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- Pharmacology For Dutasteride + Alfuzosin
Dutasteride + Alfuzosin Pharmacology
Dutasteride + Alfuzosin
About Dutasteride + AlfuzosinN/AMechanism of Action of Dutasteride + AlfuzosinN/APharmacokinets of Dutasteride + AlfuzosinN/AOnset of Action for Dutasteride + AlfuzosinN/ADuration of Action for Dutasteride + AlfuzosinN/AHalf Life of Dutasteride + AlfuzosinN/ASide Effects of Dutasteride + AlfuzosinN/AContra-indications of Dutasteride + AlfuzosinN/ASpecial Precautions while taking Dutasteride + AlfuzosinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dutasteride + AlfuzosinN/AInteractions for Dutasteride + AlfuzosinN/ATypical Dosage for Dutasteride + AlfuzosinN/ASchedule of Dutasteride + AlfuzosinN/AStorage Requirements for Dutasteride + AlfuzosinN/AEffects of Missed Dosage of Dutasteride + AlfuzosinN/AEffects of Overdose of Dutasteride + AlfuzosinN/ADutasteride
About DutasterideA 5-alpha-reductase inhibitor, In benign prostatic hyperplasia(BPH),male baldness.Mechanism of Action of DutasterideThis is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5alpha-reductase (an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone which influences the development of prostate gland). This decreasing level of this hormone relieves the symptoms associated with benign prostatic hyperplasia.Pharmacokinets of DutasterideAbsorption - Moderately absorbed after oral administration
Distribution- Widely distributed in the body as protein binding (99%) form
Metabolism- Metabolized in the liver.
Excretion- Excreted via fecal route
Onset of Action for DutasterideN/ADuration of Action for DutasterideN/AHalf Life of Dutasteride5 weeksSide Effects of Dutasteride1. Inability to have or maintain an erection
2. Decrease in sex drive
3. Difficulty ejaculating
4. Breast tenderness or enlargement
Contra-indications of Dutasteride1. Hypersensitivity to the drug
2. Cancer of the prostate
3. Liver disease
4. Problems with urination
Special Precautions while taking Dutasteride1.Dutasteride is intended for use by men only.
2.Take each dose with a full glass of water.
3.Swallow the capsules whole. Do not chew, crush or break the capsules
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Dutasteride1. Benign prostatic hyperplasia (BPH)
2. Male pattern baldness
Interactions for DutasterideN/ATypical Dosage for DutasterideOral-
Adults-
For benign prostatic hyperplasia- 0.5 milligram (mg) once a day
Schedule of DutasterideN/AStorage Requirements for DutasterideStore at room temperature (25 degree C) away from light and moistureEffects of Missed Dosage of DutasterideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DutasterideGive symptomatic and supportive treatmentAlfuzosin
About AlfuzosinPeripherally acting Adrenergic Alpha1 Antagonist, In BPH, Antihypertensive.Mechanism of Action of AlfuzosinThis drug selectively antagonize the post-synaptic alpha1-adrenoreceptors which are located in the prostate; bladder base, bladder neck, prostatic capsule, and prostatic urethra.Pharmacokinets of AlfuzosinAbsorption- Moderately absorbed after oral administration
Distribution- Widely distributed in the body as plasma protein bounded form (82% to 90%)
Metabolism- Metabolized in the liver by oxidation, O-demethylation and N-dealkylation to metabolites (inactive).
Excretion- Excreted through urine and feces
Onset of Action for AlfuzosinN/ADuration of Action for AlfuzosinN/AHalf Life of Alfuzosin10 hoursSide Effects of Alfuzosin1. Dizziness.
2. Fatigue.
3. Headache.
4. Pain.
5. Constipation.
6. Dyspepsia.
7. nausea.
8. Impotence.
9. Upper respiratory tract infection.
10. Bronchitis.
11. Pharyngitis.
12. Sinusitis.
13. Hypotension.
14. Syncope.
15. Chest pain.
16. Priapism.
17. Rash.
18. Tachycardia.
Contra-indications of Alfuzosin1. Hypersensitivity to Alfuzocin or any component of the formulation.
2. Hepatic insufficiency
Special Precautions while taking Alfuzosin1.History of QT prolongation.
2. Renal impairment.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for AlfuzosinBenign Prostatic hyperplasia (BPH)Interactions for AlfuzosinCYP3A4 is the principal hepatic enzyme isoform involved in the metabolism of alfuzosin. Do not co-administer with ketoconazole, itraconazole, or ritonavir. Use with caution with diltiazem,
Cimetidine: Repeated administration of 1 g/day cimetidine increased both alfuzosin Cmax and AUC values by 20%.
Atenolol: The combination of alfuzosin with atenolol may cause significant reductions in mean blood pressure and in mean heart rate.Typical Dosage for AlfuzosinOral-
Adults-
2.5 mg three times daily or 10mg once daily
Schedule of AlfuzosinHStorage Requirements for AlfuzosinStore in a cool dry place.Preotect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of AlfuzosinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AlfuzosinGive symptomatic and supportive treatmentHome Delivery for Dutasteride + Alfuzosin in Your City
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Dutasteride + Alfuzosin is a generic medicine name and there are several brands available for it. Some of the brands for dutasteride + alfuzosin might be better known than dutasteride + alfuzosin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dutasteride + alfuzosin in stock, you can ask for one of the branded alternatives for dutasteride + alfuzosin.