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- Pharmacology For Sodium Citrate + Citric Acid
Sodium Citrate + Citric Acid Pharmacology
Sodium Citrate + Citric Acid
About Sodium Citrate + Citric AcidN/AMechanism of Action of Sodium Citrate + Citric AcidN/APharmacokinets of Sodium Citrate + Citric AcidN/AOnset of Action for Sodium Citrate + Citric AcidN/ADuration of Action for Sodium Citrate + Citric AcidN/AHalf Life of Sodium Citrate + Citric AcidN/ASide Effects of Sodium Citrate + Citric AcidN/AContra-indications of Sodium Citrate + Citric Acid1.Patients with severe renal impairment.
2.Untreated Addison's disease
3.Severe myocardial damage
Special Precautions while taking Sodium Citrate + Citric Acid1.Excessive doses may cause metabolic alkalosis, especially in patients with hypocalcemia or renal impairment.Possible tetany or depression of the heart associated with decreased ionized calcium concentrations may occur with large doses.
2.Use with extreme caution in patients with low urine output (unless patient is closely supervised), CHF, hypertension, renal dysfunction, peripheral or pulmonary edema, or toxemia of pregnancy.
3.Laxative Effects:Possible saline laxative effects; dilute citrate solution with water and administer after meals to minimize this effect.
Pregnancy Related InformationUse with caution.Old Age Related InformationN/ABreast Feeding Related InformationUse with caution.Children Related InformationN/AIndications for Sodium Citrate + Citric Acid1.Preparations containing sodium citrate and citric acid are especially useful when administration of potassium salts is undesirable or contraindicated.
2.Citrates are used for alkalinization of urine (as alternatives to sodium bicarbonate) in conditions where long-term maintenance of an alkaline urine is desirable.
3.Citrates are used for management of chronic metabolic acidosis associated with conditions such as chronic renal insufficiency or renal tubular acidosis.
4.Citrates are used as adjuvants to uricosuric agents in gout therapy.
5.Sodium citrate and citric acid also used for buffering and neutralizing gastric hydrochloric acid.
6.Sodium citrate has been used to alter cow?s milk so that large hard curds are not formed in the stomach of feeding infants.
Interactions for Sodium Citrate + Citric AcidN/ATypical Dosage for Sodium Citrate + Citric Acid1.Pediatric: Children ?2 years of age: Usually, 5?15 mL of solution, diluted in 30?90 mL of water, after meals and at bedtime.
2.Add 100 mg of sodium citrate to each 30 mL of cow?s milk to prevent hard curds formed in the stomach of feeding infants.
3.Adult: Usually, 10?30 mL of solution,diluted in 30?90 mL of water, after meals and at bedtime.Individualize dosage according to patient?s tolerance and response.
4.Gastric Acid Neutralization: 15 mL of solution, diluted in 15 mL of water, taken as a single dose
Schedule of Sodium Citrate + Citric AcidN/AStorage Requirements for Sodium Citrate + Citric AcidTight, light-resistant containers at 20?25?C; protect from freezing.Effects of Missed Dosage of Sodium Citrate + Citric AcidN/AEffects of Overdose of Sodium Citrate + Citric AcidOverdosage with sodium salts may cause diarrhea, nausea and vomiting, hypernoia, and convulsions.Sodium citrate
About Sodium citrateSodium compound,citrates, Urinary alkalinizing agent, a directly acing expectorant.Mechanism of Action of Sodium citrateSodium citrate is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones and also relieve discomfort in mild urinary tract infections such as cystitis. Sodium citrate also makes the blood more alkaline in certain conditions. Sodium citrate is a directly acing expectorant which increases bronchial secretion by salt action.Pharmacokinets of Sodium citrateAbsorption: Administered orally, Metabolism: Metabolized in to sodium bicarbonate, Excretion: Excreted through urine.Onset of Action for Sodium citrateN/ADuration of Action for Sodium citrateN/AHalf Life of Sodium citrateN/ASide Effects of Sodium citrate1. Polyuria
2. Hypernatremia
3. Metabolic alkalosis
4. Diarrhea
5. Loose bowel movements
6. Allergic reactions (rare)
7. Chest pain (rare)
8. Shortness of breath (rare)
Contra-indications of Sodium citrateHypersensitivity to the drugSpecial Precautions while taking Sodium citrate1. Renal impairment
2. Edema
3. Hypertension
4. Patients on a sodium restricted diet
5. Along with other medication
6. Addison`s disease
7. Type 2 diabetes mellitus
8. Chronic Diarrhea
9. Cardiac diseases
10. Toxemia of pregnancy
11. Urinary tract infections
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Sodium citrate1. Expectorant
2. Kidney stones
3. Cystitis
4. Gout
5. Urine and blood alkaliniser
6. Symptomatic treatment of nausea and vomiting
Interactions for Sodium citrateN/ATypical Dosage for Sodium citrateOral:
Expectorant: 0.3 to 1g
As alkaliniser: Dosage individualized and varies in different combinations Symptomatic treatment of nausea and vomiting: Use 5%Sodium citrate in the following doses:
Adults: 2 to3 g; 3 to 4 times daily.
Children (up to 3 months): 0.05 g;
Children (3 to 6 months): 0.1 g;
Children (6 to 12 months): 0.25 g;
Children (2 to 3 years): 0.30 g;
Children (4 to 7 years): 0.50 g;
Children (8 to 14 years): 1 to 2 g; 3 to 4 times daily
Schedule of Sodium citrateN/AStorage Requirements for Sodium citrateStore in a cool dry area in a tightly closed container. Protect from direct light, heat, and moistureEffects of Missed Dosage of Sodium citrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sodium citrateProvide symptomatic treatment and supportive measures.Citric acid
About Citric acidWeak organic carboxylic acid, an alkalinizing agent, expectorant, antioxidant, flavouring agent.Mechanism of Action of Citric acidCitric acid is an organic acid which is used widely in medicine and also as flavouring agent. Citric acid is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones. It is used in expectorant preparations to increase bronchial secretion. It also posses antioxidant properties.Pharmacokinets of Citric acidAbsorption: Administered orally, Excretion: Excreted through urine.Onset of Action for Citric acidN/ADuration of Action for Citric acidN/AHalf Life of Citric acidN/ASide Effects of Citric acid1 Polyuria
2.Hypernatremia
3.Metabolic alkalosis
4.Diarrhea
5.Loose bowel movements
6.Allergic reactions (rare)
7.Chest pain (rare)
8.Shortness of breath(rare)
Contra-indications of Citric acid1.Hypersensitivity to the drug
2.Patients on sodium-restricted diets
3.Renal impairment with oliguria, azotemia, or anuria
4.Acute dehydration
5.Heat cramps
6.Severe myocardial damage
7.Hyperkalemia.
Special Precautions while taking Citric acid1.Renal impairment
2.Edema
3.Hypertension
4.Along with other medication
5.Addison`s disease
6.Type 2 diabetes mellitus
7.Urolithiasis
8.Cardiac diseases
9.Toxemia of pregnancy
10.Urinary tract infections
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Citric acid1.Expectorant
2.Kidney stones
3.Gout
4.Urine and blood alkaliniser
5.Symptomatic treatment of nausea and vomiting
Interactions for Citric acidN/ATypical Dosage for Citric acidOral:
As alkaliniser: Dosage are individualized and varies in different combinations
Schedule of Citric acidN/AStorage Requirements for Citric acidStore in a cool dry area in a tightly closed container. Protect from direct light, heat, and moisture.Effects of Missed Dosage of Citric acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Citric acidProvide symptomatic treatment and supportive measures.Home Delivery for Sodium Citrate + Citric Acid in Your City
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Sodium Citrate + Citric Acid is a generic medicine name and there are several brands available for it. Some of the brands for sodium citrate + citric acid might be better known than sodium citrate + citric acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sodium citrate + citric acid in stock, you can ask for one of the branded alternatives for sodium citrate + citric acid.