Clidinium Bromide Pharmacology

Clidinium Bromide

About Clidinium Bromide
It is a quaternary ammonium compound with anticholingeric properties, Antispasmodics (Systemic).
Mechanism of Action of Clidinium Bromide
Clidinium bromide is an anticholinergic drug. It exerts its action by inhibiting muscarinic cholinergic receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.
Pharmacokinets of Clidinium Bromide
Absorption: Clidinium bromide is poorly absorbed about (10 - 25 %) after oral administration.
Distribution:It does not penetrate CNS and eye.
Metabolism: It is extensively metabolised in the small intestine (by hydrolysis) and in the liver to inactive metabolites.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Clidinium Bromide
60 minute
Duration of Action for Clidinium Bromide
3 hours
Half Life of Clidinium Bromide
N/A
Side Effects of Clidinium Bromide
1.Dry mouth
2.Nausea
3.Vomiting
4.Constipation
5.Muscle weakness
6.Blurred vision
7.Drowsines
Contra-indications of Clidinium Bromide
1.Hypersensitivity to Clidinium bromide and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Bladder neck obstruction
5.Prostatic hypertrophy
Special Precautions while taking Clidinium Bromide
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular diseases- Hypertension
4.Use caution while performing driving or performing other works requiring mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Clidinium Bromide
1.Peptic ulcer
2.Gastritis
3.Irritable bowel syndrome
4.Nervous dyspepsia
Interactions for Clidinium Bromide
Amantadine : Increase in anticholingeric side effects.
Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced .
Phenothiazines : Decreases antipsychotic activity, and increases anticholingeric activity.
TCAs: Increased anticholinergic side effects ( Dry mouth, constipation, urinary retention)
Typical Dosage for Clidinium Bromide
Adult: 2.5 - 5 mg 3 - 4 times daily before meals and at bed time.
Children: not recommended.
Schedule of Clidinium Bromide
H
Storage Requirements for Clidinium Bromide
Store at below 30 degree C in a tightly closed container. Protect from moisture and sunlight.
Keep out of the reach of children
Effects of Missed Dosage of Clidinium Bromide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clidinium Bromide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Clidinium Bromide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clidinium bromide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clidinium bromide and other medicines and health products. Home delivery services for clidinium bromide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clidinium bromide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clidinium bromide before they complete the sale. You can get this information while placing the order for clidinium bromide with the pharmacy.

Clidinium Bromide is a generic medicine name and there are several brands available for it. Some of the brands for clidinium bromide might be better known than clidinium bromide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clidinium bromide in stock, you can ask for one of the branded alternatives for clidinium bromide.