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- Pharmacology For Brompheniramine Maleate + Pseudoephedrine
Brompheniramine Maleate + Pseudoephedrine Pharmacology
Brompheniramine Maleate + Pseudoephedrine
About Brompheniramine Maleate + PseudoephedrineN/AMechanism of Action of Brompheniramine Maleate + PseudoephedrineBrompheniramine maleate is an antihistamine with H1-receptor activity; pseudoephedrine, a sympathomimetic amine and isomer of ephedrine, acts as a decongestant in respiratory tract mucous membranes with less vasoconstrictor action than ephedrine in normotensive individualsPharmacokinets of Brompheniramine Maleate + PseudoephedrineN/AOnset of Action for Brompheniramine Maleate + PseudoephedrineN/ADuration of Action for Brompheniramine Maleate + PseudoephedrineN/AHalf Life of Brompheniramine Maleate + PseudoephedrineN/ASide Effects of Brompheniramine Maleate + PseudoephedrineN/AContra-indications of Brompheniramine Maleate + Pseudoephedrine1.Stroke
2.Palpitations
3.Insomnia
Special Precautions while taking Brompheniramine Maleate + Pseudoephedrine1.Impaired hepatic or renal function
2.Prostatic hypertrophy
3.Hyperthyroidism
4.Glaucoma
5.Cardiac disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Brompheniramine Maleate + Pseudoephedrine1.Allergic rhinitis
2.Nasal congestion
3.Vasomotor rhinitis
Interactions for Brompheniramine Maleate + PseudoephedrineN/ATypical Dosage for Brompheniramine Maleate + PseudoephedrineCapsule, long acting:
Children 6-12 years: 1 capsule every 12 hours
Adults and children> 12 yrs: 1-2 capsules every 12 hours
Syrrup
Adult & childn >12 yr 5 mL: 3 times daily
Childn 6-12 yr: 2.5 mL 3 times daily
2-5 yr: 1.25 mL 3 times daily
Schedule of Brompheniramine Maleate + PseudoephedrineN/AStorage Requirements for Brompheniramine Maleate + PseudoephedrineStored in a tightly closed container.Keep out of the reach of childrenEffects of Missed Dosage of Brompheniramine Maleate + PseudoephedrineN/AEffects of Overdose of Brompheniramine Maleate + PseudoephedrineN/ABrompheniramine Maleate
About Brompheniramine MaleateAntihistamins,Alkylamine derivativeMechanism of Action of Brompheniramine MaleateThis has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptor present on bronchi,uterus etc.This inhibits the activation of receptor and corresponding allergic symptoms produced by it.Centrally the drug also has some antimuscarinic activityPharmacokinets of Brompheniramine MaleateAbsorption: Absorbed after oral administration
Distribution: Widely distributed
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for Brompheniramine MaleateN/ADuration of Action for Brompheniramine Maleate4 to 25 hrsHalf Life of Brompheniramine Maleate25 hrsSide Effects of Brompheniramine Maleate1.Sedation
2.Dryness of mouth
3.Dizziness
4.Disturbed coordination
5.Tremor
6.Irritability
7.Insomnia
8.Visual disturbances
9.Nausea
Contra-indications of Brompheniramine Maleate1.Hypersensitivity
2.Porphyria
3.Narrow-angle glaucoma
4.Urinary retention
5.Peptic ulcer
6.Asthma
Special Precautions while taking Brompheniramine Maleate1.Heart disease
2.Liver problem
3.Narrow-angle glaucoma
4.Respiratory impairment
5.Bronchial asthma
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Neonates: ContraindicatedIndications for Brompheniramine Maleate1.Allergic conjunctivitis
2.Allergic rhinitis
3.Dermatitis
4.NSAID associated ulceration
5.Urticaria
Interactions for Brompheniramine MaleateAlcohol and other CNS depressants:Addictive effect
MAOIs:Prolong anticholinergic effect
Anticholinergics(some)&Tricyclic Antidepressants:May have enhanced effect
Typical Dosage for Brompheniramine MaleateOral
Allergic Conditions
Adult: 4-8 mg 3-4 times daily. Individualise dosage according to patient's response and tolerance.
Child: ?3 yr: 0.4-1 mg/kg/ day, given as 4 divided doses. 3-6 yr: 1-2 mg and 6-12 yr: 2-4 mg, doses to be given 3-4 times daily.
Parenteral
Allergic conditions
Adult: 10 mg every 8-12 hr. Dose can be given via SC, IM or slow IV inj. Max: 40 mg/24 hr.
Schedule of Brompheniramine MaleateN/AStorage Requirements for Brompheniramine MaleateStore Below 40?C. Do not Freeze. Protect from Sunlight and Moisture.Keep out of the reach of childrenEffects of Missed Dosage of Brompheniramine MaleateN/AEffects of Overdose of Brompheniramine MaleateN/APseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
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