- Medicine India
- Generic Medicines
- D
- Pharmacology For Dicloxacillin + Cefixime
Dicloxacillin + Cefixime Pharmacology
Dicloxacillin + Cefixime
About Dicloxacillin + CefiximeN/AMechanism of Action of Dicloxacillin + CefiximeN/APharmacokinets of Dicloxacillin + CefiximeN/AOnset of Action for Dicloxacillin + CefiximeN/ADuration of Action for Dicloxacillin + CefiximeN/AHalf Life of Dicloxacillin + CefiximeN/ASide Effects of Dicloxacillin + Cefixime1.Nausea
2.Drowsiness
3.Skin rash
4.Diarrhea.
Contra-indications of Dicloxacillin + CefiximeN/ASpecial Precautions while taking Dicloxacillin + CefiximeN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Dicloxacillin + CefiximeTo treat various types of infections.Interactions for Dicloxacillin + CefiximeN/ATypical Dosage for Dicloxacillin + CefiximeN/ASchedule of Dicloxacillin + CefiximeN/AStorage Requirements for Dicloxacillin + CefiximeN/AEffects of Missed Dosage of Dicloxacillin + CefiximeN/AEffects of Overdose of Dicloxacillin + CefiximeN/ADicloxacillin
About DicloxacillinA semisynthetic narrow spectrum beta-lactam antibiotic ofpenicillin class, Penicillinase resistant Antibiotic.Mechanism of Action of DicloxacillinLike other ?-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.Pharmacokinets of DicloxacillinAbsorption :Absorption after oral administration is rapid but incomplete,food delays absorption
Distribution: widespread, highest in kidneys & liver, CSF low
Protein Binding: 96%
Metabolism: hepatic CYP3A4
Excretion: renal, feces
Onset of Action for DicloxacillinN/ADuration of Action for DicloxacillinN/AHalf Life of Dicloxacillin0.7 hourSide Effects of Dicloxacillin1.Diarrhoea
2.Nausea
3.Rash
4.Urticaria
5.Pain and inflammation at injection site
6.Superinfection (including candidiasis)
7.Allergy
8.Transient increases in liver enzymes and bilirubin
Contra-indications of Dicloxacillin1.Hypersensitivity to penicillins,cephalosporins, carbapenems
2.Not to be used in the eye
3.Cholestatic hepatitis associated with the use of dicloxacillin
Special Precautions while taking Dicloxacillin1.Renal impairment
2.Hepatic impairment
Pregnancy Related InformationUse with caution Old Age Related InformationUse with caution Breast Feeding Related InformationExcreted in breast milk, use cautionChildren Related InformationN/AIndications for Dicloxacillin1.Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
2.Staphylococcal skin infections and cellulitis ? including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
3.Pneumonia (adjunct)
4.Osteomyelitis, septic arthritis, throat infections, streptococcus
5.Septicaemia
6.Empirical treatment for endocarditis
7.Surgical prophylaxis
Interactions for Dicloxacillin1.Dicloxacillin decreases anticoagulant effect of warfarin
2.Probenecid prolongs T1/2 of dicloxacillin
3.Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Typical Dosage for DicloxacillinAdult:250 to 500mg in every 6 hours
Paediatric:<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Schedule of DicloxacillinN/AStorage Requirements for DicloxacillinN/AEffects of Missed Dosage of DicloxacillinN/AEffects of Overdose of DicloxacillinN/ACefixime
About CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis Home Delivery for Dicloxacillin + Cefixime in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dicloxacillin + cefixime.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dicloxacillin + cefixime and other medicines and health products. Home delivery services for dicloxacillin + cefixime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dicloxacillin + cefixime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dicloxacillin + cefixime before they complete the sale. You can get this information while placing the order for dicloxacillin + cefixime with the pharmacy.
Dicloxacillin + Cefixime is a generic medicine name and there are several brands available for it. Some of the brands for dicloxacillin + cefixime might be better known than dicloxacillin + cefixime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicloxacillin + cefixime in stock, you can ask for one of the branded alternatives for dicloxacillin + cefixime.