- Medicine India
- Generic Medicines
- F
- Pharmacology For Fenofibrate + Metformin
Fenofibrate + Metformin Pharmacology
Fenofibrate + Metformin
About Fenofibrate + MetforminN/AMechanism of Action of Fenofibrate + MetforminN/APharmacokinets of Fenofibrate + MetforminN/AOnset of Action for Fenofibrate + MetforminN/ADuration of Action for Fenofibrate + MetforminN/AHalf Life of Fenofibrate + MetforminN/ASide Effects of Fenofibrate + MetforminN/AContra-indications of Fenofibrate + MetforminN/ASpecial Precautions while taking Fenofibrate + MetforminN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fenofibrate + MetforminN/AInteractions for Fenofibrate + MetforminN/ATypical Dosage for Fenofibrate + MetforminN/ASchedule of Fenofibrate + MetforminN/AStorage Requirements for Fenofibrate + MetforminN/AEffects of Missed Dosage of Fenofibrate + MetforminN/AEffects of Overdose of Fenofibrate + MetforminN/AFenofibrate
About FenofibrateFibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.Mechanism of Action of FenofibrateIt is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.Pharmacokinets of FenofibrateAbsorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for FenofibrateN/ADuration of Action for FenofibrateN/AHalf Life of Fenofibrate20 hoursSide Effects of Fenofibrate1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia
Contra-indications of Fenofibrate1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
Special Precautions while taking Fenofibrate1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Fenofibrate1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.Interactions for FenofibrateN/ATypical Dosage for FenofibrateOral: 200mg once daily with food. Adjust the dosage based on patient`s response.Schedule of FenofibrateHStorage Requirements for FenofibrateStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.Effects of Missed Dosage of FenofibrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FenofibrateDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.Metformin
About MetforminBiguanide derivative, Oral anti-diabetic.Mechanism of Action of MetforminIt is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.Pharmacokinets of MetforminAbsorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.Onset of Action for MetforminN/ADuration of Action for Metformin6 to 8 hoursHalf Life of Metformin1.5 to 3hoursSide Effects of Metformin1. Abdominal pain
2. Nausea
3. Vomiting
4. Anorexia
5. Metalic taste
6. Mild diarrhea
7. Tiredness
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
12. Diarrhoea
13. Flatulence
14. Dermatitis
15. Rashes.
Contra-indications of Metformin1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
8. Alcoholics.
Special Precautions while taking Metformin1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for MetforminNon-insulin dependent diabetes mellitus (as adjunct to diet and exercise).Interactions for MetforminN/ATypical Dosage for MetforminAdults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable. Schedule of MetforminGStorage Requirements for MetforminStore at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of MetforminTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of MetforminProvide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.Home Delivery for Fenofibrate + Metformin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fenofibrate + metformin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fenofibrate + metformin and other medicines and health products. Home delivery services for fenofibrate + metformin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fenofibrate + metformin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fenofibrate + metformin before they complete the sale. You can get this information while placing the order for fenofibrate + metformin with the pharmacy.
Fenofibrate + Metformin is a generic medicine name and there are several brands available for it. Some of the brands for fenofibrate + metformin might be better known than fenofibrate + metformin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fenofibrate + metformin in stock, you can ask for one of the branded alternatives for fenofibrate + metformin.