Folinic Acid (5-formyl tetrahydrofolate) Pharmacology

Folinic Acid (5-formyl tetrahydrofolate)

About Folinic Acid (5-formyl tetrahydrofolate)

5-formyl tetrahydrofolate Generally administered as calcium or sodium folinate ,is an is one active form in a group of vitamins known as folates.

Mechanism of Action of Folinic Acid (5-formyl tetrahydrofolate)

Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. However, since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate.
Folinic acid, therefore, allows for some purine/pyrimidine synthesis to occur in the presence of dihydrofolate reductase inhibition, so that some normal DNA replication and RNA transcription processes can proceed.

Pharmacokinets of Folinic Acid (5-formyl tetrahydrofolate)

Absorption: Well absorbed (oral, IM).
Distribution: Widely distributed; concentrated in the liver and CSF.
Metabolism: Hepatic, intestinal; converted to biologically active 5-methyltetrahydrofolate.
Excretion: Urine, faeces (small amounts).

Onset of Action for Folinic Acid (5-formyl tetrahydrofolate)

N/A

Duration of Action for Folinic Acid (5-formyl tetrahydrofolate)

N/A

Half Life of Folinic Acid (5-formyl tetrahydrofolate)

N/A

Side Effects of Folinic Acid (5-formyl tetrahydrofolate)

1.Allergic sensitization(rash, pruritus, eythema, urticaria)
2.Nausea
3.Vomiting
4.Pyrexia

Contra-indications of Folinic Acid (5-formyl tetrahydrofolate)

1.Hypersensitivity.
2.Pernicious anaemia and other megaloblastic anaemias secondary to vit B12-deficiency.
3.Intrathecal and intraventricular administration.

Special Precautions while taking Folinic Acid (5-formyl tetrahydrofolate)

1.Do not conceive a child(get pregnant)
2.Undiagnosed megaloblastic anaemia
3.Folate dependent tumors.
4.Monitor calcium levels in patients receiving combined 5-Fluorouracil/Folinic acid treatment.
5.To be given parenterally in the presence of GI toxicity, nausea or vomiting.
6.Monitor serum levels of methotrexate to determine the optimal dose and duration of folinic acid admin.
7.Monitor CBC, electrolytes and liver function tests before and regularly during treatment.

Pregnancy Related Information

Contra indicated

Old Age Related Information

N/A

Breast Feeding Related Information

Contra indicated

Children Related Information

N/A

Indications for Folinic Acid (5-formyl tetrahydrofolate)

1.Antidote for methotrexate toxicity
2.Folate-deficient megaloblastic anaemia
3.Adjunct to fluorouracil in colorectal cancer

Interactions for Folinic Acid (5-formyl tetrahydrofolate)

1.Reduces methotrexate toxicity.
2.Enhances cytotoxic and anti-neoplastic effects of fluorouracil.
3.Increases risk of seizures in epileptic patients treated with primidone, phenytoin, phenobarbital and succinimides.

Typical Dosage for Folinic Acid (5-formyl tetrahydrofolate)

N/A

Schedule of Folinic Acid (5-formyl tetrahydrofolate)

N/A

Storage Requirements for Folinic Acid (5-formyl tetrahydrofolate)

Intravenous: Store at 15-30?C.
Oral: Store at 15-30?C.

Effects of Missed Dosage of Folinic Acid (5-formyl tetrahydrofolate)

N/A

Effects of Overdose of Folinic Acid (5-formyl tetrahydrofolate)

N/A

Home Delivery for Folinic Acid (5-formyl tetrahydrofolate) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including folinic acid (5-formyl tetrahydrofolate).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for folinic acid (5-formyl tetrahydrofolate) and other medicines and health products. Home delivery services for folinic acid (5-formyl tetrahydrofolate) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take folinic acid (5-formyl tetrahydrofolate) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for folinic acid (5-formyl tetrahydrofolate) before they complete the sale. You can get this information while placing the order for folinic acid (5-formyl tetrahydrofolate) with the pharmacy.

Folinic Acid (5-formyl tetrahydrofolate) is a generic medicine name and there are several brands available for it. Some of the brands for folinic acid (5-formyl tetrahydrofolate) might be better known than folinic acid (5-formyl tetrahydrofolate) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have folinic acid (5-formyl tetrahydrofolate) in stock, you can ask for one of the branded alternatives for folinic acid (5-formyl tetrahydrofolate).