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- Pharmacology For Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6
Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6 Pharmacology
Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6
About Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AMechanism of Action of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/APharmacokinets of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AOnset of Action for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/ADuration of Action for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AHalf Life of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/ASide Effects of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AContra-indications of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/ASpecial Precautions while taking Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AInteractions for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/ATypical Dosage for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/ASchedule of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AStorage Requirements for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AEffects of Missed Dosage of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AEffects of Overdose of Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6N/AIron lll Hydroxide Polymaltose (IPC)
About Iron lll Hydroxide Polymaltose (IPC)It is a water soluble iron oxide, macro molecular complex of poly nuclear iron (III) hydroxide and partially hydrolysed dextrin (polymaltose).
Mechanism of Action of Iron lll Hydroxide Polymaltose (IPC)The absorption of ferric iron from IPC is controlled by a feedback mechanism. When IPC comes in contact with the iron binding sides at the mucosal surface, a physiological exchange is assumed to occur. IPC releases the required amount of ferric iron, which is actively transported into the mucosal cell by a carrier protein and from there released for binding to ferritin or transferrin.Pharmacokinets of Iron lll Hydroxide Polymaltose (IPC)N/AOnset of Action for Iron lll Hydroxide Polymaltose (IPC)N/ADuration of Action for Iron lll Hydroxide Polymaltose (IPC)N/AHalf Life of Iron lll Hydroxide Polymaltose (IPC)N/ASide Effects of Iron lll Hydroxide Polymaltose (IPC)There is a very low incidence of adverse effects. Occasionally gastrointestinal symptoms such as sensation of repletion, pressure in the epigastric reagion, nausea, constipation or diarrhoea can occur.Contra-indications of Iron lll Hydroxide Polymaltose (IPC)N/ASpecial Precautions while taking Iron lll Hydroxide Polymaltose (IPC)N/APregnancy Related InformationMay be used.Old Age Related InformationMay be used.Breast Feeding Related InformationMay be used.Children Related InformationN/AIndications for Iron lll Hydroxide Polymaltose (IPC)Treatment of latent iron deficiency and iron deficiency anaemia. Prevention of iron and folic acid deficiency before, during and after pregnancy. For prophylatic therapy of iron deficiency to cover the recommended daily dietary allowence during pregnancy and lactation.
Interactions for Iron lll Hydroxide Polymaltose (IPC)N/ATypical Dosage for Iron lll Hydroxide Polymaltose (IPC)Dosage and duration of therapy are dependent upon the extent of iron deficiency. It should be taken during or immediately after meals.Schedule of Iron lll Hydroxide Polymaltose (IPC)N/AStorage Requirements for Iron lll Hydroxide Polymaltose (IPC)Store at room temperature.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of Iron lll Hydroxide Polymaltose (IPC)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron lll Hydroxide Polymaltose (IPC)Relatively non toxic. Provide symptomatic treatment and supportive measures.Vit B12
About Vit B12N/AMechanism of Action of Vit B12Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.Pharmacokinets of Vit B12Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12N/ADuration of Action for Vit B12N/AHalf Life of Vit B12N/ASide Effects of Vit B121. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B121. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B121. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Vit B121. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12N/ATypical Dosage for Vit B12I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12CStorage Requirements for Vit B12Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.Effects of Missed Dosage of Vit B12Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B12Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.Vit B6
About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.Home Delivery for Iron lll Hydroxide Polymaltose (IPC) + Vit B12 + Vit B6 in Your City
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