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Iron (Liver extract) + Vit B3 + Vit B1 Pharmacology
Iron (Liver extract) + Vit B3 + Vit B1
About Iron (Liver extract) + Vit B3 + Vit B1N/AMechanism of Action of Iron (Liver extract) + Vit B3 + Vit B1N/APharmacokinets of Iron (Liver extract) + Vit B3 + Vit B1N/AOnset of Action for Iron (Liver extract) + Vit B3 + Vit B1N/ADuration of Action for Iron (Liver extract) + Vit B3 + Vit B1N/AHalf Life of Iron (Liver extract) + Vit B3 + Vit B1N/ASide Effects of Iron (Liver extract) + Vit B3 + Vit B1N/AContra-indications of Iron (Liver extract) + Vit B3 + Vit B1N/ASpecial Precautions while taking Iron (Liver extract) + Vit B3 + Vit B1N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Liver extract) + Vit B3 + Vit B1N/AInteractions for Iron (Liver extract) + Vit B3 + Vit B1N/ATypical Dosage for Iron (Liver extract) + Vit B3 + Vit B1N/ASchedule of Iron (Liver extract) + Vit B3 + Vit B1N/AStorage Requirements for Iron (Liver extract) + Vit B3 + Vit B1N/AEffects of Missed Dosage of Iron (Liver extract) + Vit B3 + Vit B1N/AEffects of Overdose of Iron (Liver extract) + Vit B3 + Vit B1N/AIron (Liver extract)
About Iron (Liver extract)Oral iron preparation, Antianemic,hematinic.Mechanism of Action of Iron (Liver extract)Liver extract and desiccated (dried) liver are given as iron supplements. Iron formulations exert haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.Pharmacokinets of Iron (Liver extract)Absorption:It is completely absorbed after parenteral administration.Onset of Action for Iron (Liver extract)N/ADuration of Action for Iron (Liver extract)N/AHalf Life of Iron (Liver extract)N/ASide Effects of Iron (Liver extract)1. Nausea
2. Epigasttric distress
3. Vomiting
4. Constipation
5. Diarrhoea
6. Black stools
7. Temporary staining of teeth with liquid formulationsContra-indications of Iron (Liver extract)1. Haemolytic anaemia
2. Haemochromatosis
3. Haemosiderosis
4. Peptic ulcer
5. Regional enteritis
6. Ulcerative colitis
7. Those receiving repeated blood transfusionsSpecial Precautions while taking Iron (Liver extract)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occursPregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Liver extract)1.Severe Nutritional anaemia
2.Macrocytic anaemia
3.Megaloblastic anaemia
4.Hepatitis
5.Liver cirrhosis
Interactions for Iron (Liver extract)N/ATypical Dosage for Iron (Liver extract)As directed by the PhysicianSchedule of Iron (Liver extract)N/AStorage Requirements for Iron (Liver extract)N/AEffects of Missed Dosage of Iron (Liver extract)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Liver extract)Give supportive measures and symptomatic treatment.Vit B3
About Vit B3N/AMechanism of Action of Vit B3Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and it`s phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of Vit B3Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for Vit B3N/ADuration of Action for Vit B3N/AHalf Life of Vit B3N/ASide Effects of Vit B31. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Vit B31. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Vit B31.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of StatinsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Vit B31. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)Interactions for Vit B3Aspirin: May decrease the metabolic clearance of nicotinic acid
Sympathetic blocking agent: May cause added vasodilation and hypotension
Isoniazid: may deplete levels of niacin and cause deficiency.
Typical Dosage for Vit B3Oral:
Pellagra: 200 to 500mg daily in divided doses
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Peripheral vascular diseases (only nicotinic acid): 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia (only nicotinic acid): 1.5 to 6g daily in two to four divided doses with or after meals.
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Vit B3C1Storage Requirements for Vit B3Store at controlled room temperature at a range of 15 to 30 degree CEffects of Missed Dosage of Vit B3Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B3Provide supportive measures and symptomatic treatmentVit B1
About Vit B1
Physiological functions: Thiamine pyrophosphate is a coenzyme and the active form of vitamin B. It functions as coenzyme in decarboxylation of a-keto acid and in Hexose Monophosphate shunt.
Deficiency symptoms: In severe vitamin B1 deficiency beriberi develops. It is of two types:
a) Wet beriberi
b) Dry beriberi
Wet beriberi: In this the symptoms are related to the cardiovascular system and they are palpitations, tachycardia, dyspnoea, ECG changes, oedema, and high output cardiac failure.
Dry beriberi: The symptoms and signs are related to the Nervous system. The main features are peripheral neuritis, hyperaesthesia (localized areas) or anaesthesia, there is gradual loss in muscle strength, wrist drop, poor memory, depression, lack of initiative and anorexia.Mechanism of Action of Vit B1Thiamine exerts it`s action by influencing carbohydrate metabolism. It combines with ATP to form thiamine pyrophosphate in the body. Thiamine pyrophosphate acts as a coenzyme for carbohydrate metabolism, decarboxylation of ketoacids, and hexose monophosphate shunt. It also have plays some role in neuromuscular transmission.Pharmacokinets of Vit B1Absorption: Well absorbed orally.
Distribution: Widely distributed in the body. It is also distributed in to breast milk.
Metabolism: Metabolized in the liver.
Excretion: Excess thiamine is excreted through urine.
Onset of Action for Vit B1N/ADuration of Action for Vit B1N/AHalf Life of Vit B1N/ASide Effects of Vit B11. Angioedema
2. Cardiovascular collapse
3. Cyanosis
4. Restleessness
5. Nausea
6. Haemorrhage
7. Weakness
8. Allergic reactions
9. Tightness of throat
10. Feeling of warmth
11. Urticaria
12. Pruritus
13. Tenderness and induration following I. M. administration
Contra-indications of Vit B11. Hypersensitivity to the drugSpecial Precautions while taking Vit B1N/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vit B11. Thiamine deficiency
2. Dry beriberi
3. Wet beriberi
4. Wernicke`s encephalopathy
5. Hyperemesis gravidarum
6. Korsakoffs syndrome
7. Polyneuritis secondary to alcoholism
8. Multiple neurosis
9. Toxic and confusional states
10. Anorexia nervosa
11. Delirium
Interactions for Vit B1N/ATypical Dosage for Vit B1Oral :
In mild deficiency: 10 to 25mg/day.
In severe deficiency: 200 to 300mg/day.
I.M, I.V.:
Beriberi:
Adults: 10 to 20mg I.M. depending up on the severity of the condition (Up to 100mg I.M. or I.V. for severe cases); thrice daily for two weeks followed by dietary correction and multivitamin supplement containing 5 to 30mg Thiamine/day in single or divided doses for 1 month.
Wernicke`s encephalopathy: 100mg I.V. followed by 50 to 100mg IM. or I.V./day.
"Wet beriberi with heart failure": 10 to 30mg I.V. for emergency treatment.
Schedule of Vit B1C1 (Oral)Storage Requirements for Vit B1Store in a well closed container; in a cool place and protect from light.Effects of Missed Dosage of Vit B1Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B1Provide symptomatic treatment and supportive measures.Home Delivery for Iron (Liver extract) + Vit B3 + Vit B1 in Your City
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