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- Pharmacology For Alpha-Lipoic acid + Minerals + Multivitamins
Alpha-Lipoic acid + Minerals + Multivitamins Pharmacology
Alpha-Lipoic acid + Minerals + Multivitamins
About Alpha-Lipoic acid + Minerals + MultivitaminsN/AMechanism of Action of Alpha-Lipoic acid + Minerals + MultivitaminsN/APharmacokinets of Alpha-Lipoic acid + Minerals + MultivitaminsN/AOnset of Action for Alpha-Lipoic acid + Minerals + MultivitaminsN/ADuration of Action for Alpha-Lipoic acid + Minerals + MultivitaminsN/AHalf Life of Alpha-Lipoic acid + Minerals + MultivitaminsN/ASide Effects of Alpha-Lipoic acid + Minerals + MultivitaminsN/AContra-indications of Alpha-Lipoic acid + Minerals + MultivitaminsN/ASpecial Precautions while taking Alpha-Lipoic acid + Minerals + MultivitaminsN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid + Minerals + Multivitamins1.Diabetes
2.Oxidative stress
3.Tissue injury
4.Adjuvant in cardiovascular disease management
Interactions for Alpha-Lipoic acid + Minerals + MultivitaminsN/ATypical Dosage for Alpha-Lipoic acid + Minerals + Multivitamins1 capsule / daySchedule of Alpha-Lipoic acid + Minerals + MultivitaminsN/AStorage Requirements for Alpha-Lipoic acid + Minerals + MultivitaminsN/AEffects of Missed Dosage of Alpha-Lipoic acid + Minerals + MultivitaminsN/AEffects of Overdose of Alpha-Lipoic acid + Minerals + MultivitaminsN/AAlpha-Lipoic acid
About Alpha-Lipoic acidNaturally occurring dithiol compound , antioxidant, Agent for neuropathies.Mechanism of Action of Alpha-Lipoic acidAlpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.
Pharmacokinets of Alpha-Lipoic acidAbsorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.
Onset of Action for Alpha-Lipoic acidN/ADuration of Action for Alpha-Lipoic acidN/AHalf Life of Alpha-Lipoic acidN/ASide Effects of Alpha-Lipoic acid1.Nausea
2.VomitingContra-indications of Alpha-Lipoic acid1.Contraindicated during radiotherapySpecial Precautions while taking Alpha-Lipoic acidPatient with diabetes and problems with glucose intolerancePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disordersInteractions for Alpha-Lipoic acidN/ATypical Dosage for Alpha-Lipoic acidAdult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.Schedule of Alpha-Lipoic acidN/AStorage Requirements for Alpha-Lipoic acidStore at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.Effects of Missed Dosage of Alpha-Lipoic acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of Alpha-Lipoic acidGive supportive measures and symptomatic treatment.Minerals
About MineralsDietary mineral supplement, Nutritional supplement.Mechanism of Action of MineralsN/APharmacokinets of MineralsN/AOnset of Action for MineralsN/ADuration of Action for MineralsN/AHalf Life of MineralsN/ASide Effects of MineralsN/AContra-indications of MineralsN/ASpecial Precautions while taking MineralsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for MineralsN/AInteractions for MineralsN/ATypical Dosage for MineralsN/ASchedule of MineralsN/AStorage Requirements for MineralsN/AEffects of Missed Dosage of MineralsN/AEffects of Overdose of MineralsN/AMultivitamins
About MultivitaminsDietary supplement, Vitamins.Mechanism of Action of MultivitaminsN/APharmacokinets of MultivitaminsN/AOnset of Action for MultivitaminsN/ADuration of Action for MultivitaminsN/AHalf Life of MultivitaminsN/ASide Effects of MultivitaminsN/AContra-indications of MultivitaminsN/ASpecial Precautions while taking MultivitaminsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for MultivitaminsN/AInteractions for MultivitaminsN/ATypical Dosage for MultivitaminsN/ASchedule of MultivitaminsN/AStorage Requirements for MultivitaminsN/AEffects of Missed Dosage of MultivitaminsN/AEffects of Overdose of MultivitaminsN/AHome Delivery for Alpha-Lipoic acid + Minerals + Multivitamins in Your City
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