Clindamycin + Nicotinamide topical Pharmacology

Clindamycin + Nicotinamide topical

About Clindamycin + Nicotinamide topical
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Mechanism of Action of Clindamycin + Nicotinamide topical
Clindamycin is a semisinthetic antibiotic that is effective against P acne bacteria.Nicotinamide is one of the principle forms of B complex,vit.B3(niacin) with marked anti inflammatory activity.it reduces acne lesions,pustules,papules and acne sensitivity.
Pharmacokinets of Clindamycin + Nicotinamide topical
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Onset of Action for Clindamycin + Nicotinamide topical
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Duration of Action for Clindamycin + Nicotinamide topical
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Half Life of Clindamycin + Nicotinamide topical
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Side Effects of Clindamycin + Nicotinamide topical
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Contra-indications of Clindamycin + Nicotinamide topical
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Special Precautions while taking Clindamycin + Nicotinamide topical
Avoid contac with eye.
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Clindamycin + Nicotinamide topical
Management of mil to moderate acne vulgaris and reduction of inflammatory acne lesions.
Interactions for Clindamycin + Nicotinamide topical
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Typical Dosage for Clindamycin + Nicotinamide topical
Apply to the affected area two times a day,wash affected area before use.
Schedule of Clindamycin + Nicotinamide topical
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Storage Requirements for Clindamycin + Nicotinamide topical
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Effects of Missed Dosage of Clindamycin + Nicotinamide topical
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Effects of Overdose of Clindamycin + Nicotinamide topical
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Clindamycin

About Clindamycin
Macrolide, Lincosamide Antibiotic.
Mechanism of Action of Clindamycin
It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis. Along with Quinine sulfate, Clindamycin is used in the treatment of Chloroquine resistant falciparum malaria.
Pharmacokinets of Clindamycin
Absorption: It is well absorbed after oral administration.Distribution: It is very widely distributed in the body as protein bound form.Metabolism: Small amount is metabolized in the liver to inactive compound.Excretion: The drug is excreted through urine and small amount through bile and breast milk.
Onset of Action for Clindamycin
With in minutes
Duration of Action for Clindamycin
6 hour
Half Life of Clindamycin
3 hour
Side Effects of Clindamycin
1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Pseudomembrnous colitis
6.Urticaria
7.Rash
8.Dermatitis
9.Anaphylaxis
10.Leucopenia
11.Eosinophilia
Contra-indications of Clindamycin
1.Hypersensitive to Clindamycin
2.Ulcerative colitis
Special Precautions while taking Clindamycin
1.Hepatic dysfunction
2.Renal impairment
3.Asthma
4.Allergy
Pregnancy Related Information
Contra indicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contra indicated
Children Related Information
Use with caution.
Indications for Clindamycin
1 Intra abdominal abscess
2.Lung abscess
3.Acne
4.Toxoplasmosis
5.Peritonitis
6.Endocarditis
7.Malaria
8.Empyema
9.Skin and soft tissue infection
10.Bacterial vaginosis
Interactions for Clindamycin
Neuromuscular blocking agents: Efficacy of these agents (e.g. tubocurarine) enhanced.
Cholinergics: Effects of neostigmine and pyridostigmine antagonised.
Erythromycin: Antagonism
Typical Dosage for Clindamycin
Adult: 150 - 300 mg four times daily
Severe infection: 300 - 450 mg four times daily
Malaria: 450 mg 3 times daily for 7 days in a regimen with quinine sulfate
Bacterial vaginosis: 300mg twice daily for 7 days
Children:8 - 16 mg / kg body weight/day in 3 - 4 divided dose
Severe infection: 16 - 20 mg/ kg body weight/ day in 3 - 4 divided dose

Schedule of Clindamycin
H
Storage Requirements for Clindamycin
The drug should be store at room temperature.
Effects of Missed Dosage of Clindamycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clindamycin
Give supportive measures and symptomatic treatment.

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Clindamycin + Nicotinamide topical is a generic medicine name and there are several brands available for it. Some of the brands for clindamycin + nicotinamide topical might be better known than clindamycin + nicotinamide topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clindamycin + nicotinamide topical in stock, you can ask for one of the branded alternatives for clindamycin + nicotinamide topical.