Oxyphenonium Pharmacology

Oxyphenonium

About Oxyphenonium
Antimuscarinic ,Quaternary ammonium compound, Mydriatic,Antispasmodic,antiulcer.
Mechanism of Action of Oxyphenonium
Oxyphenonium is an anticholinergic drug. It exerts its action by inhibiting muscarinic (cholinergic) receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.
Oxyphenonium also has a direct relaxant effect on smooth muscle. It also inhibits gastrointestinal propulsive movement and decreases gastric acid secretion and control bronchial, pharyngeal and tracheal secretions
It also posses nicotinic blocking activity and interferes with ganglionic or neuromuscular transmission. It cross the BBB poorly and does not produce CNS effect.
Pharmacokinets of Oxyphenonium
Absorption: Oxyphenonium is rapidly absorbed after oral administration.
Distribution: It is distributed mainly to kidney, liver and small intestine
Metabolism: It is slowly metabolised in the liver.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Oxyphenonium
N/A
Duration of Action for Oxyphenonium
N/A
Half Life of Oxyphenonium
N/A
Side Effects of Oxyphenonium
1. Dry mouth
2. Nausea
3. Vomiting
4. Constipation
5. Blurred vision
6. Urinary hesitancy
7. Urine retention
8. Tachycardia
9. Headache
10. Drowsiness
11. Dizziness
12. Confusion

Contra-indications of Oxyphenonium
1. Hypersensitivity to Oxyphenonium and other anticholinergic drugs
2. Narrow angle glaucoma
3. Obstructive gastro intestinal tract
4. Obstructive uropathy
5. Paralytic ileus
6. Myasthenia gravis
Special Precautions while taking Oxyphenonium
1. Heart failure
2. Hypertension
3. Hyperthyroidism
4. Pyloric stenosis
5. Prostatic hypertrophy
5. Chronic lung disease in debilitated patients
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Oxyphenonium
1. Peptic ulcer
2. Gastritis
3. Renal colic
4. Biliary colic
5. Spasm of gastrointestinal tract

Interactions for Oxyphenonium
Belladona alkaloids, Procainamide, Quinidine, Amantidine, Antihistaminics, Phenothiazines & TCAs: Efficacy of oxyphenonium bromide potentiated leading to excessive, cholinergic blockade.
Other drugs: Absorption of other drugs, given concomitantly, may be delayed.
Typical Dosage for Oxyphenonium
Adult: 20 - 40 mg / day in 4 divided doses
Children: 2.5 -7-5 mg / day in 1 - 3 times daily.
Schedule of Oxyphenonium
N/A
Storage Requirements for Oxyphenonium
Store in a cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Oxyphenonium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Oxyphenonium
Give supportive measures and symptomatic treatment.

Home Delivery for Oxyphenonium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxyphenonium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxyphenonium and other medicines and health products. Home delivery services for oxyphenonium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxyphenonium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxyphenonium before they complete the sale. You can get this information while placing the order for oxyphenonium with the pharmacy.

Oxyphenonium is a generic medicine name and there are several brands available for it. Some of the brands for oxyphenonium might be better known than oxyphenonium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxyphenonium in stock, you can ask for one of the branded alternatives for oxyphenonium.