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- Pharmacology For Iron (Ferrous sulphate) + Folic acid
Iron (Ferrous sulphate) + Folic acid Pharmacology
Iron (Ferrous sulphate) + Folic acid
About Iron (Ferrous sulphate) + Folic acidN/AMechanism of Action of Iron (Ferrous sulphate) + Folic acidN/APharmacokinets of Iron (Ferrous sulphate) + Folic acidN/AOnset of Action for Iron (Ferrous sulphate) + Folic acidN/ADuration of Action for Iron (Ferrous sulphate) + Folic acidN/AHalf Life of Iron (Ferrous sulphate) + Folic acidN/ASide Effects of Iron (Ferrous sulphate) + Folic acidN/AContra-indications of Iron (Ferrous sulphate) + Folic acidN/ASpecial Precautions while taking Iron (Ferrous sulphate) + Folic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Ferrous sulphate) + Folic acidN/AInteractions for Iron (Ferrous sulphate) + Folic acidN/ATypical Dosage for Iron (Ferrous sulphate) + Folic acidN/ASchedule of Iron (Ferrous sulphate) + Folic acidN/AStorage Requirements for Iron (Ferrous sulphate) + Folic acidN/AEffects of Missed Dosage of Iron (Ferrous sulphate) + Folic acidN/AEffects of Overdose of Iron (Ferrous sulphate) + Folic acidN/AIron (Ferrous sulphate)
About Iron (Ferrous sulphate)Oral iron preparation, Antianemic,hematinic.Mechanism of Action of Iron (Ferrous sulphate)Ferrous sulfate is used as a source of iron for iron-deficiency anaemia. It is given by mouth; the dried form is often used in solid dosage forms and the heptahydrate in liquid dosage forms. Usual doses of dried ferrous sulfate are up to 600 mg daily (equivalent to 180 to 195 mg of iron daily,).
Ferrous sulfate oxidised with nitric and sulfuric acids yields ferric subsulfate solution, also known as Monsel`s solution, which has been used as a haemostatic. It exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
Pharmacokinets of Iron (Ferrous sulphate)Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.Onset of Action for Iron (Ferrous sulphate)N/ADuration of Action for Iron (Ferrous sulphate)N/AHalf Life of Iron (Ferrous sulphate)N/ASide Effects of Iron (Ferrous sulphate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations.
Contra-indications of Iron (Ferrous sulphate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Ferrous sulphate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Ferrous sulphate)1. Iron deficiency
2. Iron deficiency anaemiaInteractions for Iron (Ferrous sulphate)N/ATypical Dosage for Iron (Ferrous sulphate)Adults: 100 to 300mg; twice daily. Increases the dosage based on patient`s response if required up to 300mg 4 times daily.
Children (age 2 to 12): 3mg/kg/day in three to four divided doses
Children (age 6months to 2years): 3 to 6mg/kg/day in three to four divided doses
Infants: 10 to 25mg/day in three to four divided doses.
Schedule of Iron (Ferrous sulphate)HStorage Requirements for Iron (Ferrous sulphate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Ferrous sulphate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Ferrous sulphate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl. Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Home Delivery for Iron (Ferrous sulphate) + Folic acid in Your City
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