Dicyclomine + Mefenamic acid + Dimethyl polysiloxane Pharmacology

Dicyclomine + Mefenamic acid + Dimethyl polysiloxane

About Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Mechanism of Action of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Pharmacokinets of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Onset of Action for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Duration of Action for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Half Life of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Side Effects of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Contra-indications of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Special Precautions while taking Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Interactions for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Typical Dosage for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Schedule of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Storage Requirements for Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Effects of Missed Dosage of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Effects of Overdose of Dicyclomine + Mefenamic acid + Dimethyl polysiloxane
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Dicyclomine

About Dicyclomine
Anticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.
Mechanism of Action of Dicyclomine
Dicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.
Pharmacokinets of Dicyclomine
Absorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine
1-2 hours.
Duration of Action for Dicyclomine
4-6 hours.
Half Life of Dicyclomine
1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))
Side Effects of Dicyclomine
1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine
1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Dicyclomine
1. Irritable bowel syndrome
2.Colicky pain
Interactions for Dicyclomine
N/A
Typical Dosage for Dicyclomine
Adult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of Dicyclomine
H
Storage Requirements for Dicyclomine
Store at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of Dicyclomine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dicyclomine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.

Mefenamic Acid

About Mefenamic Acid
NSAID, Analgesic,antiinflammatory.
Mechanism of Action of Mefenamic Acid
Mefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.
Pharmacokinets of Mefenamic Acid
Absorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.
Onset of Action for Mefenamic Acid
1-2 hours.
Duration of Action for Mefenamic Acid
6 hours.
Half Life of Mefenamic Acid
2-4 hours.
Side Effects of Mefenamic Acid
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Flatulence
12.Drowsiness
13.Insomnia
14.Agranulocytosis
15.Aplastic anaemia
16.Thrombocytopenia
17.Dizziness
18.Rash
Contra-indications of Mefenamic Acid
1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
9.Stroke
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid
1.Muscular aches
2.Primary Dysmenorrhoea
3.Headaches
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic Acid
N/A
Typical Dosage for Mefenamic Acid
Adult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.


Schedule of Mefenamic Acid
H
Storage Requirements for Mefenamic Acid
Store Mefenamic acid at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Mefenamic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mefenamic Acid
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Dimethyl polysiloxane

About Dimethyl polysiloxane
A silicone derivative,Anti-foaming agent, Antiflatulent.
Mechanism of Action of Dimethyl polysiloxane
Dimethyl polysiloxane is a silicone derivative which is used in symptomatic treatment of postprandial and postoperative flatulence and abdominal distension.It acts as defoaming agent and eliminates gases from GI tract.It is used in combination with antacids,antispasmodics and digestants.
Pharmacokinets of Dimethyl polysiloxane
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Onset of Action for Dimethyl polysiloxane
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Duration of Action for Dimethyl polysiloxane
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Half Life of Dimethyl polysiloxane
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Side Effects of Dimethyl polysiloxane
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Contra-indications of Dimethyl polysiloxane
Hypersensitivity to Dimethyl Polysiloxane
Special Precautions while taking Dimethyl polysiloxane
Kidney failure
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dimethyl polysiloxane
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethyl polysiloxane
N/A
Typical Dosage for Dimethyl polysiloxane
40 mg tablet to be taken half an hour before food.

Schedule of Dimethyl polysiloxane
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Storage Requirements for Dimethyl polysiloxane
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethyl polysiloxane
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethyl polysiloxane
Give symptomatic and supportive treatment.

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