Cloxacillin Pharmacology

Cloxacillin

About Cloxacillin
It is a Penicillinase resistant Penicillin, Penicillin derived antibiotic.
Mechanism of Action of Cloxacillin
Cloxacillin is a bactericidal drug. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. In addition to this it is not degraded by penicillinase enzyme and therefore it can be useful against penicillinase producing bacteria also.
Pharmacokinets of Cloxacillin
Absorption .It is readily absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through urine and small amount excreted through breast milk.
Onset of Action for Cloxacillin
30-60 minutes
Duration of Action for Cloxacillin
About 6 hours
Half Life of Cloxacillin
30 minutes
Side Effects of Cloxacillin
1.Anaphylaxis
2.Rash
3.Urticaria
4.Thrombocytopenia
5.Seizure
Contra-indications of Cloxacillin
Hypersensitive to Cloxacillin or other Penicillins.
Special Precautions while taking Cloxacillin
1.Heart failure
2.Uremia
3.Hypokalemia
4 Bleeding tendencies
5.Meningitis
6.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Cloxacillin
1.Urinary tract infections
2.Respiratory tract infections
3.Septicaemia
4.Osteomyelitis
5.Endocarditis
6.Pneumonia
7.Sinusitis
8.Bronchiectasis
Interactions for Cloxacillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Atenolol: Bio-availability of atenolol reduced.
Allopurinol: Increases risk of cloxacillin induced skin rash.
Probenecid: Increases blood levels.
Erythromycin & Tetracyclines: Reduce efficacy.
Clavulanic Acid: Synergy.
Food: Interferes with absorption
Typical Dosage for Cloxacillin
ADULT
1 - 2 g daily in four divided dose depending on the severity of infection
CHILDREN
50 - 100 mg/kg/day in four divided dose depending on the severity of infection
Schedule of Cloxacillin
H
Storage Requirements for Cloxacillin
The vial should be stored in room temperature away from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Cloxacillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose
Effects of Overdose of Cloxacillin
Give supportive measures and symptomatic treatment. Absorption of drug can be reduced by gastric lavage or induction of emesis

Home Delivery for Cloxacillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cloxacillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cloxacillin and other medicines and health products. Home delivery services for cloxacillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cloxacillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cloxacillin before they complete the sale. You can get this information while placing the order for cloxacillin with the pharmacy.

Cloxacillin is a generic medicine name and there are several brands available for it. Some of the brands for cloxacillin might be better known than cloxacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cloxacillin in stock, you can ask for one of the branded alternatives for cloxacillin.