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- Pharmacology For Ceftazidime + Tazobactam
Ceftazidime + Tazobactam Pharmacology
Ceftazidime + Tazobactam
About Ceftazidime + TazobactamN/AMechanism of Action of Ceftazidime + TazobactamN/APharmacokinets of Ceftazidime + TazobactamN/AOnset of Action for Ceftazidime + TazobactamN/ADuration of Action for Ceftazidime + TazobactamN/AHalf Life of Ceftazidime + TazobactamN/ASide Effects of Ceftazidime + TazobactamN/AContra-indications of Ceftazidime + TazobactamN/ASpecial Precautions while taking Ceftazidime + TazobactamN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ceftazidime + TazobactamN/AInteractions for Ceftazidime + TazobactamN/ATypical Dosage for Ceftazidime + TazobactamN/ASchedule of Ceftazidime + TazobactamN/AStorage Requirements for Ceftazidime + TazobactamN/AEffects of Missed Dosage of Ceftazidime + TazobactamN/AEffects of Overdose of Ceftazidime + TazobactamN/ACeftazidime
About CeftazidimeThird Generation Cephalosporin antibiotic, Parenteral antibiotic.Mechanism of Action of CeftazidimeCeftazidime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftazidime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftazidime.It is more active against pseudomonas.Pharmacokinets of CeftazidimeAbsorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not metabolized in the body. Excretion: Excreted mainly through urine & small amount is seen in breast milk.Onset of Action for CeftazidimeSuddenDuration of Action for Ceftazidime8 hoursHalf Life of Ceftazidime1.8 hoursSide Effects of Ceftazidime1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
3.Vaginitis
4.Pruritus
5.Candidiasis
6.Headache
7.Dizziness
8.Seizures
9.Pseudo membranous colitis
10.Nausea
11.Vomiting
12.Elevated liver enzymes
13.Leucopenia
14.Thrombocytopenia
Contra-indications of Ceftazidime1.Hypersensitivity to the drug or other cephalosporins
2.Never administer along with chloramphenicol.
Special Precautions while taking Ceftazidime1.Renal impairment
2.Those allergic to penicillins
3. Neuromuscular disorders
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be used, but arginine containing formulation like ceptaz is contraindicated
Neonates: may be used ,but arginine containing formulation like ceptaz is contraindicated
Indications for Ceftazidime1.Febrile neutropenic patients with haematological malignancies
2.Burn infections
3.Respiratory tract infections
4.Urinogenital tract infections
5.Bone & Joint infections
6.Septicemia
7.CNS infections
8.Skin & wound infections
9.Meningitis.
Interactions for CeftazidimeNo known interaction.Typical Dosage for CeftazidimeAdults: 0.5g to 2gm I.M. or I.V. three times daily.
Children: 30 to 50 mg/kg/day I.M or I.V. three times daily.
Neonates: 30mg/kg I.V. two times daily
Schedule of CeftazidimeHStorage Requirements for CeftazidimeStore in a refrigerator at -20 degree celciousssEffects of Missed Dosage of CeftazidimeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CeftazidimeSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportiveTazobactam
About TazobactamA Penicillanic acid sulfone beta-lactamase inhibitor, penams, To increase the antibacterial activity of penicillins against ?-lactamase?producing organisms.Mechanism of Action of TazobactamTazobactam is a Penicillanic acid sulfone beta lactamase inhibitor.Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Piperacillin.Pharmacokinets of TazobactamN/AOnset of Action for TazobactamN/ADuration of Action for TazobactamN/AHalf Life of TazobactamN/ASide Effects of Tazobactam1.Gastrointestinal disturbances
2.Headache
3.Dizziness
4.Insomnia
5.Rash
6.Pain
7.Hypertension
8.Edema
9.Pruritus
10.Agitation
11.Local reactions
Contra-indications of TazobactamHypersensitivity to TazobactamSpecial Precautions while taking Tazobactam1.Renal impairment
2.Cystic fibrosis
3.Haematopoiesis
4.Monitor electrolytes
5.Discontinue if bleeding disorders occur
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Tazobactam1.Skin infections
2.Pneumonia
3.Postpartum endometritis
4.Pelvic inflammatory disease
5.Appendicitis
6.Peritonitis
Interactions for TazobactamN/ATypical Dosage for TazobactamIV Infusion over 30 minutes.
Adults: 3 to 4 grams of Piperacillin, in combination with 0.375 to 0.5 grams of Tazobactam, every 6 - 8 hours for 7 - 10 days.
Schedule of TazobactamN/AStorage Requirements for TazobactamN/AEffects of Missed Dosage of TazobactamN/AEffects of Overdose of TazobactamN/AHome Delivery for Ceftazidime + Tazobactam in Your City
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