Penicillin G Pharmacology

Penicillin G

About Penicillin G
Natural ?-lactamase sensitive pencillin, A narrow spectrum antibiotic.
Mechanism of Action of Penicillin G
It is a bactericidal drug. Penicillin is a Beta lactum antibiotic. It binds to the penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Penicillin is more active against gram positive organism than gram negative organism.
Pharmacokinets of Penicillin G
Absorption:It is well absorbed after IM injection and oral absorption is poor.Distribution:It is very widely distributed in the body. Metabolism: It is metabolized to inactive compound in the body.Excretion: It is excreted mainly through urine and small amount excreted through milk, saliva and bile.
Onset of Action for Penicillin G
15 - 30 minutes
Duration of Action for Penicillin G
3 - 6 hours
Half Life of Penicillin G
30 minutes
Side Effects of Penicillin G
1.Nausea
2.Vomiting
3.Thrombophlebitis
4.Jarisch Herxheimer reaction
5.Pain at the site of injection
6.Diarrhoea
7.Urticaria
8.Rash
9.Anaphylaxis
10.Allergy
11.Erythema
12.Anxiety
13.Mental disturbances
Contra-indications of Penicillin G
Hypersensitive to Penicillin G and other Penicillins
Special Precautions while taking Penicillin G
Renal impairment: monitor renal function and reduce the dose if needed

Pregnancy Related Information
Use with caution
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Penicillin G
1.Meningitis
2.SABE
3.Lung abscess
4.Syphilis
5.Septicemia in children
6.Pneumococcal pneumonia
7.Pericarditis
8.Streptococcal pharyngitis
9.Otitis media
10.Mastoiditis
11.Streptococcal osteomyelitis
12.Gonorrhoea
13.Anthrax
14.Gas gangrene
15.Diphtheria
16.Tetanus
17.Actinomycosis
Interactions for Penicillin G
Aminoglycosides, parenteral: Certain parenteral penicillins may inactivate certain aminoglycosides in vitro - do not mix in the same IV solution.
Anticoagulants: Large IV doses of penicillins prolong bleeding time - chances of bleeding.
Oral contraceptives: Efficacy of oral contraceptives reduced. Additional form of contraception during penicillin therapy is advisable.
Heparin: With parenteral penicillins there is increased risk of bleeding.
Erythromycin: Both synergism and antagonism have been reported.
Allopurinol: Rate of ampicillin-induced skin rash appears much higher when co-administered with allopurinol.
Tetracyclines: Bacteriostatic effects of tetracycline derivatives may impair bactericidal effects of penicillins.
Probenecid: Prolongs half-life of penicillin.
Typical Dosage for Penicillin G
ADULT
ORAL
Bacterial infections: 2-5lac units every 6hourly in divided dose depending on the severity of infection
INJECTION
Bacterial endocarditis: IV infusion 7-8g in divided dose every 6 hourly in a day depending on the severity of infection
Meningococcal disease: IV INFUSION 2-3 g six times a day
CHILDREN
Premature infants and neonates: 100mg/kg daily in two divided dose
Infants (1 month): 150mg/kg thrice daily in divided dose
Child<12 years: 180-300mg/kg 4-6 times daily in divided dose.

Schedule of Penicillin G
H
Storage Requirements for Penicillin G
It should store at temperature below 25 degree Celsius Keep out of the reach of children.
Effects of Missed Dosage of Penicillin G
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Penicillin G
Give supportive measures and symptomatic treatment. The drug can be removed by dialysis.

Home Delivery for Penicillin G in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including penicillin g.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for penicillin g and other medicines and health products. Home delivery services for penicillin g may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take penicillin g only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for penicillin g before they complete the sale. You can get this information while placing the order for penicillin g with the pharmacy.

Penicillin G is a generic medicine name and there are several brands available for it. Some of the brands for penicillin g might be better known than penicillin g itself. If the pharmacy that's willing to deliver medicines to your home doesn't have penicillin g in stock, you can ask for one of the branded alternatives for penicillin g.