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- Pharmacology For Cefixime + Clavulanic acid
Cefixime + Clavulanic acid Pharmacology
Cefixime + Clavulanic acid
About Cefixime + Clavulanic acidN/AMechanism of Action of Cefixime + Clavulanic acidN/APharmacokinets of Cefixime + Clavulanic acidN/AOnset of Action for Cefixime + Clavulanic acidN/ADuration of Action for Cefixime + Clavulanic acidN/AHalf Life of Cefixime + Clavulanic acidN/ASide Effects of Cefixime + Clavulanic acidN/AContra-indications of Cefixime + Clavulanic acidN/ASpecial Precautions while taking Cefixime + Clavulanic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cefixime + Clavulanic acidN/AInteractions for Cefixime + Clavulanic acidN/ATypical Dosage for Cefixime + Clavulanic acidN/ASchedule of Cefixime + Clavulanic acidN/AStorage Requirements for Cefixime + Clavulanic acidN/AEffects of Missed Dosage of Cefixime + Clavulanic acidN/AEffects of Overdose of Cefixime + Clavulanic acidN/ACefixime
About CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis Clavulanic acid
About Clavulanic acidBeta-Lactamase Inhibitor, Antibiotic resistance reducer to penicillin group.Mechanism of Action of Clavulanic acidN/APharmacokinets of Clavulanic acidN/AOnset of Action for Clavulanic acidN/ADuration of Action for Clavulanic acidN/AHalf Life of Clavulanic acidN/ASide Effects of Clavulanic acidN/AContra-indications of Clavulanic acidN/ASpecial Precautions while taking Clavulanic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Clavulanic acidN/AInteractions for Clavulanic acidN/ATypical Dosage for Clavulanic acidN/ASchedule of Clavulanic acidN/AStorage Requirements for Clavulanic acidN/AEffects of Missed Dosage of Clavulanic acidN/AEffects of Overdose of Clavulanic acidN/AHome Delivery for Cefixime + Clavulanic acid in Your City
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Cefixime + Clavulanic acid is a generic medicine name and there are several brands available for it. Some of the brands for cefixime + clavulanic acid might be better known than cefixime + clavulanic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefixime + clavulanic acid in stock, you can ask for one of the branded alternatives for cefixime + clavulanic acid.