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- Pharmacology For Tolterodine Tartarate + Tamsulosin
Tolterodine Tartarate + Tamsulosin Pharmacology
Tolterodine Tartarate + Tamsulosin
About Tolterodine Tartarate + TamsulosinN/AMechanism of Action of Tolterodine Tartarate + TamsulosinN/APharmacokinets of Tolterodine Tartarate + TamsulosinN/AOnset of Action for Tolterodine Tartarate + TamsulosinN/ADuration of Action for Tolterodine Tartarate + TamsulosinN/AHalf Life of Tolterodine Tartarate + TamsulosinN/ASide Effects of Tolterodine Tartarate + TamsulosinN/AContra-indications of Tolterodine Tartarate + TamsulosinN/ASpecial Precautions while taking Tolterodine Tartarate + TamsulosinN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContra indicatedIndications for Tolterodine Tartarate + TamsulosinBladder outlet obstruction with concomitant overactive bladderInteractions for Tolterodine Tartarate + TamsulosinN/ATypical Dosage for Tolterodine Tartarate + TamsulosinOnce-a-day combination of Tolterodine tartarate extended release 4mg and Tamsulosin hydrochloride extended release 0.4mg dosage capsules.
Schedule of Tolterodine Tartarate + TamsulosinN/AStorage Requirements for Tolterodine Tartarate + TamsulosinN/AEffects of Missed Dosage of Tolterodine Tartarate + TamsulosinN/AEffects of Overdose of Tolterodine Tartarate + TamsulosinN/ATolterodine Tartarate
About Tolterodine TartarateAnticholinergic ( antimuscarinic), Treat urinary incontinence.Mechanism of Action of Tolterodine TartarateTolterodine tartrate is a specific muscarinic receptor (M3 receptor) antagonist. It blocks muscarinic receptors which can be found on the muscle cells of the bladder wall. It prevents the action of acetyl choline on these receptors. Acetylcholine acting on these receptors causes the muscle in the bladder wall to contract, and the bladder to empty. By preventing this, Tolterodine helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. This in turn reduces the need to pass urine.
Stimulation of muscarinic receptors causes the bladder to contract and empty. Tolterodine relax the involuntary muscle in the wall of the bladder.
Pharmacokinets of Tolterodine TartarateAbsorption: It is well absorbed after oral administration.
Distribution: Tolterodine tartrate is widely distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver by oxidation to active 5-hydroxy methyl metabolite.
Excretion: it is excreted mainly in the urine and the rest excreted through faeces.
Onset of Action for Tolterodine TartarateN/ADuration of Action for Tolterodine TartarateN/AHalf Life of Tolterodine Tartarate2 - 3.5 hoursSide Effects of Tolterodine Tartarate1. Headache
2. Abdominal pain
3. Constipation
4. Blurred vision
5. Urinary retention
6. Dry mouth
7. Flatulence
8. Vomiting
9. Drowsiness
10. Confusion
11. Dyspepsia
12. Paresthesia
13. Dryness of the skin and eyes
14. Somnolence
15. Nervousness
16. Dysuria
Contra-indications of Tolterodine Tartarate1. Hypersensitivity to Tolterodine
2. Urinary retention
3. Gastric retention
4. Ulcerative colitis
5. Crohn`s disease
6. Abnormal muscle weakness
7. Closed angle glaucoma
Special Precautions while taking Tolterodine Tartarate1. Hepatic impairment
2. Renal impairment
3. Heart failure
4. Bradycardia
5. Ischaemic heart disease
6. Autonomic neuropathy
7. Arrhythmia
8. Intestinal obstruction
9. Hiatus hernia
10. Hypokalaemia
10. Do not drive vehicle, operate machine and other works which require mental alertness
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: Contraindicated
Indications for Tolterodine Tartarate1. Urinary frequency
2. Urinary urgency
3. Urinary incontinence
Interactions for Tolterodine TartaratePatients receiving cytochrome P450 3A4 inhibitors (erythromycin, ketoconazole, miconazole, etc.) should not receive more than 1mg twice daily.
Typical Dosage for Tolterodine TartarateOral
Adult: Initial dose: 4 mg / day in 2 divided doses based on response and tolerance dose can be reduced to 2 mg / day.
Children: not recommended
Schedule of Tolterodine TartarateN/AStorage Requirements for Tolterodine TartarateStore in a cool dark place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of Tolterodine TartarateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Tolterodine TartarateGive supportive measures and symptomatic treatment.Tamsulosin
About TamsulosinSelective Alpha1a Adrenergic Antagonist , For benign prostatic hyperplasia.Mechanism of Action of TamsulosinTamsulosin is adrenergic alpha receptor antagonist. It inhibits alpha 1A and alpha 1D subtype receptors. Tamsulosin selectively inhibits alpha 1A receptor in the prostate and leads to relaxation of smooth muscles in the bladder neck and prostate. This will improve urine flow and reduces BPH symptoms.
Adrenergic nerves releases adrenalin which produces contraction of muscles. Tamsulosin is selectively inhibit alpha 1A receptor in the prostate and bladder neck and relaxes the muscles and decrease the obstruction to the flow of urine in prostate hypertrophy.
Pharmacokinets of TamsulosinAbsorption: It is well absorbed after oral administration under fasting condition.
Distribution: It is distributed widely to tissues in protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: The drug and its metabolites are excreted primarily in the urine and about 21% is excreted through faeces.
Onset of Action for TamsulosinN/ADuration of Action for Tamsulosin9 - 15 hoursHalf Life of Tamsulosin5- 10 hoursSide Effects of Tamsulosin1. Dizziness
2. Headache
3. Abnormal ejaculation
4. Vertigo
5. Postural hypotension
6. Somnolence
7. Insomnia
8. Diarrhoea
9. Nausea
10. Back pain
11. Syncope
12. Infection
13. Rhinitis
14. Sinusitis
15. Pharyngitis
16. Rash
17. Pruritis
18. Urticaria
Contra-indications of Tamsulosin1. Hypersensitivity to TamsulosinSpecial Precautions while taking Tamsulosin1. During initiation of therapy slowly get up from chair or bed.
2. Avoid conditions in which injury could occur as a result of syncope.
3. Driving vehicle, operating machine and other hazardous woks.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Tamsulosin1. Benign Prostatic hyperplasia (BPH)
Interactions for TamsulosinCimetidine: Results in significant decrease in clearance of tamsulosin AUC.
Alpha adrenergic blocking agents: Tamsulosin should not be used in combination with other alpha adrenergics.
Typical Dosage for TamsulosinAdult: 400mg / day drug to be taken 30 minutes after the same meal each day and if sufficient response does not obtained then increase the dose to 800mg / day after 2 or 4 weeks.
Children: Not recommended
Schedule of TamsulosinN/AStorage Requirements for TamsulosinStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of TamsulosinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. If treatment with Tamsulosin is missed for several days, contact doctor before restarting the medication and a lower dose may be necessary to restart the drug.Effects of Overdose of TamsulosinGive supportive measures and symptomatic treatment. Administer IV fluids and if needed give vasopressors. Monitor renal functions.Home Delivery for Tolterodine Tartarate + Tamsulosin in Your City
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Tolterodine Tartarate + Tamsulosin is a generic medicine name and there are several brands available for it. Some of the brands for tolterodine tartarate + tamsulosin might be better known than tolterodine tartarate + tamsulosin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolterodine tartarate + tamsulosin in stock, you can ask for one of the branded alternatives for tolterodine tartarate + tamsulosin.