Ginkgo Biloba + Vitamin B6 + Folic Acid Pharmacology

Ginkgo Biloba + Vitamin B6 + Folic Acid

About Ginkgo Biloba + Vitamin B6 + Folic Acid
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Mechanism of Action of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Pharmacokinets of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Onset of Action for Ginkgo Biloba + Vitamin B6 + Folic Acid
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Duration of Action for Ginkgo Biloba + Vitamin B6 + Folic Acid
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Half Life of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Side Effects of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Contra-indications of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Special Precautions while taking Ginkgo Biloba + Vitamin B6 + Folic Acid
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Pregnancy Related Information
Not recommended
Old Age Related Information
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Breast Feeding Related Information
Use only when cleaely needed
Children Related Information
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Indications for Ginkgo Biloba + Vitamin B6 + Folic Acid
1.To improve the blood circulation in the brain - in cases of impaired mental function, "dementia" and Alzheimer's disease.
2.In cases in neurogenic depression, intensity, neurosis, migraine, neuralgia.
3.To improve the mental capacity for work and sexual potency.
4.To support the immune system and for prophylactic of aging of tissues and arteriosclerosis
Interactions for Ginkgo Biloba + Vitamin B6 + Folic Acid
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Typical Dosage for Ginkgo Biloba + Vitamin B6 + Folic Acid
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Schedule of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Storage Requirements for Ginkgo Biloba + Vitamin B6 + Folic Acid
At moderate temperature at 15 - 30?C at a place protected from sunlight.
Effects of Missed Dosage of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Effects of Overdose of Ginkgo Biloba + Vitamin B6 + Folic Acid
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Ginkgo Biloba

About Ginkgo Biloba
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Mechanism of Action of Ginkgo Biloba
The mechanism of action of ginkgo is believed to be produced by its functions as a neuroprotective agent, an antioxidant, a free-radical scavenger, a membrane stabilizer, and an inhibitor of platelet-activating factor via the terpene ginkgolide B.Other pharmacologic effects include the following: endothelium relaxation mediated by inhibition of 3',5'-cyclic GMP (guanosine monophosphate) phosphodiesterase; inhibition of age-related loss of muscarinergic cholinoceptors and ?-adrenoceptors; and stimulation of choline uptake in the hippocampus.Ginkgo extract also has been shown to inhibit beta-amyloid deposition.
Pharmacokinets of Ginkgo Biloba
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Onset of Action for Ginkgo Biloba
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Duration of Action for Ginkgo Biloba
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Half Life of Ginkgo Biloba
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Side Effects of Ginkgo Biloba
1.Headaches
2.Dizziness
3.Palpitations
4.GI disturbances
5.Bleeding disorders
6.Skin hypersensitivity reactions
Contra-indications of Ginkgo Biloba
1.Hyper sensitivity
2.Warfarin ,aspirin, antiplatelet agents, herbal medications such as feverfew, garlic, ginseng, dong quai, red clover, and other natural coumarins.
Special Precautions while taking Ginkgo Biloba
1.Patients receiving anticoagulants or drugs that may affect platelet aggregation.
2.The presence of amentoflavone in Gingko biloba leaves would indicate a potential for interactions with many medications through the strong inhibition of CYP3A4 and CYP2C9.
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Ginkgo Biloba
1.Dementia
2.Cerebrovascular and peripheral activator
Interactions for Ginkgo Biloba
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Typical Dosage for Ginkgo Biloba
120 to 240 mg per day, in 2 to 3 doses.
Schedule of Ginkgo Biloba
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Storage Requirements for Ginkgo Biloba
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Effects of Missed Dosage of Ginkgo Biloba
N/A
Effects of Overdose of Ginkgo Biloba
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About
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Mechanism of Action of
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Half Life of
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Contra-indications of
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for
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Typical Dosage for
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Storage Requirements for
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Effects of Missed Dosage of
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Effects of Overdose of
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Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
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Contra-indications of Folic Acid
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Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

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