TETRACOSACTIDE Pharmacology

TETRACOSACTIDE

About TETRACOSACTIDE
Synthetic Poly peptide, ACTH agonist
Mechanism of Action of TETRACOSACTIDE
Tetracosactide is a synthetic polypeptide which induces hyperplasia and icreases weight of the adrenal glands. It stimulates secretion of the adrenocortical hormones, especially cortisol (hydrocortisone), some mineralocorticoids e.g. corticosterone, and to a lesser extent, androgens. It has little effect on aldosterone secretion which proceeds independently
Pharmacokinets of TETRACOSACTIDE
Absorption: Absorbed after oral administration
Distribution: Mostly by distribution to the adrenal glands and kidneys
Metabolism: Metabolised by serum endopeptidases into inactive oligopeptides and then by aminopeptidases into free amino acids
Excretion: Excreted through urine
Onset of Action for TETRACOSACTIDE
N/A
Duration of Action for TETRACOSACTIDE
N/A
Half Life of TETRACOSACTIDE
3 hrs
Side Effects of TETRACOSACTIDE
1.Sodium and water retention
2.Potassium loss
3.Hypersensitivity reactions
Contra-indications of TETRACOSACTIDE
1.Asthma
2.Cushing?s Syndrome
3.Heart failure
4.Hypersensitivity
Special Precautions while taking TETRACOSACTIDE
1.Renal impairment
2.Heart failure
3.Hepatic failure
4.Epilepsy
5.Migraine
6.Osteoporosis
7.Peptic Ulcer
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for TETRACOSACTIDE
1.Diagnostic aid for investigation of adrenocortical insufficiency
2.Adjunct in rheumatoid arthritis and osteoarthritis
3.Infantile spasms
4.Corticosteroid therapy
Interactions for TETRACOSACTIDE
Increased requirement of antidiabetic and antihypertensive drugs
Increased risk of hypokalaemia with potassium-depleting drugs, amphotericin B or bronchodilator therapy with xanthines or ?2-agonists
Response to anticoagulants may be altered
Effect of antimuscarinics in myasthenia gravis may be decreased
Effects reduced by barbiturates, carbamazepine, phenytoin, primidone, rifampicin. Concentrations increased by oral contraceptives or ritonavir
Typical Dosage for TETRACOSACTIDE
Intramascular or subcutaneous 250 mcg
Intravenous, 250 mcg (0.25 mg), administered over a two-minute period
Intravenous infusion, 250 mcg (0.25 mg), administered at a rate of 40 mcg (0.04 mg) per hour over a six-hour period
Pediatrics: Children up to 2 yrs: Intramuscular, 125 mcg
Adjunct in rheumatoid arthritis and osteoarthrosis and Corticosteroid therapy: 1 mg daily, may give dose every 12 hr in acute/critical conditions. Maintenance: 1 mg every 2-3 days. For good-responders, may reduce dose to 0.5 mg every 2-3 days or 1 mg wkly
Infantile spasms: Intramuscular:Child: ?1 mth: 500 mcg on alternate days, adjust dose according to response
Schedule of TETRACOSACTIDE
N/A
Storage Requirements for TETRACOSACTIDE
Store between 2-8?C. Protect from sunlight.Keep put of the reach of children
Effects of Missed Dosage of TETRACOSACTIDE
N/A
Effects of Overdose of TETRACOSACTIDE
N/A

Home Delivery for TETRACOSACTIDE in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tetracosactide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tetracosactide and other medicines and health products. Home delivery services for tetracosactide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tetracosactide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tetracosactide before they complete the sale. You can get this information while placing the order for tetracosactide with the pharmacy.

TETRACOSACTIDE is a generic medicine name and there are several brands available for it. Some of the brands for tetracosactide might be better known than tetracosactide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tetracosactide in stock, you can ask for one of the branded alternatives for tetracosactide.