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- Pharmacology For Clomiphene + Co Enzyme Q10
Clomiphene + Co Enzyme Q10 Pharmacology
Clomiphene + Co Enzyme Q10
About Clomiphene + Co Enzyme Q10N/AMechanism of Action of Clomiphene + Co Enzyme Q10Clomifene citrate increases the production of testosterone and enhances sperm production.
Co-enzyme Q10 prevents the sperm destruction due to oxidative stress thereby increases
sperm count and reproductive ability.
Pharmacokinets of Clomiphene + Co Enzyme Q10N/AOnset of Action for Clomiphene + Co Enzyme Q10N/ADuration of Action for Clomiphene + Co Enzyme Q10N/AHalf Life of Clomiphene + Co Enzyme Q10N/ASide Effects of Clomiphene + Co Enzyme Q10N/AContra-indications of Clomiphene + Co Enzyme Q10N/ASpecial Precautions while taking Clomiphene + Co Enzyme Q10N/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra indicatedChildren Related InformationContra indicatedIndications for Clomiphene + Co Enzyme Q10OligospermiaInteractions for Clomiphene + Co Enzyme Q10N/ATypical Dosage for Clomiphene + Co Enzyme Q10As directed by the Physician.Schedule of Clomiphene + Co Enzyme Q10N/AStorage Requirements for Clomiphene + Co Enzyme Q10N/AEffects of Missed Dosage of Clomiphene + Co Enzyme Q10N/AEffects of Overdose of Clomiphene + Co Enzyme Q10N/AClomiphene
About ClomipheneA selective estrogen receptor modulator (SERM),chlorotrianisene derivative, Ovulation Stimulator ,Fertility agent. Mechanism of Action of ClomipheneThe drug is an estrogen antagonist which exerts it`s pharmacological action by inducing ovulation. It induces gonadotropin secretion in women by blocking estrogenic feedback inhibition of pituitary. It increases the amount of LH and FSH released at each secretary pulse which results in enlargement of ovaries and ovulation.
In men increased gonadotropin levels results in increased steroidogenesis and helps in oligospermia and infertility.
Pharmacokinets of ClomipheneAbsorption: Well absorbed orally. Distribution: Distributed preferentially in to the adipose tissue. Metabolism: Metabolized in liver. Excretion: Excreted mainly through bile and faeces.Onset of Action for ClomipheneN/ADuration of Action for ClomipheneN/AHalf Life of Clomiphene5 to 6days.Side Effects of Clomiphene1.Cyts in ovaries
2.Multiple pregnancy
3.Hot flushes
4.Stomach upset
5.Nausea
6 Vomiting
8 Vertigo
9 Breast tenderness
10 Dermatitis
11 Rash
12 Urticaria
13.Increases the risk of ovarian tumor
14 Spotting
15 Alopecia
Contra-indications of Clomiphene1. Hepatic impairment
2. Undiagnosed genital bleeding
3. Ovarian cysts not due to polycystic ovary disease
4. Uncontrolled thyroid dysfunction
5. Uncontrolled adrenal dysfunction
6. Carcinoma of genital tract
7. Pituitary tumor.
Special Precautions while taking Clomiphene1.Therapy for infertility in females should be under direct supervision of a gynaecologist.
2.Ovarian enlargement
3.Long term therapy
4.Along with alcohol
5.Along with antidepressants
Pregnancy Related InformationContraindicatedOld Age Related InformationContraindicatedBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Clomiphene1. Anovulatory infertility
2. Oligomenorrhoea
3. Post pill amenorrhoea
4. Oligospermia
5. Polycystic ovary syndrome
6. Lactation amenorrhoea.
7. Psychogenic amenorrhoea
8. Menorrhagia due to hyper plastic endometrium.
Interactions for ClomipheneGonadotropin Therapy: In combination, Gonadotropin therapy causes hyper-stimulation of ovary.
Lab Tests: Levels of Thyroxine and Thyroxine-binding Globulin (TBG) increased.
BSP (Bromsulphalein) Lab studies: greater than 5% retention of BSP reported in 10-20% of patients.Typical Dosage for ClomipheneOral:
Anovulatory infertility: 50mg once daily for 5days starting from 5th day of menstrual cycle. (Starting from any time in women who have had no recent uterine bleeding). Dose may be increased to 100mg if ovulation does not occur. Repeat the 5 day course until conception occurs or until the completion of 3 courses.
Male infertility: 25mg daily for 25 days followed by a rest period of 5days for 3 to 6 months.
Schedule of ClomipheneN/AStorage Requirements for ClomipheneStore at controlled room temperature at a range of 15 to 30 degree C.in a well closed container. Protect from light, excess heat and moisture.Effects of Missed Dosage of ClomipheneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of ClomipheneProvide symptomatic treatment and supportive measures.Co Enzyme Q10
About Co Enzyme Q101,4-benzoquinone derivative, oil-soluble vitamin-like substance, Enzyme cofactors, powerful antioxidantMechanism of Action of Co Enzyme Q10Coenzyme Q10 is vital for the proper transfer of electrons within the mitochondrial oxidative respiratory chain there it passes reducing equivalents to acceptors such as Coenzyme Q: cytochrome c - oxidoreductase:
CoQH2+ 2 FeIII-cytochrome c ? CoQ + 2 FeII-cytochrome c. main function of this transport is adenosine triphosphate production. Coenzyme Q10 also increases adenosine triphosphate levels by preventing the loss of the adenine nucleotide pool from cardiac cells. Coenzyme Q10 has activity as an antioxidant scavenger and an indirect stabilizer of calcium channels to decrease calcium overload. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Pharmacokinets of Co Enzyme Q10Absorption- Poorly absorbed after oral administration. Excretion- Excreted through bile and fecesOnset of Action for Co Enzyme Q10N/ADuration of Action for Co Enzyme Q10N/AHalf Life of Co Enzyme Q10N/ASide Effects of Co Enzyme Q101. Nausea
2. Vomiting
3. Stomach upset
4. Heartburn
5. Diarrhea
6. Loss of appetite
7. Skin itching
8. Rash
9. Insomnia
10. Headache
11. Dizziness
12. Irritability
13. Increased light sensitivity of the eyes
14. Fatigue
15. Flu-like symptoms
Contra-indications of Co Enzyme Q10N/ASpecial Precautions while taking Co Enzyme Q10N/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Co Enzyme Q101. Dietary supplement
2. Antioxidant
3. Migraine headaches
4. Parkinson`s Disease
5. Mitochondrial Encephalomyopathies
6. Migraine
7. CHF
8. Hypertension
9. Diabetes
10. Cancer
Interactions for Co Enzyme Q10N/ATypical Dosage for Co Enzyme Q10Adult-
Oral-
Mitochondrial cytopathies: 150 mg per day or 2 mg per kg per day with titration up to 3,000 mg per day in some patients
Parkinson`s disease: 300 to 1,200 mg per day in four divided doses
Cardiovascular problems: 50 to 200 mg per day
Migraine 100 to 200 mg per day
Schedule of Co Enzyme Q10N/AStorage Requirements for Co Enzyme Q10Keep tightly closed in a dry place. Do not expose to excessive heat.Effects of Missed Dosage of Co Enzyme Q10Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of Co Enzyme Q10Give supportive measures and symptomatic treatment.Home Delivery for Clomiphene + Co Enzyme Q10 in Your City
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