulcer
3.Acid peptic disease
Interactions for Dexrabeprazole1.Dexrabeprazole Sodium can interact with blood thinners.
2.It produce a intensive increase in drugs whose absorption is pH dependent (e.g digoxin, ketoconazole)
Typical Dosage for DexrabeprazoleAdults- 10 mg once daily for 4-8 weeks depending upon condition and response. Maintenance ? 5 -10 mg once daily.Schedule of DexrabeprazoleHStorage Requirements for DexrabeprazoleStore it at room temperature.Effects of Missed Dosage of DexrabeprazoleTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.Effects of Overdose of DexrabeprazoleSeek emergency medical attention.Domperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Home Delivery for Dexrabeprazole + Domperidone in Your City
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Dexrabeprazole + Domperidone is a generic medicine name and there are several brands available for it. Some of the brands for dexrabeprazole + domperidone might be better known than dexrabeprazole + domperidone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexrabeprazole + domperidone in stock, you can ask for one of the branded alternatives for dexrabeprazole + domperidone.