Ergotamine Pharmacology

Ergotamine

About Ergotamine
Ergot alkaloid, Alpha-adrenergic agonist, Anti migraine.
Mechanism of Action of Ergotamine
Ergotamine produces its therapeutic effects by constricting the dilated cranial vessel. Ergotamine reduces shunting of blood flow from carotid artery by specific constriction of the AV shunt channel and is useful in the treatment of migraine. Ergotamine is used in migraine unresponsive to non-opioid analgesics.
Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels. It produces serotonin antagonistic activity and depresses the vasomotor centre.
Pharmacokinets of Ergotamine
Absorption: Ergotamine is well absorbed after inhalation and rapidly and incompletely after oral administration. Its bioavailability is very low since it undergoes extensive first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: Drug and its metabolites are excreted primarily in bile and very small amount in urine also.
Onset of Action for Ergotamine
With in 30 minutes
Duration of Action for Ergotamine
36 hours
Half Life of Ergotamine
2.7 hours & 21 hours
Side Effects of Ergotamine
1.Nausea
2.Vomiting
3.Abdominal discomfort
4.Tingling in fingers and toes
5.Pre-cordial distress and pain
6.Muscle pain
7.Pruritis
Contra-indications of Ergotamine
1.Hypersensitivity to Ergotamine
2.Coronary vascular disease
3.Hypertension
4.Peripheral and occlusive vascular diseases
5.Sepsis
6.Renal impairment
7.Hepatic impairment
8.Ischemic heart diseases
Special Precautions while taking Ergotamine
1.Avoid alcohol and smoking
2.Drug should be discontinued at once after the occurrence of tingling in the fingers or toes
Pregnancy Related Information
Contraidicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated.
NEONATES: contraindicated
Indications for Ergotamine
1. Prevention of vascular headache, migraine and cluster headache
Interactions for Ergotamine
Beta-Blockers, Methysergide & Smoking: Increased risk of vascular occlusion due to peripheral ischaemia.
Oral Contraceptives: Risk of thrombosis increased.
Marcrolides: Acute ergotism manifested as peripheral ischaemia.
Vasodilators: Dangerous hypertension may occur.
Sympathomimetic Agents like Adrenaline: Enhance vasoconstrictor effects.
Typical Dosage for Ergotamine
Adult:
Oral/sublingual: Initial dose: 2 mg repeat 1 - 2 mg every 30 minutes if needed.
Maximum daily dose: 6 mg / day
Maximum weekly dose: 10 mg / week
Inhalations: Initial dose: 1inhalations repeat the same dose after 5 minutes if necessary.
Maximum dose: 6 inhalations / day or 15 inhalations / week.
Suppositories: Initial dose: 2 mg per rectum repeat after 60 minutes if needed.
Maximum dose: 2 suppositories /day or 5 suppositories/ week.
Schedule of Ergotamine
H
Storage Requirements for Ergotamine
Store at 25 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Ergotamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ergotamine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing vomiting. Absorption of the drug can be reduced by administration of activated charcoal. Convulsions can be treated by parenteral Diazepam administration. Dialysis can be done if necessary.

Home Delivery for Ergotamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ergotamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ergotamine and other medicines and health products. Home delivery services for ergotamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ergotamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ergotamine before they complete the sale. You can get this information while placing the order for ergotamine with the pharmacy.

Ergotamine is a generic medicine name and there are several brands available for it. Some of the brands for ergotamine might be better known than ergotamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ergotamine in stock, you can ask for one of the branded alternatives for ergotamine.