Propantheline Bromide Pharmacology

Propantheline Bromide

About Propantheline Bromide
Parasympatholytic, Quaternary Antimuscarinic, Antispasmodic.
Mechanism of Action of Propantheline Bromide
Propantheline bromide is an anticholinergic drug. It exerts its action by inhibiting muscarinic (cholinergic) receptors on smooth muscles of gastrointestinal tract, bladder and cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome, reduces gastric motility and decreases gastric acid secretions. It also posses nicotinic blocking activity and interferes with ganglionic or neuromuscular transmission.
Pharmacokinets of Propantheline Bromide
Absorption: Propantheline bromide is poorly absorbed, only about 10 - 25 % after oral administration.
Distribution: It does not penetrate CNS and eye.
Metabolism: It is extensively metabolised in the small intestine (by hydrolysis) and in the liver to inactive metabolites.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Propantheline Bromide
30 - 60 minutes
Duration of Action for Propantheline Bromide
6 hours
Half Life of Propantheline Bromide
1.3 - 2.1 hours
Side Effects of Propantheline Bromide
1. Dry mouth
2. Nausea
3. Vomiting
4. Constipation
5. Blurred vision
6. Urinary hesitancy
7. Urine retention
8. Palpitation
9. Tachycardia
10. Headache
11. Drowsiness
12. Dizziness
13. Confusion
14. Decreased sweating
15. Urticaria
Contra-indications of Propantheline Bromide
1. Hypersensitivity to Propantheline bromide and other anticholinergic drugs
2. Narrow angle glaucoma
3. Obstructive gastro intestinal tract
4. Obstructive uropathy
5. Intestinal atony
6. Paralytic ileus
7. Severe ulcerative colitis
8. Myasthenia gravis
9. Toxic megacolon in ulcerative colitis
10.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Propantheline Bromide
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Arrhythmia
5.Hypertension
6.Coronary artery disease
7.Prostatic hypertrophy
8.Hiatus hernia associated with reflux oesophagitis
9.Hyperthyroidism
10.Pyloric stenosis
11.Any work that requires mental alertness like driving, operating machine or other works
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Propantheline Bromide
1. Peptic ulcer
2. Gastritis
3. Irritable bowel syndrome
4. Renal colic
5. Symptomatic treatment of ulcerative colitis, diverticulitis, cholecystitis
6. Gastrointestinal diagnostic procedures
7. Enuresis(bed wetting) in adults
Interactions for Propantheline Bromide
Amantadine: Increase in anticholinergic side effects.
Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced.
Phenothiazines: Decreases antipsychotic activity, and increases anticholinergic activity.
TCAs: Increased anticholinergic side effects (dry mouth, constipation, urinary retention).
Typical Dosage for Propantheline Bromide
Adult: 60 - 120 mg / day in 4 divided doses
Peptic ulcer: 75 mg / day(15 mg 3 times daily ? hour before each meal and 30 mg at bed time).
Gastrointestinal diagnostic procedures: 30 mg should be given 45 minutes before procedure.
Enuresis in adult: 15 - 30 mg 2 - 3 times daily.
Children: not recommended.
Schedule of Propantheline Bromide
H
Storage Requirements for Propantheline Bromide
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Propantheline Bromide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Propantheline Bromide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. For the reversal of overdose symptoms of Propantheline bromide, Physostigmine 0.5 - 2 mg is given as intravenous injection.

Home Delivery for Propantheline Bromide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including propantheline bromide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for propantheline bromide and other medicines and health products. Home delivery services for propantheline bromide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take propantheline bromide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for propantheline bromide before they complete the sale. You can get this information while placing the order for propantheline bromide with the pharmacy.

Propantheline Bromide is a generic medicine name and there are several brands available for it. Some of the brands for propantheline bromide might be better known than propantheline bromide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have propantheline bromide in stock, you can ask for one of the branded alternatives for propantheline bromide.