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- Pharmacology For Rosuvastatin + Fenofibrate
Rosuvastatin + Fenofibrate Pharmacology
Rosuvastatin + Fenofibrate
About Rosuvastatin + FenofibrateN/AMechanism of Action of Rosuvastatin + FenofibrateN/APharmacokinets of Rosuvastatin + FenofibrateN/AOnset of Action for Rosuvastatin + FenofibrateN/ADuration of Action for Rosuvastatin + FenofibrateN/AHalf Life of Rosuvastatin + FenofibrateN/ASide Effects of Rosuvastatin + FenofibrateN/AContra-indications of Rosuvastatin + FenofibrateN/ASpecial Precautions while taking Rosuvastatin + FenofibrateN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra indicatedChildren Related InformationContra indicatedIndications for Rosuvastatin + FenofibrateHyperlipidaemias.Interactions for Rosuvastatin + FenofibrateN/ATypical Dosage for Rosuvastatin + FenofibrateN/ASchedule of Rosuvastatin + FenofibrateN/AStorage Requirements for Rosuvastatin + FenofibrateN/AEffects of Missed Dosage of Rosuvastatin + FenofibrateN/AEffects of Overdose of Rosuvastatin + FenofibrateN/ARosuvastatin
About RosuvastatinStatin, HMG-CoA Reductase Inhibitor, Antilipemic.Mechanism of Action of RosuvastatinIt is a hypolipidaemic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels.Pharmacokinets of RosuvastatinAbsorption: Readily absorbed orally, and bioavailability is about 20%. Distribution: Widely distributed in a protein bound form, Metabolism: Not significantly metabolized in liver, only about 10% is metabolized in liver. Excretion: Excreted mainly through bile.Onset of Action for RosuvastatinN/ADuration of Action for RosuvastatinN/AHalf Life of Rosuvastatin20 hoursSide Effects of Rosuvastatin1.Headache
2.Dizziness
3.Insomnia
4.Asthenia
5.Abdominal discomfort
6.Heart burn
7.Abdominal pain
8.Nausea
9.Dyspepsia
10.Flatulence
11.Constipation
12.Abnormal liver function tests
13.Rash
14.Fatigue
15.Myositis
16.Chest pain
17.Myopathy
18.Upper respiratory tract infections
Contra-indications of Rosuvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
4.Severe renal impairment
Special Precautions while taking Rosuvastatin1.Monitor hepatic and renal function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and Myopathy
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated below 9 years of ageIndications for Rosuvastatin1.Hypercholesterolemia as an adjunct to diet
2.Mixed dyslipidaemia as an adjunct to diet
Interactions for RosuvastatinRosuvastatin appears to have a low propensity for pharmacokinetic drug interactions. Caution should be exercised in patients receiving concomitant cyclosporin.
Typical Dosage for RosuvastatinOral:
Initially 5mg to 10mg once daily; increased if required at four week intervals based on patient`s response.
Maximum dose: 40mg
Schedule of RosuvastatinHStorage Requirements for RosuvastatinStore at room temperature below 25 degree C.Effects of Missed Dosage of RosuvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of RosuvastatinProvide supportive care and symptomatic treatmentFenofibrate
About FenofibrateFibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.Mechanism of Action of FenofibrateIt is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.Pharmacokinets of FenofibrateAbsorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for FenofibrateN/ADuration of Action for FenofibrateN/AHalf Life of Fenofibrate20 hoursSide Effects of Fenofibrate1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia
Contra-indications of Fenofibrate1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
Special Precautions while taking Fenofibrate1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Fenofibrate1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.Interactions for FenofibrateN/ATypical Dosage for FenofibrateOral: 200mg once daily with food. Adjust the dosage based on patient`s response.Schedule of FenofibrateHStorage Requirements for FenofibrateStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.Effects of Missed Dosage of FenofibrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FenofibrateDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.Home Delivery for Rosuvastatin + Fenofibrate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rosuvastatin + fenofibrate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rosuvastatin + fenofibrate and other medicines and health products. Home delivery services for rosuvastatin + fenofibrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take rosuvastatin + fenofibrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rosuvastatin + fenofibrate before they complete the sale. You can get this information while placing the order for rosuvastatin + fenofibrate with the pharmacy.
Rosuvastatin + Fenofibrate is a generic medicine name and there are several brands available for it. Some of the brands for rosuvastatin + fenofibrate might be better known than rosuvastatin + fenofibrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rosuvastatin + fenofibrate in stock, you can ask for one of the branded alternatives for rosuvastatin + fenofibrate.