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- Pharmacology For Nebivolol + Amlodipine
Nebivolol + Amlodipine Pharmacology
Nebivolol + Amlodipine
About Nebivolol + AmlodipineN/AMechanism of Action of Nebivolol + AmlodipineN/APharmacokinets of Nebivolol + AmlodipineN/AOnset of Action for Nebivolol + AmlodipineN/ADuration of Action for Nebivolol + AmlodipineN/AHalf Life of Nebivolol + AmlodipineN/ASide Effects of Nebivolol + AmlodipineN/AContra-indications of Nebivolol + AmlodipineN/ASpecial Precautions while taking Nebivolol + AmlodipineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Nebivolol + AmlodipineN/AInteractions for Nebivolol + AmlodipineN/ATypical Dosage for Nebivolol + AmlodipineN/ASchedule of Nebivolol + AmlodipineN/AStorage Requirements for Nebivolol + AmlodipineN/AEffects of Missed Dosage of Nebivolol + AmlodipineN/AEffects of Overdose of Nebivolol + AmlodipineN/ANebivolol
About NebivololThird generation cardio selective beta-1 receptor antagonist, Antihypertensive.Mechanism of Action of NebivololNebivolol is a 3rd generation cardio selective beta-1 receptor antagonist which reduces vascular resistance, acutely lowers arterial blood pressure without depressing left ventricular function and exerts anti hypertensive effects. The drug causes coronary vasodilatation and improves myocardial ischaemia through nitric oxide release.Pharmacokinets of NebivololAbsorption: Well absorbed orally, Distribution: It is distributed in to the body, Metabolism: It is extensively metabolized inside the body give active hydroxyl metabolite. Excretion: Excreted mainly through urine and rest of drug is excreted through faecesOnset of Action for Nebivolol2 to 6hoursDuration of Action for NebivololN/AHalf Life of Nebivolol24hoursSide Effects of Nebivolol1.Dizziness
2.Headache
3.Tiredness
4.Gastrointestinal problems
5.Nausea
6.Rash
7.Fatigue
8.Vomiting
9.Diarrhoea
10.Raynaud`s syndrome
11.Paraesthesia
12.Dyspnoea
13.Oedema
Contra-indications of Nebivolol1.Hypersensitivity to the drug
2.Uncontrolled heart failure
3.Second or third degree heart block
4.Cardiogenic shock
5.Bradycardia
6.Phaeochromocytoma
7.Hepatic impairment
8.Sick sinus syndrome
9.Chronic obstructive pulmonary disorders
10.Metabolic acidosis
11.Hypotension
12.Peripheral vascular disorders
13.Along with Verapamil
Special Precautions while taking Nebivolol1.Cardiac insufficiency
2.First degree heart block
3.Prinzmetal angina
4.Raynaud`s syndrome
5.Renal impairment
6.The drug should be gradually withdraw with caution
7.Chronic obstructive pulmonary diseases
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationContraindicated.Indications for Nebivolol1.HypertensionInteractions for NebivololN/ATypical Dosage for Nebivolol5mg once daily
Patients above 65years of age: Starts with 2.5mg and increases to 5mg based on patient`s response
Renal impairment: Starts with 2.5mg and increases to 5mg based on patient`s response
Schedule of NebivololHStorage Requirements for NebivololStore in a dry place below 25 degree C. Keep out of reach of children
Effects of Missed Dosage of NebivololTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NebivololTreatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption. Treat Bradycardia with atropine. If required administer Isoproterinol with caution; in heart block. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosidesAmlodipine
About AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
2.Prinzmetal`s angina
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.Home Delivery for Nebivolol + Amlodipine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nebivolol + amlodipine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nebivolol + amlodipine and other medicines and health products. Home delivery services for nebivolol + amlodipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nebivolol + amlodipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nebivolol + amlodipine before they complete the sale. You can get this information while placing the order for nebivolol + amlodipine with the pharmacy.
Nebivolol + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for nebivolol + amlodipine might be better known than nebivolol + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nebivolol + amlodipine in stock, you can ask for one of the branded alternatives for nebivolol + amlodipine.