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- Pharmacology For Pantoprazole + Itopride
Pantoprazole + Itopride Pharmacology
Pantoprazole + Itopride
About Pantoprazole + ItoprideN/AMechanism of Action of Pantoprazole + ItoprideN/APharmacokinets of Pantoprazole + ItoprideN/AOnset of Action for Pantoprazole + ItoprideN/ADuration of Action for Pantoprazole + ItoprideN/AHalf Life of Pantoprazole + ItoprideN/ASide Effects of Pantoprazole + ItoprideN/AContra-indications of Pantoprazole + ItoprideN/ASpecial Precautions while taking Pantoprazole + ItoprideN/APregnancy Related InformationContra IndicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra IndicatedChildren Related Information<12 years contra indicatedIndications for Pantoprazole + Itopride1.Duodenal and gastric ulcer
2.Moderate and severe reflux oesophagitis
3.Zollinger-Ellison syndrome
Interactions for Pantoprazole + ItoprideN/ATypical Dosage for Pantoprazole + ItoprideN/ASchedule of Pantoprazole + ItoprideN/AStorage Requirements for Pantoprazole + ItoprideN/AEffects of Missed Dosage of Pantoprazole + ItoprideN/AEffects of Overdose of Pantoprazole + ItoprideN/APantoprazole
About PantoprazoleA proton pump inhibitor, Benzimidazole derivative, Anti ulcer.Mechanism of Action of PantoprazolePantoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available as parenteral form.
Pharmacokinets of PantoprazoleAbsorption: Pantoprazole is well absorbed after oral administration. Its bioavailability is about 77% since it`s undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Pantoprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Pantoprazole2-4 hoursDuration of Action for Pantoprazole1 dayHalf Life of Pantoprazole60 minutesSide Effects of Pantoprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Headache
5. Flatulence
6. Abdominal pain
7. Pruritis
8. Dizziness
9. Rash
Contra-indications of Pantoprazole1. Hypersensitivity to PantoprazoleSpecial Precautions while taking Pantoprazole1. Hepatic impairment
2. Monitor liver function
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
Below 12 years : Contraindicated
Indications for Pantoprazole1. Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
Interactions for PantoprazolePhenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol or ethanol : No clinically relevant interaction at therapeutic doses.
Oral contraceptives : Does not appear to compromise hormonal contraceptive efficacy as no interaction with a low dose combined oral contraceptive has been seen.
Typical Dosage for PantoprazoleOral :
Adult: 20-40mg / day before breakfast.
Duodenal ulcer: 40mg / day to be taken before breakfast for 2 - 4 weeks.
Benign Gastric ulcer: 40mg / day to be taken before breakfast for 1 - 2months.
Zollinger- Ellison syndrome: 80 mg / day in 2 divided doses increase the dose to 240 mg/ day if needed.
Gastroesophageal reflux disease: 20 - 40 mg / day to be taken before breakfast for 1 month and continue the treatment for 1 more month if needed.
Parenteral: 40 mg once daily as IV injection over 15 minutes.
Children below 12 years : Not recommended
Schedule of PantoprazoleHStorage Requirements for PantoprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of PantoprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PantoprazoleGive supportive measures and symptomatic treatment.Itopride
About ItoprideDopamine(D2) antagonist, a prokinetic benzamide derivative, Motility stimulant.Mechanism of Action of ItoprideItopride has three way action. It inhibits the dopamine D2 receptor at the parasympathetic nerve ends.It increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the oesophageal and gastrointestinal peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Itopride exerts anti-emetic actions because of its dopamine D2 receptor antagonistic action at CTZ.
Pharmacokinets of ItoprideAbsorption: it is orally well absorbed after oral administration.Metabolism: Itopride undergoes extensive hepatic metabolism.
Onset of Action for ItoprideN/ADuration of Action for ItoprideN/AHalf Life of Itopride5 - 6 hoursSide Effects of Itopride1.Diarrhoea
2.Abdominal pain
3.Headache
4.Constipation
5.Irritated feeling
6.Giddiness
Contra-indications of Itopride1.Hypersensitivity to Itopride
2.Gastrointestinal haemorrhage
3.Mechanical obstruction or perforation
Special Precautions while taking ItoprideN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below12 years: Contraindicated
Indications for Itopride1.Gastro oesophageal reflux diseases
2.Diabetic Gastroparesis
3.Non ulcer dyspepsia
4.Chronic gastritis
Interactions for ItoprideCisapride, atropine.
Typical Dosage for ItoprideAdult-Oral: 50 mg 3 times daily taken before each meal
Schedule of ItoprideN/AStorage Requirements for ItoprideStore the drug below 30 degree C. Protect from heat and light.Effects of Missed Dosage of ItoprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ItoprideGive supportive measures and symptomatic treatment.Home Delivery for Pantoprazole + Itopride in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pantoprazole + itopride.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pantoprazole + itopride and other medicines and health products. Home delivery services for pantoprazole + itopride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take pantoprazole + itopride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pantoprazole + itopride before they complete the sale. You can get this information while placing the order for pantoprazole + itopride with the pharmacy.
Pantoprazole + Itopride is a generic medicine name and there are several brands available for it. Some of the brands for pantoprazole + itopride might be better known than pantoprazole + itopride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pantoprazole + itopride in stock, you can ask for one of the branded alternatives for pantoprazole + itopride.