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- Pharmacology For Camylofin dihydrochloride + Nimesulide
Camylofin dihydrochloride + Nimesulide Pharmacology
Camylofin dihydrochloride + Nimesulide
About Camylofin dihydrochloride + NimesulideN/AMechanism of Action of Camylofin dihydrochloride + NimesulideN/APharmacokinets of Camylofin dihydrochloride + NimesulideN/AOnset of Action for Camylofin dihydrochloride + NimesulideN/ADuration of Action for Camylofin dihydrochloride + NimesulideN/AHalf Life of Camylofin dihydrochloride + NimesulideN/ASide Effects of Camylofin dihydrochloride + NimesulideN/AContra-indications of Camylofin dihydrochloride + NimesulideN/ASpecial Precautions while taking Camylofin dihydrochloride + NimesulideN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Camylofin dihydrochloride + NimesulidePainful inflammatory conditions associated with muscle spasmsInteractions for Camylofin dihydrochloride + NimesulideN/ATypical Dosage for Camylofin dihydrochloride + NimesulideN/ASchedule of Camylofin dihydrochloride + NimesulideN/AStorage Requirements for Camylofin dihydrochloride + NimesulideN/AEffects of Missed Dosage of Camylofin dihydrochloride + NimesulideN/AEffects of Overdose of Camylofin dihydrochloride + NimesulideN/ACamylofin dihydrochloride
About Camylofin dihydrochlorideSynthetic anticholinergic, direct smooth muscle relaxant.Mechanism of Action of Camylofin dihydrochlorideCamylofin dihydrochloride is a potent antispasmodic and is useful in active phase of labor. It accelerates the rate of cervical dilatation and shortens the duration of active phase of first stage of labor significantly without any undesirable effects on the fetus. It has no effect on the second and third stage of labor and no effect on uterine activity.Pharmacokinets of Camylofin dihydrochlorideN/AOnset of Action for Camylofin dihydrochlorideN/ADuration of Action for Camylofin dihydrochlorideN/AHalf Life of Camylofin dihydrochlorideN/ASide Effects of Camylofin dihydrochloride1. Dryness of mouth
2. Nausea
3. Vomiting
4. Drowsiness
5. Transient tachycardia
Contra-indications of Camylofin dihydrochloride1.Glucoma
2.Urinary retention (adynamic bladder)
3.Mega colon
4.Gastrointestinal haemorrhage
5.Tachyarrythmia.
Special Precautions while taking Camylofin dihydrochloride1.Urinary retention
2.Prostatic enlargement
3.Tachycardia
4.Cardiac insufficiency
5.Paralytic ileus
6.Ulcerative colitis
7.Pylonic stenosis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Camylofin dihydrochloride1.Used as antispasmodic in biliary colic, renal and ureteric colic, dysmenorrhoea, peptic ulcer and chronic enterocolitis.Interactions for Camylofin dihydrochlorideN/ATypical Dosage for Camylofin dihydrochlorideAdult:
As antispasmodics: (IM or IV ) 0.285 to 0.857 mg / kg to be taken every 8 hours
Schedule of Camylofin dihydrochlorideN/AStorage Requirements for Camylofin dihydrochlorideN/AEffects of Missed Dosage of Camylofin dihydrochlorideThe doctor should be informed immediately if a dose is missedEffects of Overdose of Camylofin dihydrochlorideGive supportive measures and symptomatic treatmentNimesulide
About NimesulideCOX-2 selective NSAID, Analgesic,antipyretic.Mechanism of Action of NimesulideThis Non Steroidal Anti Inflammatory Drug reduces prostaglandin synthesis by the inhibition of cyclo oxygenase enzyme2 selectively. This is a weaker inhibition .So it produces weaker analgesic property. Its potent anti-inflammatory activity is due to its action on various stages of inflammation. This leads to the inhibition of super oxide anion formation invitro by activated neutrophil, inhibition of histamine release from tissue mast cells and basophiles. Additionally it also prevents platelet activating factor synthesis and metalloproteinase synthesis thus prevents the breakdown of osteoarthritic human cartilage. It also prevent tumor necrosis factor alpha and thus reduce the formation of cytokines. This drug can activate glucocorticoid receptors in the body.Pharmacokinets of NimesulideAbsorption-Completely absorbed after oral administration.
Distribution-Widely distributed in the body and extensively bind to the plasma proteins i.e.99%.
Metabolism-It is metabolized in liver to its metabolites.4-hydroxyl derivative is its one active metabolite.
Excretion - Excreted via urine and bile.
Onset of Action for Nimesulide30 to 60 minutesDuration of Action for Nimesulide8-10 hoursHalf Life of NimesulideIts plasma half life is long-nearly 2daysSide Effects of Nimesulide1. Nausea
2. Vomiting
3. Diarrhea
4. Heart burn
5. Epigastric pain
6. Pruritis
7. Skin rash
8. Headache
9. Dizziness
10.Somnolence
Contra-indications of Nimesulide1. Hypersensitivity to this drug
2. Active peptic ulcer
3. Hepatic impairment
Special Precautions while taking Nimesulide1. Renal impairment
2. Heart failure
3. Alcohol abuse
4. Colitis
5. Crohns disease
6. Diverticulitis
7. Gastric ulcer
8. Diabetis mellitus
9. Hemarrhoids
10. Hepatic failure
11. Rectal irritation or bleeding
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Nimesulide1. Painful inflammatory conditions associated with -
Musculoskeletal system, Dysmenorrhea, Thrombophlebitis, Gout
2. Dental pain
3. ENT infection
4. Osteoarthritis
5. Rheumatoid arthritis
6. Gynecological disorder
7. Low back pain
8. Post operative pain
9. Fever
Interactions for NimesulideFenofibrate, Salicyclic acid, Valproic acid and Tolbutamide: These drugs displace nimesulide from the plasma binding sites.
Methotrexate and Frusemide: These drugs may be displaced from plasma proteins by nimesulide.
Warfarin: Exercise caution since efficacy may be increased.
Theophylline: Efficacy of slow release theophylline preparations reduced. Typical Dosage for NimesulideOral-
Adults - 100 mg two times daily.
Children - 5mg/kg/day divided in 2 or 3 doses.
Schedule of NimesulideHStorage Requirements for NimesulideStore in cool, dark, dry placeEffects of Missed Dosage of NimesulideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of NimesulideEmpty the stomach if necessary. Symptomatic treatment should be given
Home Delivery for Camylofin dihydrochloride + Nimesulide in Your City
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Camylofin dihydrochloride + Nimesulide is a generic medicine name and there are several brands available for it. Some of the brands for camylofin dihydrochloride + nimesulide might be better known than camylofin dihydrochloride + nimesulide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have camylofin dihydrochloride + nimesulide in stock, you can ask for one of the branded alternatives for camylofin dihydrochloride + nimesulide.