Lafutidine Pharmacology

Lafutidine

About Lafutidine
H2 receptor antagonist,Antiulcer
Mechanism of Action of Lafutidine
Lafutidine is a H2(Histamine) receptor antagonist.Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP.This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane.Lafutidine reversibly competes with Histamine for binding to H2 receptor on the basolateral membrane of parietal cells and predominantly inhibits basal acid secretion.
Pharmacokinets of Lafutidine
Absorption: Absorbed after oral administration
Distribution: Bound to protein(88%)
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for Lafutidine
Rapid
Duration of Action for Lafutidine
4 to 6 hrs
Half Life of Lafutidine
N/A
Side Effects of Lafutidine
1.Constipation
2.Hyperuricaemia
3.Increase in LFT and total bilirubin
4.Gynaecomastia
5.Anorexia hallucinations
6.Anaphylactic reactions
Contra-indications of Lafutidine
Hypersensitivity to drug
Special Precautions while taking Lafutidine
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Lafutidine
N/A
Interactions for Lafutidine
N/A
Typical Dosage for Lafutidine
Gastric and duodenal ulcers:
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Stomal ulcers:
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Gastric mucosal lesions:
Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient`s age and symptoms
Pre-anaesthetic medication:
Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation
Schedule of Lafutidine
H
Storage Requirements for Lafutidine
Store at room temperature in a closed container.Protect from light. Keep out of the reach of children.
Effects of Missed Dosage of Lafutidine
N/A
Effects of Overdose of Lafutidine
N/A

Home Delivery for Lafutidine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lafutidine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lafutidine and other medicines and health products. Home delivery services for lafutidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lafutidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lafutidine before they complete the sale. You can get this information while placing the order for lafutidine with the pharmacy.

Lafutidine is a generic medicine name and there are several brands available for it. Some of the brands for lafutidine might be better known than lafutidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lafutidine in stock, you can ask for one of the branded alternatives for lafutidine.