Tolterodine Tartarate + Tamsulosin Pharmacology

Tolterodine Tartarate + Tamsulosin

About Tolterodine Tartarate + Tamsulosin
N/A
Mechanism of Action of Tolterodine Tartarate + Tamsulosin
N/A
Pharmacokinets of Tolterodine Tartarate + Tamsulosin
N/A
Onset of Action for Tolterodine Tartarate + Tamsulosin
N/A
Duration of Action for Tolterodine Tartarate + Tamsulosin
N/A
Half Life of Tolterodine Tartarate + Tamsulosin
N/A
Side Effects of Tolterodine Tartarate + Tamsulosin
N/A
Contra-indications of Tolterodine Tartarate + Tamsulosin
N/A
Special Precautions while taking Tolterodine Tartarate + Tamsulosin
N/A
Pregnancy Related Information
Contra indicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contra indicated
Indications for Tolterodine Tartarate + Tamsulosin
Bladder outlet obstruction with concomitant overactive bladder
Interactions for Tolterodine Tartarate + Tamsulosin
N/A
Typical Dosage for Tolterodine Tartarate + Tamsulosin
Once-a-day combination of Tolterodine tartarate extended release 4mg and Tamsulosin hydrochloride extended release 0.4mg dosage capsules.


Schedule of Tolterodine Tartarate + Tamsulosin
N/A
Storage Requirements for Tolterodine Tartarate + Tamsulosin
N/A
Effects of Missed Dosage of Tolterodine Tartarate + Tamsulosin
N/A
Effects of Overdose of Tolterodine Tartarate + Tamsulosin
N/A

Tolterodine Tartarate

About Tolterodine Tartarate
Anticholinergic ( antimuscarinic), Treat urinary incontinence.
Mechanism of Action of Tolterodine Tartarate
Tolterodine tartrate is a specific muscarinic receptor (M3 receptor) antagonist. It blocks muscarinic receptors which can be found on the muscle cells of the bladder wall. It prevents the action of acetyl choline on these receptors. Acetylcholine acting on these receptors causes the muscle in the bladder wall to contract, and the bladder to empty. By preventing this, Tolterodine helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. This in turn reduces the need to pass urine.
Stimulation of muscarinic receptors causes the bladder to contract and empty. Tolterodine relax the involuntary muscle in the wall of the bladder.
Pharmacokinets of Tolterodine Tartarate
Absorption: It is well absorbed after oral administration.
Distribution: Tolterodine tartrate is widely distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver by oxidation to active 5-hydroxy methyl metabolite.
Excretion: it is excreted mainly in the urine and the rest excreted through faeces.
Onset of Action for Tolterodine Tartarate
N/A
Duration of Action for Tolterodine Tartarate
N/A
Half Life of Tolterodine Tartarate
2 - 3.5 hours
Side Effects of Tolterodine Tartarate
1. Headache
2. Abdominal pain
3. Constipation
4. Blurred vision
5. Urinary retention
6. Dry mouth
7. Flatulence
8. Vomiting
9. Drowsiness
10. Confusion
11. Dyspepsia
12. Paresthesia
13. Dryness of the skin and eyes
14. Somnolence
15. Nervousness
16. Dysuria

Contra-indications of Tolterodine Tartarate
1. Hypersensitivity to Tolterodine
2. Urinary retention
3. Gastric retention
4. Ulcerative colitis
5. Crohn`s disease
6. Abnormal muscle weakness
7. Closed angle glaucoma
Special Precautions while taking Tolterodine Tartarate
1. Hepatic impairment
2. Renal impairment
3. Heart failure
4. Bradycardia
5. Ischaemic heart disease
6. Autonomic neuropathy
7. Arrhythmia
8. Intestinal obstruction
9. Hiatus hernia
10. Hypokalaemia
10. Do not drive vehicle, operate machine and other works which require mental alertness

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Tolterodine Tartarate
1. Urinary frequency
2. Urinary urgency
3. Urinary incontinence
Interactions for Tolterodine Tartarate
Patients receiving cytochrome P450 3A4 inhibitors (erythromycin, ketoconazole, miconazole, etc.) should not receive more than 1mg twice daily.
Typical Dosage for Tolterodine Tartarate
Oral
Adult: Initial dose: 4 mg / day in 2 divided doses based on response and tolerance dose can be reduced to 2 mg / day.
Children: not recommended
Schedule of Tolterodine Tartarate
N/A
Storage Requirements for Tolterodine Tartarate
Store in a cool dark place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Tolterodine Tartarate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolterodine Tartarate
Give supportive measures and symptomatic treatment.

Tamsulosin

About Tamsulosin
Selective Alpha1a Adrenergic Antagonist , For benign prostatic hyperplasia.
Mechanism of Action of Tamsulosin
Tamsulosin is adrenergic alpha receptor antagonist. It inhibits alpha 1A and alpha 1D subtype receptors. Tamsulosin selectively inhibits alpha 1A receptor in the prostate and leads to relaxation of smooth muscles in the bladder neck and prostate. This will improve urine flow and reduces BPH symptoms.
Adrenergic nerves releases adrenalin which produces contraction of muscles. Tamsulosin is selectively inhibit alpha 1A receptor in the prostate and bladder neck and relaxes the muscles and decrease the obstruction to the flow of urine in prostate hypertrophy.
Pharmacokinets of Tamsulosin
Absorption: It is well absorbed after oral administration under fasting condition.
Distribution: It is distributed widely to tissues in protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: The drug and its metabolites are excreted primarily in the urine and about 21% is excreted through faeces.
Onset of Action for Tamsulosin
N/A
Duration of Action for Tamsulosin
9 - 15 hours
Half Life of Tamsulosin
5- 10 hours
Side Effects of Tamsulosin
1. Dizziness
2. Headache
3. Abnormal ejaculation
4. Vertigo
5. Postural hypotension
6. Somnolence
7. Insomnia
8. Diarrhoea
9. Nausea
10. Back pain
11. Syncope
12. Infection
13. Rhinitis
14. Sinusitis
15. Pharyngitis
16. Rash
17. Pruritis
18. Urticaria

Contra-indications of Tamsulosin
1. Hypersensitivity to Tamsulosin
Special Precautions while taking Tamsulosin
1. During initiation of therapy slowly get up from chair or bed.
2. Avoid conditions in which injury could occur as a result of syncope.
3. Driving vehicle, operating machine and other hazardous woks.

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Tamsulosin
1. Benign Prostatic hyperplasia (BPH)


Interactions for Tamsulosin
Cimetidine: Results in significant decrease in clearance of tamsulosin AUC.
Alpha adrenergic blocking agents: Tamsulosin should not be used in combination with other alpha adrenergics.
Typical Dosage for Tamsulosin
Adult: 400mg / day drug to be taken 30 minutes after the same meal each day and if sufficient response does not obtained then increase the dose to 800mg / day after 2 or 4 weeks.
Children: Not recommended
Schedule of Tamsulosin
N/A
Storage Requirements for Tamsulosin
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Tamsulosin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. If treatment with Tamsulosin is missed for several days, contact doctor before restarting the medication and a lower dose may be necessary to restart the drug.
Effects of Overdose of Tamsulosin
Give supportive measures and symptomatic treatment. Administer IV fluids and if needed give vasopressors. Monitor renal functions.

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