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- Pharmacology For Iron Sorbitol Citrate acid + Folic acid + Vit B12
Iron Sorbitol Citrate acid + Folic acid + Vit B12 Pharmacology
Iron Sorbitol Citrate acid + Folic acid + Vit B12
About Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AMechanism of Action of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/APharmacokinets of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AOnset of Action for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/ADuration of Action for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AHalf Life of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/ASide Effects of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AContra-indications of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/ASpecial Precautions while taking Iron Sorbitol Citrate acid + Folic acid + Vit B12N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AInteractions for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/ATypical Dosage for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/ASchedule of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AStorage Requirements for Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AEffects of Missed Dosage of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AEffects of Overdose of Iron Sorbitol Citrate acid + Folic acid + Vit B12N/AIron Sorbitol Citrate Acid
About Iron Sorbitol Citrate AcidParenteral iron preparation, Antianemic,hematinic.Mechanism of Action of Iron Sorbitol Citrate AcidIron Sorbitol citric acid is a sterile colloidal solution of a complex of ferric iron, sorbitol, and citric acid.Pharmacokinets of Iron Sorbitol Citrate AcidAbsorption: It is rapidly absorbed from the injection site and is stable in tissue fluids. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. A small fraction of ferritin is excreted in urine.Onset of Action for Iron Sorbitol Citrate AcidN/ADuration of Action for Iron Sorbitol Citrate AcidN/AHalf Life of Iron Sorbitol Citrate AcidN/ASide Effects of Iron Sorbitol Citrate Acid1.Pain, temporary discoloration at the site of injection
2.Transient metallic taste
3.Nausea
4.Vomiting
5.Diarrhea
6.Headache
7.Dizziness
8.Sweating
9.Flushing
10.Hematuria
Contra-indications of Iron Sorbitol Citrate Acid1.Anaemia other than iron deficiency anaemia
2.Acute pyelonephritis
3.Hepatic disease
4.First trimester of pregnancy
5.Hypersensitivity to Iron sorbitol
6.Other than intramuscular use
7.Acute leukaemia
8.Renal impairment
9.Urinary tract infections
Special Precautions while taking Iron Sorbitol Citrate Acid1.Asthma
2.Heart disease
3.Haemoglobinopathies
4.History of allergies
5.Underweight people
Pregnancy Related InformationFirst trimester: Contraindicated
Use with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Iron Sorbitol Citrate Acid1.Iron deficiency
2.Iron deficiency anemiaInteractions for Iron Sorbitol Citrate AcidThe concomitant administration of chloramphenicolTypical Dosage for Iron Sorbitol Citrate AcidIntramuscular injection:
Adults: 1.5 mg iron/kg body weight/ day. Maximum dose: 2 mL of iron sorbitol
Children: Same as adult dose
Schedule of Iron Sorbitol Citrate AcidN/AStorage Requirements for Iron Sorbitol Citrate AcidStore at room temperature.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of Iron Sorbitol Citrate AcidThe doctor should be informed immediately if a dose is missedEffects of Overdose of Iron Sorbitol Citrate AcidTreatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Vit B12
About Vit B12N/AMechanism of Action of Vit B12Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.Pharmacokinets of Vit B12Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12N/ADuration of Action for Vit B12N/AHalf Life of Vit B12N/ASide Effects of Vit B121. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B121. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B121. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Vit B121. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12N/ATypical Dosage for Vit B12I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12CStorage Requirements for Vit B12Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.Effects of Missed Dosage of Vit B12Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B12Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.Home Delivery for Iron Sorbitol Citrate acid + Folic acid + Vit B12 in Your City
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