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- Pharmacology For Salbutamol + Choline Theophyllinate
Salbutamol + Choline Theophyllinate Pharmacology
Salbutamol + Choline Theophyllinate
About Salbutamol + Choline TheophyllinateN/AMechanism of Action of Salbutamol + Choline TheophyllinateN/APharmacokinets of Salbutamol + Choline TheophyllinateN/AOnset of Action for Salbutamol + Choline TheophyllinateN/ADuration of Action for Salbutamol + Choline TheophyllinateN/AHalf Life of Salbutamol + Choline TheophyllinateN/ASide Effects of Salbutamol + Choline Theophyllinate1.Seizures
2.Tremor
3.Muscle cramps
4.Palpitation
5.Hypokalaemia
6.Headache
7.Anorexia
8.Nausea
9.Anxiety
10.Irritability
11.Insomnia
12.Rarely rash and angioedema.
Potentially Fatal: Arrhythmias including premature ventricular contractions.
Contra-indications of Salbutamol + Choline Theophyllinate1.Hypersensitivity
2.Thyrotoxicosis
Special Precautions while taking Salbutamol + Choline Theophyllinate1.Hepatic impairment
2.Cardiac failure
3.Hypertension
4.Arrhythmias
5.Pulmonary oedema
6.Hyperthyroidism
7.Diabetes mellitus
8.History of peptic ulcer and convulsive disorders
9.Patients on maois or tricyclic antidepressants
10.High fever
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Salbutamol + Choline Theophyllinate1.Bronchial asthma
2.Chronic bronchitis
3.Emphysema
Interactions for Salbutamol + Choline Theophyllinate1.Increased theophylline toxicity with propranolol, cimetidine, erythromycin (7-5 days), quinolone antibiotics.
2.Reduced efficacy with rifampicin, phenobarbitone, phenytoin, carbamazepine, sulfinpyrazone and smoking.
3.Increased risk of hypokalaemia with diuretics.
Potentially Fatal: With anaesthetics, pancuronium bromide and sympathomimetics (increased risk of arrhythmias).
Typical Dosage for Salbutamol + Choline TheophyllinateN/ASchedule of Salbutamol + Choline TheophyllinateN/AStorage Requirements for Salbutamol + Choline TheophyllinateN/AEffects of Missed Dosage of Salbutamol + Choline TheophyllinateN/AEffects of Overdose of Salbutamol + Choline TheophyllinateN/ASalbutamol
About SalbutamolBeta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma), uterine relaxant.Mechanism of Action of SalbutamolSalbutamol is a short acting ?2 receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators. Salbutamol is effective in the management of preterm labour.
Pharmacokinets of SalbutamolAbsorption: It is well absorbed after oral administration.
Distribution: Salbutamol does not cross the blood brain barrier.
Metabolism: It is metabolised to inactive metabolites in the liver
Excretion: Salbutamol is excreted primarily in the urine and small amount in the faeces.
Onset of Action for Salbutamol15 - 30 minutesDuration of Action for Salbutamol6 - 12 hoursHalf Life of Salbutamol4 hoursSide Effects of Salbutamol1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Hypokalaemia (high dose)
Contra-indications of Salbutamol1.Hypersensitivity to Salbutamol and other sympathomimetic amines.Special Precautions while taking Salbutamol1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
Below 6 years: contraindicatedIndications for Salbutamol1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for SalbutamolBeclomethasone, Theophylline: Enhances respiratory function.
Beta-blockers: Inhibit bronchodilator effect.
Diuretics and Xanthines: Increased risk of hypokalemia.
Digitalis: Increased risk of digitalis toxicity when salbutamol is given in hilgh doses due to hypokalaemia.Typical Dosage for SalbutamolAdult:
Oral:
Immediate release tablet: 2 - 4 mg every 6 - 8 hours daily, maximum dose 32mg / day
Sustained release tablets: 8 mg / day in 2 divided doses and if sufficient response does not obtained then dose can be gradually increased to 16mg / day in 2 divided doses
Children: 6 - 14 years
Syrup: 6 - 8mg / day in 3 - 4 divided doses and if needed dose can be increased maximum up to 24mg / day
Uterine Relaxant: (I.V) 4 to 32 mcg/minutes
Schedule of SalbutamolHStorage Requirements for SalbutamolStore at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of SalbutamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SalbutamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.Choline Theophyllinate
About Choline TheophyllinateCholine salt of thophyllinMechanism of Action of Choline TheophyllinateOxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Oxtriphylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.Pharmacokinets of Choline TheophyllinateAbsorption: Well absorbed from GI tract
Metabolism: Hepatic P450 enzyme CYP1A2, CYP3A4
Excretion: Urine
Onset of Action for Choline TheophyllinateN/ADuration of Action for Choline Theophyllinate4-8 hrHalf Life of Choline Theophyllinate4 hr Side Effects of Choline Theophyllinate1.Slight nausea
2.Decreased appetite
3.Weight loss
4.Restlessness
5.Tremor
6.Insomnia
7.Headache
8.Lightheadedness
9.Dizziness.
Contra-indications of Choline TheophyllinateHypersensitivitySpecial Precautions while taking Choline Theophyllinate1.Peptic ulceration
2.Hyperthyroidism
3.Hypertension
4.Cardiac arrhythmias or other cv diseases
5.Epilepsy
6.Hepatic dysfunction
7.Chronic alcoholism
8.Acute febrile illness
9.Smoking
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with caution,use minimum doseChildren Related InformationN/AIndications for Choline TheophyllinateUsed to treat the symptoms of
1.Asthma
2.Bronchitis
3.Emphysema
Interactions for Choline TheophyllinateThe following drugs may increase the levels of oxtriphylline in your blood, leading to dangerous side effects:
1.Alcohol
2.Cimetidine
3.Fluoroquinolone antibiotics such as enoxacin, lomefloxacin,ciprofloxacin, norfloxacin (n, and ofloxacin
4.Clarithromycin and erythromycin
5.Disulfiram
6.Estrogens
7.Fluvoxamine
8.Methotrexate
9.Mexiletine and propafenone
10.Propranolol
11.Tacrine
12.Ticlopidine
13.Verapamil
The following drugs may decrease theophylline levels in your blood, leading to poor asthma control:
1.Aminoglutethimide
2.Carbamazepine
3.Isoproterenol
4.Moricizine
5.Phenobarbital
6.Phenytoin
7.Rifampin
8.Sucralfate
Typical Dosage for Choline Theophyllinate400mg-600mg dailySchedule of Choline TheophyllinateN/AStorage Requirements for Choline TheophyllinateN/AEffects of Missed Dosage of Choline TheophyllinateTake the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.
Effects of Overdose of Choline TheophyllinateSeek emergency medical attention.
Symptoms of a oxtriphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.
Home Delivery for Salbutamol + Choline Theophyllinate in Your City
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Salbutamol + Choline Theophyllinate is a generic medicine name and there are several brands available for it. Some of the brands for salbutamol + choline theophyllinate might be better known than salbutamol + choline theophyllinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have salbutamol + choline theophyllinate in stock, you can ask for one of the branded alternatives for salbutamol + choline theophyllinate.