Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum Pharmacology

Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum

About Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Mechanism of Action of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Pharmacokinets of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Onset of Action for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Duration of Action for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Half Life of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Side Effects of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Contra-indications of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Special Precautions while taking Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
Do not use in broken skin.
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
Contra indicated
Indications for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
1.Sport Injuries
2.Tennis Elbow
3.Lumbago
4.Sprain & Strain
5.Arthritis Pain
6.Ankylosing Spondylitis
Interactions for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Typical Dosage for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Schedule of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Storage Requirements for Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Effects of Missed Dosage of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Effects of Overdose of Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum
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Diclofenac Sodium

About Diclofenac Sodium
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Mechanism of Action of Diclofenac Sodium
Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .
Pharmacokinets of Diclofenac Sodium
Absorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
Onset of Action for Diclofenac Sodium
1- 4.5 hours
Duration of Action for Diclofenac Sodium
Hours
Half Life of Diclofenac Sodium
2 hours
Side Effects of Diclofenac Sodium
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13. Rash
Contra-indications of Diclofenac Sodium
1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Sodium
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 14: contraindicated
Indications for Diclofenac Sodium
1.Ankylosing spondylitis
2.Acute gout
3.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
4.Osteoarthritis
5.For the relief of pain and inflammation in dental minor surgery and orthopedic
6.Dysmenorrhoea
7.Juvenile chronic arthritis
8.Migraine
Interactions for Diclofenac Sodium
Lithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
Methotrexate : Toxicity enhanced.
Salicylates : Efficacy of salicylates reduced.
Cyclosporine : Increases nephrotoxicity of both agents.
Hydantoins : Increases serum levels resulting in toxicity.
Typical Dosage for Diclofenac Sodium
Adult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
Maximum dose: 3 mg / kg body weight / day in divided doses
Schedule of Diclofenac Sodium
H
Storage Requirements for Diclofenac Sodium
Store Diclofenac sodium at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Diclofenac Sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Diclofenac Sodium
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Menthol

About Menthol
Terpenes and terpenoid, Antipruritic, decongestant, topical analgesic.
Mechanism of Action of Menthol
Menthol acts as a local anesthetic on the respiratory passageways and causing cough suppression. When Menthol is rubbed on the skin, it acts as a rubefacient and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and mild local anaesthetic effect relieves itching. It has good soothing effect and acts as a demulcent. It also acts as a carminative.
Pharmacokinets of Menthol
N/A
Onset of Action for Menthol
N/A
Duration of Action for Menthol
N/A
Half Life of Menthol
N/A
Side Effects of Menthol
1.Irritation
2.Anxiety
3.Excitement
4.Delirium
5.Colic
6.Nausea
7.Vomiting
8.Diarrhoea
9.Convulsions
10.Apnoea
11.Asystole
12.Contact dermatitis
13.Allergic reactions
Contra-indications of Menthol
1. Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Menthol
1.Should not apply Menthol directly in to or near the nostrils of small children or asthma patients
2.Prolonged use
3.Seizures
4.Should not take steam inhalation orally
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
below 2 years: Contraindicated
Indications for Menthol
1. Rubefacient.
2.Ingredient in cough preparations
3.Antipruritic
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5.Sore throat
6.Cold sores
7.Hay fever
8.As an inhalant to relieve nasal, bronchial, or upper respiratory congestion
9.Sinusitis
10.Bronchial cough
11.Pharyngeal inflammation
Interactions for Menthol
N/A
Typical Dosage for Menthol
Dosage individualized based on requirements of the patient.
Lozenges: Dissolve lozenge (5%-10% menthol) slowly in the mouth hourly as needed by the patients.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Menthol (3.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1tsp of solution for each pint, up to thrice daily
Schedule of Menthol
N/A
Storage Requirements for Menthol
Store at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.
Effects of Missed Dosage of Menthol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Menthol
Provide symptomatic treatment and supportive measures.

Methyl salicylate

About Methyl salicylate
Salicylates, Rubefacient, counterirritant.
Mechanism of Action of Methyl salicylate
Methyl salicylate is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.
Pharmacokinets of Methyl salicylate
N/A
Onset of Action for Methyl salicylate
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Duration of Action for Methyl salicylate
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Half Life of Methyl salicylate
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Side Effects of Methyl salicylate
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Contra-indications of Methyl salicylate
N/A
Special Precautions while taking Methyl salicylate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Methyl salicylate
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Interactions for Methyl salicylate
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Typical Dosage for Methyl salicylate
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Schedule of Methyl salicylate
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Storage Requirements for Methyl salicylate
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Effects of Missed Dosage of Methyl salicylate
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Effects of Overdose of Methyl salicylate
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Camphor

About Camphor
N/A
Mechanism of Action of Camphor
Camphor acts as a rubefacient when it is rubbed on the skin and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and a mild local anaesthetic effect and relieves itching. When ingested in small amounts, it creates feelings of warmth and comfort in the epigastrium. Camphor acts as a local anesthetic on the respiratory passageways and causing cough suppression.
Pharmacokinets of Camphor
Absorption: Well absorbed through the skin, Distribution: Widely distributed in the body and crosses the placenta, Metabolism: Metabolized in liver, Excretion: Excreted mainly through urine and a minor portion is excreted through lungs.
Onset of Action for Camphor
N/A
Duration of Action for Camphor
N/A
Half Life of Camphor
N/A
Side Effects of Camphor
1.Gastric irritation
2.Anxiety
3.Excitement
4.Delirium
5.Colic
6.Nausea
7.Vomiting
8.Diarrhoea
9.Convulsions
10.Apnoea
11.Asystole
Contra-indications of Camphor
1.Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Camphor
1.Should not apply camphor directly in to or near the nostrils of small children or asthma patients
2.Prolonged use may lead to accumulation in adipose tissue
3.Seizures.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Children (below 2 years): Contraindicated
Indications for Camphor
1.Rubefacient
2.Ingredient in cough preparations
3.Antipruritic
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5. As balm for chapped lips, cold sores
6.As an inhalant to relieve nasal, bronchial or upper respiratory congestion.
Interactions for Camphor
N/A
Typical Dosage for Camphor
Dosage individualized based on requirement and condition of the patient.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Camphor (6.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1 tsp of solution for each pint, up to thrice daily.
Schedule of Camphor
N/A
Storage Requirements for Camphor
Store at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.
Effects of Missed Dosage of Camphor
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Camphor
Provide symptomatic treatment and supportive measures.
Ingestion: If camphor has been ingested recently, and the condition of the patient allows, perform gastric lavage. If only small amounts have been ingested, administer cathartics.
Inhalation: If camphor has been inhaled, remove patient from exposure, administer fresh air or oxygen, and establish respiration.
Topical: If there has been external contact with camphor, wash skin thoroughly with soap and water. Irrigate eyes with plenty of water.
In severe poisoning: Assist respiration in respiratory depression. Perform artificial respiration if required. Treat convulsions with diazepam or other suitable drugs. Protect the airway by endotracheal intubation or suitable measures, Perform gastric lavage and reduce absorption by administration of activated charcoal, and then a saline cathartic if required. Resin and charcoal haemoperfusion may be used in severe cases.

Capsicum

About Capsicum
N/A
Mechanism of Action of Capsicum
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Pharmacokinets of Capsicum
N/A
Onset of Action for Capsicum
N/A
Duration of Action for Capsicum
N/A
Half Life of Capsicum
N/A
Side Effects of Capsicum
1.Reddening or burning sensation of the skin may occur
2.Rare, allergic reactions to capsicum may occur

Contra-indications of Capsicum
Allergic to peppers (green, red, orange, yellow, chili, peppercorns, etc.) and to capsicum.
Special Precautions while taking Capsicum
1.Do not apply to injured skin.
2.Do not apply heat to the affected area after using this product.
3.Do not get capsicum in the eyes. Severe burning, stinging, and eye irritation may occur. If capsicum gets in the eyes, seek medical attention.
4.To avoid damage to skin and nerves, do not use this product for longer than 2 days. Wait 14 days before reapplying the product to the same location
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended
Indications for Capsicum
Capsicum has been used for muscle or joint pain.
Interactions for Capsicum
N/A
Typical Dosage for Capsicum
N/A
Schedule of Capsicum
N/A
Storage Requirements for Capsicum
N/A
Effects of Missed Dosage of Capsicum
N/A
Effects of Overdose of Capsicum
Seek emergency medical attention if an overdose is suspected.

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Diclofenac Sodium +Menthol + Methyl Salicylate + Camphor +Capsicum is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac sodium +menthol + methyl salicylate + camphor +capsicum might be better known than diclofenac sodium +menthol + methyl salicylate + camphor +capsicum itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac sodium +menthol + methyl salicylate + camphor +capsicum in stock, you can ask for one of the branded alternatives for diclofenac sodium +menthol + methyl salicylate + camphor +capsicum.