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- Pharmacology For Drotaverine + Paracetamol
Drotaverine + Paracetamol Pharmacology
Drotaverine + Paracetamol
About Drotaverine + ParacetamolN/AMechanism of Action of Drotaverine + ParacetamolN/APharmacokinets of Drotaverine + ParacetamolN/AOnset of Action for Drotaverine + ParacetamolN/ADuration of Action for Drotaverine + ParacetamolN/AHalf Life of Drotaverine + ParacetamolN/ASide Effects of Drotaverine + ParacetamolN/AContra-indications of Drotaverine + ParacetamolN/ASpecial Precautions while taking Drotaverine + ParacetamolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Drotaverine + ParacetamolN/AInteractions for Drotaverine + ParacetamolN/ATypical Dosage for Drotaverine + ParacetamolN/ASchedule of Drotaverine + ParacetamolN/AStorage Requirements for Drotaverine + ParacetamolN/AEffects of Missed Dosage of Drotaverine + ParacetamolN/AEffects of Overdose of Drotaverine + ParacetamolN/ADrotaverine
About DrotaverineDrotaverine is an effective spasmolytic drug.Mechanism of Action of DrotaverineDrotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.Pharmacokinets of DrotaverineAbsorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine30 minutesDuration of Action for Drotaverine4 hours.Half Life of Drotaverine7 - 12 hoursSide Effects of Drotaverine1.Hypotension
2.Headache
3.Tachycardia
4.Nausea
5.Vertigo
Contra-indications of Drotaverine1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Drotaverine1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
4.Dysmenorrhoea
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for DrotaverineN/ATypical Dosage for DrotaverineAdult:
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.
Schedule of DrotaverineN/AStorage Requirements for DrotaverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of DrotaverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DrotaverineGive supportive measures and symptomatic treatment.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Drotaverine + Paracetamol in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drotaverine + paracetamol and other medicines and health products. Home delivery services for drotaverine + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take drotaverine + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drotaverine + paracetamol before they complete the sale. You can get this information while placing the order for drotaverine + paracetamol with the pharmacy.
Drotaverine + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for drotaverine + paracetamol might be better known than drotaverine + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotaverine + paracetamol in stock, you can ask for one of the branded alternatives for drotaverine + paracetamol.