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- Pharmacology For Chlorhexidine + Sodium fluoride Mouth Wash
Chlorhexidine + Sodium fluoride Mouth Wash Pharmacology
Chlorhexidine + Sodium fluoride Mouth Wash
About Chlorhexidine + Sodium fluoride Mouth WashN/AMechanism of Action of Chlorhexidine + Sodium fluoride Mouth WashSodium fluoride increases osteoblast activity and increase bone volume. Adequate incorporation of fluoride into teeth hardens the outer layers of enamel and increases resistances to demineralization. (The bacteria that cause caries produce acid through the fermentation of carbohydrates, which can dissolve the carbonated hydroxyapatite mineral of teeth, a process called demineralization).
Pharmacokinets of Chlorhexidine + Sodium fluoride Mouth WashAbsorption: Sodium fluoride is well absorbed after oral administration.
Distribution: It is widely distributed in body tissues and organs and concentrated mainly in the teeth and bone.
Excretion: It is excreted mainly in the urine. Small amount is also excreted in sweat, milk and intestinal secretions.
Onset of Action for Chlorhexidine + Sodium fluoride Mouth WashN/ADuration of Action for Chlorhexidine + Sodium fluoride Mouth WashN/AHalf Life of Chlorhexidine + Sodium fluoride Mouth WashN/ASide Effects of Chlorhexidine + Sodium fluoride Mouth Wash1. Gastric distress
2. Atopic dermatitis
3. Eczema
4. Urticaria
Contra-indications of Chlorhexidine + Sodium fluoride Mouth Wash1. Hypersensitivity to Sodium fluoride
2. Fluoride content in water is more than 0.6 ppm
Special Precautions while taking Chlorhexidine + Sodium fluoride Mouth WashDo not eat, drink or rinse mouth for 15 - 30 minutes after application.Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Chlorhexidine + Sodium fluoride Mouth Wash1. OtosclerosisInteractions for Chlorhexidine + Sodium fluoride Mouth WashN/ATypical Dosage for Chlorhexidine + Sodium fluoride Mouth WashAdult: 3 - 4 mg / day
Children:
0.25 - 1 mg / day depending up on the age of the patient, dose is adjusted.
6 months - 3 years: 0.25 mg / day
3 years - 6 years: 0.5 mg / day
6 - 16 years: 1 mg / day
Schedule of Chlorhexidine + Sodium fluoride Mouth WashN/AStorage Requirements for Chlorhexidine + Sodium fluoride Mouth WashStore at 15 - 30 degree C in a tightly closed light resistant container. Keep out of the reach of children.Effects of Missed Dosage of Chlorhexidine + Sodium fluoride Mouth WashTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chlorhexidine + Sodium fluoride Mouth WashGive supportive measures and symptomatic treatment.Chlorhexidine
About ChlorhexidineA bisbiguanide antimicrobial agent, Anti-infective, antiseptic.Mechanism of Action of ChlorhexidineThis drug has positive charge so it attach to the negative charge cell wall. This destabilizes and destroys the integrity and penetrates bacterial cell membranes. It results precipitation of the cytoplasm and interferes with membrane function by inhibiting oxygen utilization leading to a decrease in cellular ATP levels and cell death. In gram-negative bacteria, chlorhexidine affects the outer membrane allowing the release of periplasmic enzymes. The inner membrane of these organisms is not ruptured but the uptake of small molecules is impaired. At low concentrations chlorhexidine exhibits a bacteriostatic effect while at high concentrations it is bactericidal.Pharmacokinets of ChlorhexidineAbsorption- Poorly from the gastrointestinal tract.
Distribution- 87% bound to the plasma proteins.
Excretion- Excreted through feces.
Onset of Action for ChlorhexidineN/ADuration of Action for ChlorhexidineN/AHalf Life of ChlorhexidineN/ASide Effects of Chlorhexidine1. Bleeding
2. Tender
3. Enlarged gums
4. Cough
5. Congestion or tightness in chest
6. Wheezing
7. Staining of teeth
8. Calculus formation above the gum line
Contra-indications of Chlorhexidine1. Hypersensitivity to the drugSpecial Precautions while taking Chlorhexidine1. Avoid eating or drinking for at least 1 hour after each dose
2. To minimize the staining apply drug with the hollow cup brush tip of the Rota-dent perio tool to only the gum tissue, especially focus on the areas with pockets depths over 4mm
3. You may also alternate drug with custom bleaching trays at home
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Chlorhexidine1. Gingivitis
2. Acute and chronic otitis externa (ear infection/inflammation)
3. Periodontal disease
4. Superficial skin infections
5. Irrigation (cleansing) of wounds and as a medicated shampoo for the treatment of certain skin conditions (hot spots or acute moist dermatitis
Interactions for ChlorhexidineN/ATypical Dosage for ChlorhexidineOral rinse solutions - 0.1 percent.
Otic (ear) solutions - 1 percent.
Chlorhexidine solutions - 2 percent.
Chlorhexidine shampoo and conditioner 1 and 2 percent.
As an ear-cleansing agent - flush the ear canal once a day in cases of diagnosed otitis externa.
For skin conditions - clean the area twice daily.
For gingivitis - Chlorhexidine oral solution is applied as directed once a day. In the morning brush and floss for 2 minutes and than rinse with Chlorhexidine for 30 seconds.
Use 1/2 fl. oz. of undiluted. Swish in mouth for 30 seconds. After rinsing for 30 seconds be sure to spit out all the rinse, do NOT swallow any of the rinse. To minimize medicinal taste, DO NOT rinse with water immediately after use. In the evening brush and floss and rinse again for 30 seconds.
Chlorhexidine shampoo and conditioner - once or twice a week.
Pellet (extended-release), Periochip (in a biodegradable matrix of hydrolyzed gelatin cross-linked with glutaraldehyde), Cream, Dressing, Gel, Lotion, Ointment, Sponge forms are also available.
Schedule of ChlorhexidineN/AStorage Requirements for ChlorhexidineStore at room temperature below 77 degree F. Do not freeze.Effects of Missed Dosage of ChlorhexidineTake any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.Effects of Overdose of ChlorhexidineGive symptomatic and supportive treatment.Sodium fluoride Mouth Wash
About Sodium fluoride Mouth WashTopical teeth preparation, Fluorides, Prophylaxis of dental caries.Mechanism of Action of Sodium fluoride Mouth WashSodium fluoride increases osteoblast activity and increase bone volume. Adequate incorporation of fluoride into teeth hardens the outer layers of enamel and increases resistances to demineralization. (The bacteria that cause caries produce acid through the fermentation of carbohydrates, which can dissolve the carbonated hydroxyapatite mineral of teeth, a process called demineralization).
Sodium fluoride acts systemically (before tooth eruption) and topically (post eruption) by increasing tooth resistance to acid dissolution, by promoting remineralization, by inhibiting the cariogenic microbial process and by inhibiting bacterial enzymes. Incorporation of fluoride into apatite crystals reduces the dissolution of apatite during acid attacks. Fluoride interacts with hydroxyapatite to form the less acid soluble fluorhydroxyapatite. Fluorhydroxyapatite is more resistant to dissolution by the acids produced by bacteria found in plaque. Fluoride may also promote the remineralization of enamel in early caries. Finally fluoride may reduce oral concentrations of cariogenic bacteria or reduce the metabolism of bacteria in plaque.Pharmacokinets of Sodium fluoride Mouth WashPharmaco Kinetic
Absorption: Sodium fluoride is well absorbed after oral administration.
Distribution: It is widely distributed in body tissues and organs and concentrated mainly in the teeth and bone.
Excretion: It is excreted mainly in the urine. Small amount is also excreted in sweat, milk and intestinal secretions.
Onset of Action for Sodium fluoride Mouth WashN/ADuration of Action for Sodium fluoride Mouth WashN/AHalf Life of Sodium fluoride Mouth WashN/ASide Effects of Sodium fluoride Mouth Wash1. Gastric distress
2. Staining of teeth
3. Eczema
4. Urticaria
5. Atopic dermatitis
Contra-indications of Sodium fluoride Mouth Wash1. Hypersensitivity to Sodium fluoride
2. Fluoride content in water is more than 0.6 ppm
Special Precautions while taking Sodium fluoride Mouth WashDo not eat, drink or rinse mouth for 15 - 30 minutes after application.Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Sodium fluoride Mouth Wash1. Dental cariesInteractions for Sodium fluoride Mouth WashN/ATypical Dosage for Sodium fluoride Mouth WashAdult: 3 - 4 mg / day
Oral solutions (Sodium fluoride 0.2%fluoride ion) Rinse the mouth with 10 ml of the solution once daily after thoroughly brushing teeth. Rinse for 1 minute then spit out.
Children:
0.25 - 1 mg / day depending up on the age of the patient, dose is adjusted.
6 months - 3 years: 0.25 mg / day
3 years - 6 years: 0.5 mg / day
6 - 16 years: 1 mg / daySchedule of Sodium fluoride Mouth WashN/AStorage Requirements for Sodium fluoride Mouth WashStore at 15 - 30 degree C in a tightly closed light resistant container. Keep out of the reach of children.Effects of Missed Dosage of Sodium fluoride Mouth WashTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Sodium fluoride Mouth WashGive supportive measures and symptomatic treatment.Home Delivery for Chlorhexidine + Sodium fluoride Mouth Wash in Your City
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Chlorhexidine + Sodium fluoride Mouth Wash is a generic medicine name and there are several brands available for it. Some of the brands for chlorhexidine + sodium fluoride mouth wash might be better known than chlorhexidine + sodium fluoride mouth wash itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chlorhexidine + sodium fluoride mouth wash in stock, you can ask for one of the branded alternatives for chlorhexidine + sodium fluoride mouth wash.