Guaiphenesin + Tripolidine Pharmacology

Guaiphenesin + Tripolidine

About Guaiphenesin + Tripolidine
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Mechanism of Action of Guaiphenesin + Tripolidine
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Pharmacokinets of Guaiphenesin + Tripolidine
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Onset of Action for Guaiphenesin + Tripolidine
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Duration of Action for Guaiphenesin + Tripolidine
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Half Life of Guaiphenesin + Tripolidine
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Side Effects of Guaiphenesin + Tripolidine
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Contra-indications of Guaiphenesin + Tripolidine
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Special Precautions while taking Guaiphenesin + Tripolidine
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Guaiphenesin + Tripolidine
Allergic conditions
Interactions for Guaiphenesin + Tripolidine
Increased sedation with CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytics, sedatives and antipsychotics
Increased antimuscarinic side effects with other antimuscarinic drugs e.g. atropine, TCA and MAOI
May mask signs of ototoxicity caused by aminoglycosides
Typical Dosage for Guaiphenesin + Tripolidine
Adult: 2.5 mg every 4-6 hr. Max: 10 mg daily
Child: 4 mth-<2 yr: 0.313 mg every 4-6 hr; max: 1.252 mg daily
2-<4 yr: 0.625 mg every 4-6 hr; max: 2.5 mg daily
4-<6 yr: 0.938 mg every 4-6 hr; max: 3.744 mg daily
6-<12 yr: 1.25 mg every 4-6 hr; max: 5 mg daily
?12 yr: 2.5 mg every 4-6 hr; max: 10 mg daily
Schedule of Guaiphenesin + Tripolidine
N/A
Storage Requirements for Guaiphenesin + Tripolidine
Store between 15 to 30 degree celcius in a well closed container. Keep out of the reach of children
Effects of Missed Dosage of Guaiphenesin + Tripolidine
N/A
Effects of Overdose of Guaiphenesin + Tripolidine
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Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

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Special Precautions while taking
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Typical Dosage for
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Guaiphenesin + Tripolidine is a generic medicine name and there are several brands available for it. Some of the brands for guaiphenesin + tripolidine might be better known than guaiphenesin + tripolidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have guaiphenesin + tripolidine in stock, you can ask for one of the branded alternatives for guaiphenesin + tripolidine.