Clindamycin + Nicotinamide + Aloe vera + Allantoin Pharmacology

Clindamycin + Nicotinamide + Aloe vera + Allantoin

About Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Mechanism of Action of Clindamycin + Nicotinamide + Aloe vera + Allantoin

Clindamycin is a semisinthetic antibiotic that is effective against P acne bacteria.Nicotinamide is one of the principle forms of B complex,vit.B3(niacin) with marked anti inflammatory activity.it reduces acne lesions,pustules,papules and acne sensitivity.Aloe allantoin base keeps the skin moisturized and smooth.

Pharmacokinets of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Onset of Action for Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Duration of Action for Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Half Life of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Side Effects of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Contra-indications of Clindamycin + Nicotinamide + Aloe vera + Allantoin

N/A

Special Precautions while taking Clindamycin + Nicotinamide + Aloe vera + Allantoin

Avoid contac with eye.

Pregnancy Related Information

Use with caution

Old Age Related Information

May be used

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Clindamycin + Nicotinamide + Aloe vera + Allantoin

Management of mil to moderate acne vulgaris and reduction of inflammatory acne lesions.

Interactions for Clindamycin + Nicotinamide + Aloe vera + Allantoin

N/A

Typical Dosage for Clindamycin + Nicotinamide + Aloe vera + Allantoin

Apply to the affected area two times a day,wash affected area before use.

Schedule of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Storage Requirements for Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Effects of Missed Dosage of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Effects of Overdose of Clindamycin + Nicotinamide + Aloe vera + Allantoin

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Clindamycin

About Clindamycin

Macrolide, Lincosamide Antibiotic.

Mechanism of Action of Clindamycin

It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis. Along with Quinine sulfate, Clindamycin is used in the treatment of Chloroquine resistant falciparum malaria.

Pharmacokinets of Clindamycin

Absorption: It is well absorbed after oral administration.Distribution: It is very widely distributed in the body as protein bound form.Metabolism: Small amount is metabolized in the liver to inactive compound.Excretion: The drug is excreted through urine and small amount through bile and breast milk.

Onset of Action for Clindamycin

With in minutes

Duration of Action for Clindamycin

6 hour

Half Life of Clindamycin

3 hour

Side Effects of Clindamycin

1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Pseudomembrnous colitis
6.Urticaria
7.Rash
8.Dermatitis
9.Anaphylaxis
10.Leucopenia
11.Eosinophilia

Contra-indications of Clindamycin

1.Hypersensitive to Clindamycin
2.Ulcerative colitis

Special Precautions while taking Clindamycin

1.Hepatic dysfunction
2.Renal impairment
3.Asthma
4.Allergy

Pregnancy Related Information

Contra indicated

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Contra indicated

Children Related Information

Use with caution.

Indications for Clindamycin

1 Intra abdominal abscess
2.Lung abscess
3.Acne
4.Toxoplasmosis
5.Peritonitis
6.Endocarditis
7.Malaria
8.Empyema
9.Skin and soft tissue infection
10.Bacterial vaginosis

Interactions for Clindamycin

Neuromuscular blocking agents: Efficacy of these agents (e.g. tubocurarine) enhanced.
Cholinergics: Effects of neostigmine and pyridostigmine antagonised.
Erythromycin: Antagonism

Typical Dosage for Clindamycin

Adult: 150 - 300 mg four times daily
Severe infection: 300 - 450 mg four times daily
Malaria: 450 mg 3 times daily for 7 days in a regimen with quinine sulfate
Bacterial vaginosis: 300mg twice daily for 7 days
Children:8 - 16 mg / kg body weight/day in 3 - 4 divided dose
Severe infection: 16 - 20 mg/ kg body weight/ day in 3 - 4 divided dose

Schedule of Clindamycin

Storage Requirements for Clindamycin

The drug should be store at room temperature.

Effects of Missed Dosage of Clindamycin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Clindamycin

Give supportive measures and symptomatic treatment.

Nicotinamide

About Nicotinamide

Water Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid.

Mechanism of Action of Nicotinamide

Nicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.

Pharmacokinets of Nicotinamide

Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.

Onset of Action for Nicotinamide

N/A

Duration of Action for Nicotinamide

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Half Life of Nicotinamide

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Side Effects of Nicotinamide

1.Activation of peptic ulcer
2.Nausea
3.Vomiting
4.Diarrhoea
5.Headache
6.Hypotension
7.Arrhythmias
8.Hepatic impairment

Contra-indications of Nicotinamide

1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage

Special Precautions while taking Nicotinamide

1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Nicotinamide

1.Pellagra
2.Niacin deficiency
3.Hartnup disease

Interactions for Nicotinamide

N/A

Typical Dosage for Nicotinamide

Pellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Hartnup disease: 50 to 200mg daily in divided doses.

Schedule of Nicotinamide

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Storage Requirements for Nicotinamide

Store at controlled room temperature at a range of 15 to 30 degree C.

Effects of Missed Dosage of Nicotinamide

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nicotinamide

Provide supportive measures and symptomatic treatment.

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Special Precautions while taking

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Typical Dosage for

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Allantoin

About Allantoin

Skin-softening (keratolytic), cell-proliferating healing agent, abrasive and astringent agent.

Mechanism of Action of Allantoin

Allantoin works by slowing bacterial growth and loosing and softening scales and crust.The keratolytic effect and abrasive and astringent properties of Allantoin are used in skin softening cosmetic preparations.
Allantoin is a moisturizing, soothing, healing, anti-irritating, keratolytic and non-toxic agent. Allantoin is a cell-proliferating healing agent which stimulates healthy tissue formation. It removes necrotic and scaling tissue

Pharmacokinets of Allantoin

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Onset of Action for Allantoin

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Duration of Action for Allantoin

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Half Life of Allantoin

N/A

Side Effects of Allantoin

1.Rash
2.Itchy skin

Contra-indications of Allantoin

1.Hypersensitivity to Allantoin
2.Persons allergy to sunlight

Special Precautions while taking Allantoin

1.For external use only

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

May be used

Indications for Allantoin

1.Heal wounds
2.Relieving itching, skin irritations, scaling, dryness, and flaking of the skin due to dandruff, eczema, psoriasis, and seborrhea
3.Stimulate growth of healthy tissue

Interactions for Allantoin

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Typical Dosage for Allantoin

Apply the medicament to the affected area 2 - 3 times daily.

Schedule of Allantoin

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Storage Requirements for Allantoin

Store at room temperature. Keep out of the reach of children.

Effects of Missed Dosage of Allantoin

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.

Effects of Overdose of Allantoin

Give supporive measures and symptomatic treatment.

Home Delivery for Clindamycin + Nicotinamide + Aloe vera + Allantoin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clindamycin + nicotinamide + aloe vera + allantoin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clindamycin + nicotinamide + aloe vera + allantoin and other medicines and health products. Home delivery services for clindamycin + nicotinamide + aloe vera + allantoin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clindamycin + nicotinamide + aloe vera + allantoin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clindamycin + nicotinamide + aloe vera + allantoin before they complete the sale. You can get this information while placing the order for clindamycin + nicotinamide + aloe vera + allantoin with the pharmacy.

Clindamycin + Nicotinamide + Aloe vera + Allantoin is a generic medicine name and there are several brands available for it. Some of the brands for clindamycin + nicotinamide + aloe vera + allantoin might be better known than clindamycin + nicotinamide + aloe vera + allantoin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clindamycin + nicotinamide + aloe vera + allantoin in stock, you can ask for one of the branded alternatives for clindamycin + nicotinamide + aloe vera + allantoin.