- Medicine India
- Generic Medicines
- B
- Pharmacology For Beclomethasone Dipropionate + Salbutamol
Beclomethasone Dipropionate + Salbutamol Pharmacology
Beclomethasone Dipropionate + Salbutamol
About Beclomethasone Dipropionate + SalbutamolN/AMechanism of Action of Beclomethasone Dipropionate + SalbutamolN/APharmacokinets of Beclomethasone Dipropionate + SalbutamolN/AOnset of Action for Beclomethasone Dipropionate + SalbutamolN/ADuration of Action for Beclomethasone Dipropionate + SalbutamolN/AHalf Life of Beclomethasone Dipropionate + SalbutamolN/ASide Effects of Beclomethasone Dipropionate + SalbutamolN/AContra-indications of Beclomethasone Dipropionate + SalbutamolN/ASpecial Precautions while taking Beclomethasone Dipropionate + SalbutamolN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Beclomethasone Dipropionate + SalbutamolAsthmaInteractions for Beclomethasone Dipropionate + SalbutamolN/ATypical Dosage for Beclomethasone Dipropionate + SalbutamolAdults: Two inhalations, three or four times daily, titrated to the lowest effective dose
Children: One or two inhalations, two, three or four times daily
Schedule of Beclomethasone Dipropionate + SalbutamolN/AStorage Requirements for Beclomethasone Dipropionate + SalbutamolStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of Beclomethasone Dipropionate + SalbutamolN/AEffects of Overdose of Beclomethasone Dipropionate + SalbutamolN/ABeclomethasone dipropionate
About Beclomethasone dipropionatePotent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.Mechanism of Action of Beclomethasone dipropionateMechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Beclomethasone dipropionateAbsorption: It enters in to the systemic circulation after topical administration.Onset of Action for Beclomethasone dipropionateN/ADuration of Action for Beclomethasone dipropionateN/AHalf Life of Beclomethasone dipropionateN/ASide Effects of Beclomethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Beclomethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionateThere are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionateTopical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected areaSchedule of Beclomethasone dipropionateHStorage Requirements for Beclomethasone dipropionateStore below 25 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Beclomethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beclomethasone dipropionateGive supportive measures and symptomatic treatment.Salbutamol
About SalbutamolBeta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma), uterine relaxant.Mechanism of Action of SalbutamolSalbutamol is a short acting ?2 receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators. Salbutamol is effective in the management of preterm labour.
Pharmacokinets of SalbutamolAbsorption: It is well absorbed after oral administration.
Distribution: Salbutamol does not cross the blood brain barrier.
Metabolism: It is metabolised to inactive metabolites in the liver
Excretion: Salbutamol is excreted primarily in the urine and small amount in the faeces.
Onset of Action for Salbutamol15 - 30 minutesDuration of Action for Salbutamol6 - 12 hoursHalf Life of Salbutamol4 hoursSide Effects of Salbutamol1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Hypokalaemia (high dose)
Contra-indications of Salbutamol1.Hypersensitivity to Salbutamol and other sympathomimetic amines.Special Precautions while taking Salbutamol1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
Below 6 years: contraindicatedIndications for Salbutamol1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for SalbutamolBeclomethasone, Theophylline: Enhances respiratory function.
Beta-blockers: Inhibit bronchodilator effect.
Diuretics and Xanthines: Increased risk of hypokalemia.
Digitalis: Increased risk of digitalis toxicity when salbutamol is given in hilgh doses due to hypokalaemia.Typical Dosage for SalbutamolAdult:
Oral:
Immediate release tablet: 2 - 4 mg every 6 - 8 hours daily, maximum dose 32mg / day
Sustained release tablets: 8 mg / day in 2 divided doses and if sufficient response does not obtained then dose can be gradually increased to 16mg / day in 2 divided doses
Children: 6 - 14 years
Syrup: 6 - 8mg / day in 3 - 4 divided doses and if needed dose can be increased maximum up to 24mg / day
Uterine Relaxant: (I.V) 4 to 32 mcg/minutes
Schedule of SalbutamolHStorage Requirements for SalbutamolStore at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of SalbutamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SalbutamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.Home Delivery for Beclomethasone Dipropionate + Salbutamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including beclomethasone dipropionate + salbutamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for beclomethasone dipropionate + salbutamol and other medicines and health products. Home delivery services for beclomethasone dipropionate + salbutamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take beclomethasone dipropionate + salbutamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for beclomethasone dipropionate + salbutamol before they complete the sale. You can get this information while placing the order for beclomethasone dipropionate + salbutamol with the pharmacy.
Beclomethasone Dipropionate + Salbutamol is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + salbutamol might be better known than beclomethasone dipropionate + salbutamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + salbutamol in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + salbutamol.