Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline Pharmacology

Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

About Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Mechanism of Action of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Pharmacokinets of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Onset of Action for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Duration of Action for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Half Life of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Side Effects of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Contra-indications of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Special Precautions while taking Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Interactions for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Typical Dosage for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Schedule of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Storage Requirements for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Effects of Missed Dosage of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Effects of Overdose of Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline

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Vitamin C

About Vitamin C

Water soluble vitamin, antioxidant.

Mechanism of Action of Vitamin C

Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.

Pharmacokinets of Vitamin C

Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.

Onset of Action for Vitamin C

N/A

Duration of Action for Vitamin C

N/A

Half Life of Vitamin C

N/A

Side Effects of Vitamin C

1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria

Contra-indications of Vitamin C

No known contraindications

Special Precautions while taking Vitamin C

1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used

Indications for Vitamin C

1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C

Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.

Typical Dosage for Vitamin C

Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C

C1 (Oral)
C (Parenteral)

Storage Requirements for Vitamin C

Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.

Effects of Missed Dosage of Vitamin C

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin C

Discontinue the therapy and provide symptomatic and supportive measures.

Vitamin E

About Vitamin E

N/A

Mechanism of Action of Vitamin E

Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.

Pharmacokinets of Vitamin E

Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.

Onset of Action for Vitamin E

N/A

Duration of Action for Vitamin E

N/A

Half Life of Vitamin E

N/A

Side Effects of Vitamin E

1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence

Contra-indications of Vitamin E

1. Hypersensitivity to the drug
2. Should not administer intravenously

Special Precautions while taking Vitamin E

1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens

Pregnancy Related Information

May be used

Old Age Related Information

N/A

Breast Feeding Related Information

May be used

Children Related Information

N/A

Indications for Vitamin E

1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant

Interactions for Vitamin E

Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E

Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.

Schedule of Vitamin E

Storage Requirements for Vitamin E

Store in a well closed container in a cool dry place. Protect from light.

Effects of Missed Dosage of Vitamin E

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin E

Provide supportive measures and symptomatic treatment.

Selenium

About Selenium

A vital antioxidant, selenium acts with vitamin E to protect the immune system and maintain healthy heart function. It is needed for pancreatic function and tissue elasticity and has been shown to protect against radiation and toxic minerals. High levels of heart disease are associated with selenium-deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China. Best sources are butter, Brazil nuts, seafood and grains grown in selenium-rich soil.

Mechanism of Action of Selenium

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Pharmacokinets of Selenium

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Onset of Action for Selenium

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Duration of Action for Selenium

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Half Life of Selenium

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Side Effects of Selenium

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Contra-indications of Selenium

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Special Precautions while taking Selenium

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Selenium

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Interactions for Selenium

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Typical Dosage for Selenium

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Schedule of Selenium

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Storage Requirements for Selenium

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Effects of Missed Dosage of Selenium

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Effects of Overdose of Selenium

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DL-methionine

About DL-methionine

A dietary supplement ,essential amino acid (a-amino acid), Urinary acidifier, antidote (to acetaminophen overdose).

Mechanism of Action of DL-methionine

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Pharmacokinets of DL-methionine

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Onset of Action for DL-methionine

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Duration of Action for DL-methionine

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Half Life of DL-methionine

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Side Effects of DL-methionine

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Contra-indications of DL-methionine

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Special Precautions while taking DL-methionine

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for DL-methionine

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Interactions for DL-methionine

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Typical Dosage for DL-methionine

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Schedule of DL-methionine

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Storage Requirements for DL-methionine

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Effects of Missed Dosage of DL-methionine

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Effects of Overdose of DL-methionine

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Vit B6

About Vit B6

Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.

Mechanism of Action of Vit B6

Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.

Pharmacokinets of Vit B6

Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver

Onset of Action for Vit B6

N/A

Duration of Action for Vit B6

N/A

Half Life of Vit B6

15-20 days

Side Effects of Vit B6

1. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia

Contra-indications of Vit B6

1. Hypersensitivity to Vitamin B6

Special Precautions while taking Vit B6

N/A

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES: Contraindicated

Indications for Vit B6

1. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning

Interactions for Vit B6

Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.

Typical Dosage for Vit B6

Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.

Schedule of Vit B6

N/A

Storage Requirements for Vit B6

Store it at 15 - 30 degree C. Protect from moisture and heat.

Effects of Missed Dosage of Vit B6

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vit B6

Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.

Vit B12

About Vit B12

N/A

Mechanism of Action of Vit B12

Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.

Pharmacokinets of Vit B12

Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.

Onset of Action for Vit B12

N/A

Duration of Action for Vit B12

N/A

Half Life of Vit B12

N/A

Side Effects of Vit B12

1. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema

Contra-indications of Vit B12

1. Hypersensitivity to the drug
2. Leber`s disease

Special Precautions while taking Vit B12

1. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

Use with caution
NEONATES : Use with caution

Indications for Vit B12

1. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)

Interactions for Vit B12

N/A

Typical Dosage for Vit B12

I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.

Schedule of Vit B12

Storage Requirements for Vit B12

Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.

Effects of Missed Dosage of Vit B12

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vit B12

Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.

Folic Acid

About Folic Acid

Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.

Mechanism of Action of Folic Acid

Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.

Pharmacokinets of Folic Acid

Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.

Onset of Action for Folic Acid

Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes

Duration of Action for Folic Acid

Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours

Half Life of Folic Acid

N/A

Side Effects of Folic Acid

N/A

Contra-indications of Folic Acid

N/A

Special Precautions while taking Folic Acid

1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

May be used

Indications for Folic Acid

1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue

Interactions for Folic Acid

1. Hypersensitivity reactions with injection form
2. Bronchospasm

Typical Dosage for Folic Acid

Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.

Schedule of Folic Acid

C1 (Oral)
C (Parenteral)

Storage Requirements for Folic Acid

Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.

Effects of Missed Dosage of Folic Acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Folic Acid

Relatively non toxic. Provide symptomatic treatment and supportive measures.

Choline

About Choline

A water-soluble essential nutrient, natural quaternary saturated amine.

Mechanism of Action of Choline

Choline is a water-soluble vitamin. Choline aids in nerve transmission and utilization of fat and hormone production. It also maintain normal kidney and bladder function.
It is most effective with Vitamin A, B-Complex, B-12, Folic Acid, and Inositol. Also, it helps lower cholesterol, transferring nerve impulse to the brain, helps against memory loss and senile dementia, and aids the liver in removing poisons and drugs from the bloodstream.

Pharmacokinets of Choline

Absorption: Choline is readily absorbed throughout the small intestine.

Onset of Action for Choline

N/A

Duration of Action for Choline

N/A

Half Life of Choline

N/A

Side Effects of Choline

1.Breathing problems
2.Chest pain
3.Skin hives
4.Rash
5.Upset stomach

Contra-indications of Choline

Hypersensitivity to Choline

Special Precautions while taking Choline

N/A

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used

Indications for Choline

1.Headache
2.Head injury
3.Hemiplegia
4.Memory loss
5.Neurological dysfunction
6.Seizure
7.Stroke
8.Tardive dyskinesia

Interactions for Choline

N/A

Typical Dosage for Choline

300mg, 3 times a day.

Schedule of Choline

N/A

Storage Requirements for Choline

Store in cool (<30 degree C) and dark place

Effects of Missed Dosage of Choline

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Choline

Give symptomatic and supportive treatment

Home Delivery for Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline and other medicines and health products. Home delivery services for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline before they complete the sale. You can get this information while placing the order for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline with the pharmacy.

Vitamin C + Vitamin E + Selenium + DL-methionine + Vit B6 + Vit B12 + Folic Acid + Choline is a generic medicine name and there are several brands available for it. Some of the brands for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline might be better known than vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline in stock, you can ask for one of the branded alternatives for vitamin c + vitamin e + selenium + dl-methionine + vit b6 + vit b12 + folic acid + choline.