Atorvastatin + Ramipril Pharmacology

Atorvastatin + Ramipril

About Atorvastatin + Ramipril
N/A
Mechanism of Action of Atorvastatin + Ramipril
N/A
Pharmacokinets of Atorvastatin + Ramipril
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Onset of Action for Atorvastatin + Ramipril
N/A
Duration of Action for Atorvastatin + Ramipril
N/A
Half Life of Atorvastatin + Ramipril
N/A
Side Effects of Atorvastatin + Ramipril
N/A
Contra-indications of Atorvastatin + Ramipril
1.Active liver disease: cholestasis, hepatic encephalopathy, hepatitis, and jaundice
2.Unexplained elevations in AST or ALT levels
3.Renovascular disease, severe renal impairment
4.History of angioedema while on an ACE inhibitor
Special Precautions while taking Atorvastatin + Ramipril
N/A
Pregnancy Related Information
Contra indicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contra indicated
Children Related Information
N/A
Indications for Atorvastatin + Ramipril
Treatment of patients with both essential hypertension and hypercholesterolemia.
Interactions for Atorvastatin + Ramipril
N/A
Typical Dosage for Atorvastatin + Ramipril
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Schedule of Atorvastatin + Ramipril
N/A
Storage Requirements for Atorvastatin + Ramipril
N/A
Effects of Missed Dosage of Atorvastatin + Ramipril
N/A
Effects of Overdose of Atorvastatin + Ramipril
N/A

Atorvastatin

About Atorvastatin
HMG-CoA Reductase Inhibitor, statins, Antilipemic agent.
Mechanism of Action of Atorvastatin
It is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.
Pharmacokinets of Atorvastatin
Absorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.
Onset of Action for Atorvastatin
N/A
Duration of Action for Atorvastatin
N/A
Half Life of Atorvastatin
18 to 24 hours
Side Effects of Atorvastatin
1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections

Contra-indications of Atorvastatin
1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin

1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever


Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below 9years: Contraindicated
Indications for Atorvastatin
1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for Atorvastatin
N/A
Typical Dosage for Atorvastatin
Oral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of Atorvastatin
H
Storage Requirements for Atorvastatin
Store at room temperature at a range of 15 to 25 degree C.
Effects of Missed Dosage of Atorvastatin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Atorvastatin
Provide supportive care and symptomatic treatment.

Ramipril

About Ramipril
Angiotensin - converting enzyme inhibitor, Antihypertensive.
Mechanism of Action of Ramipril
It is a prodrug and converted in to active Ramiprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
Pharmacokinets of Ramipril
Absorption: Absorbed orally up to 60%, Distribution: Widely distributed in the tissues, Metabolism: Metabolized in the body in to active metabolite, Ramiprilat. Excretion: Excreted mainly through urine and also excreted through faeces.
Onset of Action for Ramipril
1 to 2 hours
Duration of Action for Ramipril
24 hours
Half Life of Ramipril
8 to 48 hours
Side Effects of Ramipril
1.Cough
2.Angioedema
3.Hypotension
4.Chest pain
5.Hyperkalemia
6.Rashes
7.Urticaria
8.Swelling of lips, mouth, nose, and larynx
9.Fetopathic in later half of pregnancy
10.Headache
11.Diarrhoea
12.Fatigue
13.Dizziness
14.Nausea
15.Neutropenia
16.Thrombocytopenia
17.Acute renal failure is precipitated in renal artery stenosis


Contra-indications of Ramipril
1.Hypersensitivity to the drug
2.Renal artery stenosis
3.Aortic stenosis
4.Coarctation of aorta

Special Precautions while taking Ramipril
1.Renal impairment
2.Hepatic impairment
3.Use cautiously in patient at high risk of cardiogenic shock, severe heart failure etc
4.Anaesthesia and surgery

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Ramipril
1.Hypertension
2.Heart failure

Interactions for Ramipril
Antacids: May decrease bioavailability of ramipril.
Phenothiazines: Pharmacologic effects enhanced by phenothiazines.
Allupurinol: Higher risk of hypersensitivity reactions.
Digoxin: Increases plasma digoxin levels.
Potassium preparations & Potassium sparing diuretics: Hyperkalaemia and increased risk of renal failure.
Lithium: Toxicity due to increased serum concentration of lithium.
Typical Dosage for Ramipril
Starts with 1.25mg once daily. Increases the dose to 2.5 to 5mg once daily; depending on patient`s response.
Maximum dose: 10mg once daily.
In CHF patients starts the dosage with 1.5mg once daily dosage and gradually increases at 2 to3 weeks` intervals to usual dosage.

Schedule of Ramipril
H
Storage Requirements for Ramipril
Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.






Effects of Missed Dosage of Ramipril
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ramipril
Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.

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Atorvastatin + Ramipril is a generic medicine name and there are several brands available for it. Some of the brands for atorvastatin + ramipril might be better known than atorvastatin + ramipril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have atorvastatin + ramipril in stock, you can ask for one of the branded alternatives for atorvastatin + ramipril.